Application of Fe(III)-exchanged clinoptilolite/graphite nanocomposite for electrochemical sensing of amitriptyline

Madej, Maria; Fendrych, Katarzyna; Porada, Radosław; Flacha, Mateusz; Kochana, Jolanta; Baś, Bogusław

doi:10.1016/j.microc.2020.105648

Cited by 19 publications

(8 citation statements)

References 46 publications

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“…Previous studies on AMT electrooxidation suggested electrode reaction proceeds via oxidation of tertiary amine group at the end of AMT's carbon chain, through a process in which it creates an aminium radical cation [20b,36] . However, previously developed electrodes that suggested such oxidation process had the similar issues in that they could not differentiate between TCAs as almost all of those compounds have the same amine group on their carbon chain.…”

Section: Resultsmentioning

confidence: 99%

Highly Sensitive and Selective Detection of the Antidepressant Amitriptyline Using a Functionalised Graphene‐Based Sensor

2022

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The accurate measurement of drug concentration in patient samples is vital and is often conducted using point of care devices for therapeutic drug monitoring and other clinical activities. Two dimensional (2D) nanomaterials provide an opportunity to develop miniaturized, affordable and accurate drug sensors, with the promise of developing point of care tests, which are more convenient compared to current techniques that often require advanced instrumentation and laboratory tests. Here we present a reduced graphene oxidebased electrochemical sensor that permits precise measurements of amitriptyline, a well-known anti-depressant. The sensor uses functionalised graphene where amitriptyline selective receptors directly attached to the carbon atoms on the surface of the graphene through diels-alder reaction. The simplicity of the functionalisation procedure along with a tunable receptor used in this study implies that the same method can be used for developing similar selective sensors, simply by changing the small functional groups attached to the receptor molecule. The electrochemical characteristics of the functionalised graphene were studied with cyclic voltammetry, where the sensor demonstrated excellent selectivity, responding only to amitriptyline when tested against closely related tricyclic antidepressants and a range of other psychoactive drugs. The sensor displayed a wider linear range from 1 ng/mL to 80 μg/mL, which covers the concentration range for amitriptyline studied in therapeutic, pharmaceutical, and forensic investigations. The limit of detection of the developed sensor was 1 ng/ml which competes with the detection limit of gas chromatography -mass spectrometry investigated in this study.

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Section: Resultsmentioning

confidence: 99%

Highly Sensitive and Selective Detection of the Antidepressant Amitriptyline Using a Functionalised Graphene‐Based Sensor

2022

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“…This may be attributed to the available active sites of copper sulfides. In the case of chitosan- and Nafion-based electrodes, these polymers blocked some of them, as also indicated by decreased values of EASA and higher Warburg impedance modulus [ 14 , 46 ]. The small background current reducing LOD and LOQ for Cu-PVP/GCE may be explained by its lower CPE CT compared to that of other electrodes [ 20 ].…”

Section: Resultsmentioning

confidence: 99%

“…One of the most powerful tools for evaluating the characteristics of an electrochemical system is electrochemical impedance spectroscopy (EIS). This technique offers the possibility of studying the state of the electrode during various processes that occur in electrochemical experiments, such as adsorption, charge, and mass transport [ 12 , 13 , 14 , 15 ]. Moreover, the changes introduced by the modification of the substrate electrode with various conductive or nonconductive materials can be assessed using this technique [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Characterization of Modified Glassy Carbon Electrodes for Non-Enzymatic Glucose Sensors

Mazurków

Kusior

Radecka

2021

Sensors

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The diversity of materials proposed for non-enzymatic glucose detection and the lack of standardized protocols for assessing sensor performance have caused considerable confusion in the field. Therefore, methods for pre-evaluation of working electrodes, which will enable their conscious design, are currently intensively sought. Our approach involved comprehensive morphologic and structural characterization of copper sulfides as well as drop-casted suspensions based on three different polymers—cationic chitosan, anionic Nafion, and nonionic polyvinylpyrrolidone (PVP). For this purpose, scanning electron microscopy (SEM), X-ray diffraction (XRD), and Raman spectroscopy were applied. Subsequently, comparative studies of electrochemical properties of bare glassy carbon electrode (GCE), polymer- and copper sulfides/polymer-modified GCEs were performed using electrochemical impedance spectroscopy (EIS) and voltammetry. The results from EIS provided an explanation for the enhanced analytical performance of Cu-PVP/GCE over chitosan- and Nafion-based electrodes. Moreover, it was found that the pH of the electrolyte significantly affects the electrocatalytic behavior of copper sulfides, indicating the importance of OHads in the detection mechanism. Additionally, diffusion was denoted as a limiting step in the irreversible electrooxidation process that occurs in the proposed system.

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“…However, the production cost of synthetic zeolites may restrict their industrial use. 15,16 The main uses of natural zeolites are as cement additive, 17 nutrient-release agent, 18 catalyst, 19 adsorbent, 20,21 ion-exchanger, 22,23 bactericides, 24 hybrid membranes, 25,26 electrodes, 27,28 capacitors and sensors, 29,30 or even in energy storage processes. 31,32 Since zeolites are considered inert materials and not harmful to the environment, 33,34 they are directly connected to the green technologies platform seeking environmental protection.…”

Section: Introductionmentioning

confidence: 99%

The ‘chimie douce’ process towards the modification of natural zeolites for removing drugs and pesticides from water

Viotti

Moreira

Straioto

et al. 2022

J of Chemical Tech & Biotech

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BACKGROUND Drugs and pesticides are emerging contaminants, and their presence in surface and groundwater have been increasing. Therefore, this work aims to study the modification of natural zeolite to remove these contaminants from water. RESULTS Among the modifications carried out, hydrothermal treatment in the presence of surfactant (CTAB) was highlighted. The hydrothermal treatment with surfactant provided a structural rearrangement. As a result, the zeolite became more hydrophobic, with a smaller specific area and a more significant amount of mesopores and macropores. Changes in textural and chemical characteristics resulted in a significant increase in the removal of the evaluated pesticides and drugs. In order to evaluate the potential of zeolites to remove emerging contaminants under conditions closer to reality, the modified samples were evaluated in the adsorption process of simulated contaminated water. The maximum adsorption capacities obtained were 28.24, 3.07, and 20.06 mg g−1 for 2,4‐D, diuron, and diclofenac, respectively, using HT‐H2O_CTAB under conditions closer to real water treatment (30 °C and natural pH of the solution). CONCLUSION The results demonstrate that hydrothermal modification with CTAB is a promising ‘chimie douce’ technique to use natural zeolites to remove emerging contaminants. © 2022 Society of Chemical Industry (SCI).

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Application of Fe(III)-exchanged clinoptilolite/graphite nanocomposite for electrochemical sensing of amitriptyline

Cited by 19 publications

References 46 publications

Highly Sensitive and Selective Detection of the Antidepressant Amitriptyline Using a Functionalised Graphene‐Based Sensor

Highly Sensitive and Selective Detection of the Antidepressant Amitriptyline Using a Functionalised Graphene‐Based Sensor

Electrochemical Characterization of Modified Glassy Carbon Electrodes for Non-Enzymatic Glucose Sensors

The ‘chimie douce’ process towards the modification of natural zeolites for removing drugs and pesticides from water

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