Application of hair analysis to document illegal 5-methoxy-N,N-dissopropyltrptamine (5-MeO-DiPT) use

Wang, Roujia; Xiang, Ping; Yu, Zhiguo; Shi, Yan

doi:10.1016/j.forsciint.2019.109972

Cited by 11 publications

(17 citation statements)

References 23 publications

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“…Generally, the analytical methodology consisted of the following steps: hair decontamination from external contaminants, hair digestion or pulverization and analytes extraction from a hair amount ranging between 10−100 mg. The hair decontamination procedures used were washing with: (i) organic solvents, such as methanol [ 20 , 21 , 23 , 24 , 32 , 34 , 43 , 44 , 47 , 50 , 51 , 53 , 54 , 56 , 58 , 60 ], ethanol [ 35 ], acetone [ 19 , 22 , [25] , [26] , [27] , 37 , 38 , 41 , 46 , 49 , 57 , 61 , 63 ], hexane [ 27 ], petroleum ether [ 41 , 49 ], dichloromethane [ 20 , 21 , 23 , 24 , [28] , [29] , [30] , [31] , 33 , 34 , 36 , 39 , 40 , 42 , 45 , 48 , [52] , [53] , [54] , [55] , [56] , [58] , [59] , [60] , 62 ], isopropanol [ 23 , 28 ], isooctane [ 38 , 52 ]; (ii) sodium dodecyl sulfate solution [ 35 , …”

Section: Extraction and Detection Methods For The Determination Of Nps In Hairmentioning

confidence: 99%

Hair analysis for New Psychoactive Substances (NPS): Still far from becoming the tool to study NPS spread in the community?

Florou

Boumba

2021

Toxicology Reports

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Section: Extraction and Detection Methods For The Determination Of Nps In Hairmentioning

confidence: 99%

Hair analysis for New Psychoactive Substances (NPS): Still far from becoming the tool to study NPS spread in the community?

Florou

Boumba

2021

Toxicology Reports

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“…In another study, the hair of the victims in DFC cases was cut into smaller segments of 0.5 cm to study the distri bution of clonazepam and to infer the drug inges tion time (Figure 3) [41]. In one recent study [42] on the kinetics of antipsychotic drugs in hair, hair segments were cut into 3 mm lengths, which helped to find the hair segments with peak concentration and infer the ingestion time. Kintz [43] suggested that the drug intake pattern should be inferred according to the drug concentration in 2cm hair segments corresponding to the time of the crime and the adjacent hair segments assuming a hair growth rate of approximately 1 cm/month.…”

Section: Drug-facilitated Crime Casesmentioning

confidence: 99%

Current status of hair analysis in forensic toxicology in China

Yan

Xiang

Shen

2021

Forensic Sciences Research

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Hair analysis has been mainly used to document drug use history in abusers, drug-facilitated crime cases, doping control analysis and postmortem toxicology in the fields of forensic toxicology, clinical toxicology, and doping control. Hair analysis has also gained more attention in the last 30 years in China. Relevant technology has been promoted as more research has appeared concerning hair analysis, and consensus has been sought among forensic toxicologists regarding aspects such as hair decontamination treatment, detection of abused substances in hair, segmental hair analysis and interpretation of analytical results. However, there are still some limitations in the estimation of drug intake time and frequency by segmental hair analysis due to the different growth cycles evident within a bundle of hairs, the drug incorporation mechanism and sampling errors. Microsampling and imaging mass spectrometry (iMS) technology based on a single hair may be a good choice to estimate drug intake time more accurately. Analysis of hair root samples may also be used to document acute poisoning in postmortem toxicology, and the analysis of the hair shaft can document long-term use of drugs depending on the length of the hair being evaluated. Current application of hair analysis in China Confirmation of drug intake and investigation of drug use historyCompared with biological samples such as blood and urine, hair analysis has the advantages of stable presence of exogenous drugs, extended detection window, and the ability to reflect longterm drug abuse history. In 1999, meperidine was detected in

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“…There were several methods described in the literature utilizing an ultrasonic bath to extract the drugs out of the hair. Most procedures involved hair pulverization followed by ultrasonication for several hours to extract the drugs from the hair [17,[20][21][22][23]. In the present study, hair pulverization and solvent extraction were combined together with high-speed grinding using a high-efficiency hair grinder, followed by a 15 min SPME desorption procedure.…”

Section: Optimization Of Hair Grinding Conditionsmentioning

confidence: 99%

“…In the present study, hair pulverization and solvent extraction were combined together with high-speed grinding using a high-efficiency hair grinder, followed by a 15 min SPME desorption procedure. This procedure is more convenient and time-saving when compared with the previous method [17,[20][21][22][23].…”

Section: Optimization Of Hair Grinding Conditionsmentioning

confidence: 99%

“…Nevertheless, traditional hair pre-treatment methods (acid or alkali hydrolysis) are complicated, time-consuming and often associated with low analyte recovery and cross-contamination [13,[18][19][20]. On the contrary, the high-speed grinding could completely break up the hair cuticles, which facilitates the release of drugs and their metabolites in the medulla of hair for liquid chromatographymass spectrometry (LC-MS/MS) analysis [17,[21][22][23][24]. However, due to the low concentration of drugs and their metabolites in hair and the presence of interferent (endogenous substances), false positive or false negative results are difficult to avoid [25,26].…”

Section: Introductionmentioning

confidence: 99%

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Determination of amphetamines, ketamine and their metabolites in hair with high-speed grinding and solid-phase microextraction followed by LC-MS

Meng

Dai²,

Chen

et al. 2020

Forensic Sciences Research

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A novel hair sample pre-treatment method based on high-speed grinding and solid-phase microextraction (SPME) had been applied for the determination of amphetamines, ketamine and their metabolites in hair samples by liquid chromatography-mass spectrometry (LC-MS). A 20 mg sample of hair was ground with 2 mL of saturated sodium carbonate solution using a high-efficiency hair grinder with 70 Hz oscillation for 2 min at 4 °C. After centrifuging, 1.5 mL of the supernatant was transferred and treated with SPME by direct immersion (DI-SPME). The target analytes extracted by fibre were desorbed and analysed using LC-MS. Under the optimum conditions, a recovery of 90.2%–95.8% was obtained for all analytes. The analytical method was linear for all analytes in the range from 0.2 to 10 ng/mg with the correlation coefficient ranging from 0.9985 to 0.9993. The detection limits for all analytes were estimated to be 0.067 ng/mg. The accuracy (mean relative error) was within ±6.9% and the precision (relative standard error) was less than 6.8%. The combination of high-speed grinding of hair and SPME had the advantages of being easy to perform, environment-friendly and high in detection sensitivity. The proposed method offered an alternative analytical approach for the sensitive detection of drugs in hair samples for forensic purposes. Key Points The SPME was involved for the determination of drugs in hair with LC-MS. The hair high-speed grinding combined with SPME was firstly developed. Good linearity, sensitivity, recovery and precision were achieved.

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Application of hair analysis to document illegal 5-methoxy-N,N-dissopropyltrptamine (5-MeO-DiPT) use

Cited by 11 publications

References 23 publications

Hair analysis for New Psychoactive Substances (NPS): Still far from becoming the tool to study NPS spread in the community?

Hair analysis for New Psychoactive Substances (NPS): Still far from becoming the tool to study NPS spread in the community?

Current status of hair analysis in forensic toxicology in China

Determination of amphetamines, ketamine and their metabolites in hair with high-speed grinding and solid-phase microextraction followed by LC-MS

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