Interferons in the treatment of human papillomavirus diseases

Weck, Phillip K.; Brandsma, Janet L.; Whisnant, John K.

doi:10.1007/bf00046428

Cited by 25 publications

(16 citation statements)

References 64 publications

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“…The synthesis of 14 and related derivatives has recently been reviewed (62). Studies have-shown that DHPG, 10, is very effective in the treatment of herpetic corneal lesions in rabbits (63).…”

Section: Bmentioning

confidence: 99%

“…They are divided in established indications which are beyond doubt, and possible indications, for which the clinical significance remains to be proven. The viral infection in which interferon has led to the most dramatic response, is juvenile laryngeal papillomatosis (JLP) (63). It is a wartlike disease which occurs commonly around the vocal cords and leads to considerable morbidity and mortality, especially when the disease starts early in life.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Also condylomata acuminata (63) or genital warts are associated with human papillomavirus types 6 and 11. For this disease, as for JLP, there was no consistent therapy before interferon was proven to be effective.…”

Section: Clinical Studiesmentioning

confidence: 99%

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Antiviral Drug Development

Clercq¹,

Walker²

1988

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All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher ACKNOWLEDGEMENTS This Advanced Study Institute was sponsored by NATO (ASI no 237/86) and co-sponsored by FEBS (Advanced Course no 87/02). The Course Directors also acknowledge the financial assistance of the following companies :

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Section: Bmentioning

confidence: 99%

Section: Clinical Studiesmentioning

confidence: 99%

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Antiviral Drug Development

Clercq¹,

Walker²

1988

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“…After encountering promising results with interferon-~ therapy in a concomitant trial [5], we monitored its proficiency and conducted this comparative trial. Interferons are a group of lowmolecular weight (24-26 kDa) glycoproteins which act on cells to interfere with viral replication, thereby inhibiting the production of various RNA, DNA viruses including human papilloma viruses [6].…”

Section: Introductionmentioning

confidence: 99%

Management of genital warts in women with human leukocyte interferon-? vs. podophyllotoxin in cream: a placebo-controlled, double-blind, comparative study

Syed

Khayyami²,

Kříž³

et al. 1995

J Mol Med

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The purpose of this double-blind, placebo-controlled, comparative study was to evaluate the specific clinical efficacy and tolerance of human leukocyte interferon-alpha (2 x 10(6) IU/g) and podophyllotoxin 0.5% incorporated in a hydrophilic cream to cure genital warts. Preselected Asian women (n = 60) aged 18-40 years (mean 22.9), with a clinical and biopsy-confirmed diagnosis of genital warts, harboring 322 lesions (mean 5.36) were randomly assigned to three parallel groups to receive one of the two test drugs or placebo. Each patient received a precoded tube (40 g) containing either human leukocyte interferon-alpha, podophyllotoxin, or identically appearing placebo cream for 3 days' usage. In addition to written instructions, each subject was shown how to apply a minimal amount of trial medication on their lesions thrice daily for 3 consecutive days per week (maximum nine topical applications per week). Patients were examined on a weekly basis, and a cure was considered to be a biopsy-confirmed, total elimination of a lesion. Moreover, patients cured during the study period were spared further therapy, and were requested to return in 16 weeks to monitor for the occurrence of a relapse. The remaining patients' empty tubes were collected, and similarly precoded replacement tubes were given to continue the treatment; a total of 214 tubes were used. The study was scheduled for 16 weeks with 4 weeks of active treatment. Individuals were excluded from the study due to pregnancy, breast feeding, or the receiving of any type of antiviral therapy during the 4 weeks preceding enrollment.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…It is also known to be associated with human Papillo mavirus (HPV) in approximately 90% of cases. IFNs have been demonstrated to induce regression of warts associat ed with HPV and to effectively treat other Papillomavi rus-related diseases such as respiratory papillomatosis [77] suggesting a strong rationale for their use in CIN.…”

Section: Cervical Cancer and Cervical Intraepithelial Neoplasiamentioning

confidence: 99%

Interferons in the Therapy of Solid Tumors

Agarwala

Kirkwood

1994

Oncology

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Interferons, a group of naturally occurring proteins, possess potent immunological effects. The availability of large amounts of purified interferon through recombinant DNA technology has led to the testing of these agents against a number of tumor types. Interferon-α has been the most widely studied. The most encouraging results have been observed in the treatment of melanoma among nonhematological neoplasms, and in the locoregional treatment of other tumor types. It is hoped that further research into the use of the interferons, both singly and in combination with chemotherapy and other immunological agents, will lead to a better elucidation of their therapeutic role against cancer. In this article, the use of interferons in the treatment of solid tumors is reviewed.

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Interferons in the treatment of human papillomavirus diseases

Cited by 25 publications

References 64 publications

Antiviral Drug Development

Antiviral Drug Development

Management of genital warts in women with human leukocyte interferon-? vs. podophyllotoxin in cream: a placebo-controlled, double-blind, comparative study

Interferons in the Therapy of Solid Tumors

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