Application of Hydrogels as Three-Dimensional Bioprinting Ink for Tissue Engineering

Xie, Mengbo; Su, Juanjuan; Zhou, Shengxi; Li, Jingan; Zhang, Kun

doi:10.3390/gels9020088

Cited by 17 publications

(12 citation statements)

References 133 publications

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“…154 3D bioprinting is a rapidly developing technology that simulates the microenvironment of natural tissues by printing specific patterned structures with bioinks containing biological materials, drugs, and cytokines. 155 Recently, 3D bioprinted scaffolds that promote wound healing are increasingly used in skin tissue engineering. 156 For example, 3D bioprinted scaffolds loaded with VEGF could significantly inhibit the inflammatory response and promote the formation of new blood vessels, thus achieving rapid wound healing.…”

Section: Cell-free Scaffoldmentioning

confidence: 99%

New insights into balancing wound healing and scarless skin repair

Zhou

Xie

et al. 2023

J Tissue Eng

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Scars caused by skin injuries after burns, wounds, abrasions and operations have serious physical and psychological effects on patients. In recent years, the research of scar free wound repair has been greatly expanded. However, understanding the complex mechanisms of wound healing, in which various cells, cytokines and mechanical force interact, is critical to developing a treatment that can achieve scarless wound healing. Therefore, this paper reviews the types of wounds, the mechanism of scar formation in the healing process, and the current research progress on the dual consideration of wound healing and scar prevention, and some strategies for the treatment of scar free wound repair.

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Section: Cell-free Scaffoldmentioning

confidence: 99%

New insights into balancing wound healing and scarless skin repair

Zhou

Xie

et al. 2023

J Tissue Eng

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“…16,17 The incorporation of nanoparticles into polymer hydrogel presents an opportunity to address the existing limitations of conventional bioinks. 18 The mechanical and structural properties of pure polymeric hydrogels can be enhanced by including reinforcement, thereby enabling them to closely mimic native cellular microenvironments. This synergistic approach allows for the utilization of these improved properties in a wide range of tissue engineering applications that are clinically relevant.…”

Section: Introductionmentioning

confidence: 99%

“…26 In addition to this, the utilization of composite alginate has the potential for medical and food technology. 18,27 This paper examines in depth the production of alginate composites, 3D printing techniques for alginate composites, and applications of 3D printing alginate composites.…”

Section: Introductionmentioning

confidence: 99%

Review of alginate-based composites for 3D printing material

Bukit,

Syamani,

Rochima

et al. 2024

Polymers from Renewable Resources

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The ability of alginates to form hydrogel solutions makes them a promising biomaterial for three-dimensional (3D) printing. Researchers are investigating several techniques to improve the alginate hydrogels’ quality, such as using alginate-based nanocomposites as materials for 3D printing. This review examines the material of alginate-based composites, the printing technique, and the applications of 3D printing alginate-based composites. Material composites for 3D printing include alginate with clay, a combination of alginate with polymers or biopolymers, and a mixture of alginate with metal oxide and carbon. The 3D printing material from alginate combined with polymers is usually used in the medical and green packaging industries, whereas a mixture of alginate with clay, metal oxide, and carbon 3D printing material is utilized in the environmental field. When considering printing procedures, extrusion techniques are the most affordable. Furthermore, the purpose of alginate composite characterization is to determine the impact generated by the material combinations. This characterization is carried out based on the intended application. However, it is common to employ mechanical, thermal, rheological, scanning electron, XRD, and FTIR analysis to identify the fundamental characteristics of the alginate composite according to research.

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“…Additionally, they have a common use in extrusion-based AM due to their rheological behavior. However, there are two drawbacks that frequently occur when printing hydrogels: the challenge of modifying the printing behavior and the constrained mechanical properties of the printed scaffolds [12].…”

Section: Introductionmentioning

confidence: 99%

Direct Ink Writing of Alginate–Gelatin Hydrogel: An Optimization of Ink Property Design and Printing Process Efficacy

2023

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Direct Ink Writing (DIW), which is widely used for developing functional 3D scaffolds that have robust structural integrity for the growth of target tissues/cells, has emerged as an appealing method for biomedical applications. The production of 3D structures involves three separate but interconnected stages (material development, printing process, and post-printing treatment), whose effectiveness is influenced by several factors that therefore make it challenging to optimize the entire procedure. By studying the material processability and leveling the printing settings, this study proposes a three-step method to enhance the ink property design and the printer’s performance. The recommended approach is focused on the thorough study of alginate–gelatin hydrogel properties, which is a commonly used ink in biomedical applications, due to its natural origin through marine flora, as well as the development process parameters and their intercorrelations. Principal Component Analysis in comparison with K-means clustering was applied to reveal material properties that are highly correlated with additive manufacturing (AM) processability, and Taguchi’s Design of Experiments (DOE) determined the printing settings (primary and secondary) for achieving optimum printing accuracy. PCA results were affirmed by K-means clustering and showed that viscosity, m, G′ and G″ govern blends’ printing behavior while application of DOE led to 85% pore area printability.

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Application of Hydrogels as Three-Dimensional Bioprinting Ink for Tissue Engineering

Cited by 17 publications

References 133 publications

New insights into balancing wound healing and scarless skin repair

New insights into balancing wound healing and scarless skin repair

Review of alginate-based composites for 3D printing material

Direct Ink Writing of Alginate–Gelatin Hydrogel: An Optimization of Ink Property Design and Printing Process Efficacy

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