Application of Human Leucocyte Interferon in Patients With Carcinoma of the Uterine Cervix

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

“…In future, this therapy may become relevant in the management of oral cancers with N0 neck. These biological response modifiers occur naturally in the body but they can also be produced in the laboratory [72,78]. These agents include interferons, interleukins, colony-stimulating factors, monoclonal antibodies, vaccines, gene therapy and nonspecific immune-modulating agents.…”

“…These agents include interferons, interleukins, colony-stimulating factors, monoclonal antibodies, vaccines, gene therapy and nonspecific immune-modulating agents. Their exact mechanism of action is not fully known but they are thought to boost the power of the immune system to destroy or kill cancer cells such as T cells, NK cells and macrophages, make cancer cells more recognizable by the immune system, stop the process which changes normal cells to cancer cells, enhance the body system to repair or replace damaged normal cells and also keep the cancer cells from spreading to other parts of the body [72,78,89].…”

Interferons in the treatment of human papillomavirus diseases

“…The use of interferon for HPV-related diseases was actually begun before DNA hybridization studies confirmed virus involvement, Clinical investigations of crude human leukocyte interferon (HLI) were conducted at the Institute of Immunology in Zagreb, Yugoslavia, in the 1970's (28)(29)(30)(31)(32). Early clinical trials involved the treatment of some malignant tumors, including invasive squamous cell carcinoma and precancerous states of the uterine cervix.…”

“…No pathologic progression was detected during the two year period of observation. In contrast, the lesions of control patients demonstrated malignant progression (30,31), Cancer studies were organized into three phases. In Phase I, intralesional injections were administered to 10 patients with cervical cancer and changes were monitored cytologically and histologically (32).…”

“…Histological and histochemical findings in the tumors and the regional lymph nodes indicated improvement. In the third phase, 15 patients with invasive squamous cell carcinoma of the uterine cervix were treated with interferon prior to surgical removal of the tumor (30). In three patients, the 149 surgical material was free of tumor cells, and in one patient a lower grade of carcinoma was observed.…”