Application of EARL (ResEARch 4 Life®) protocols for [18F]FDG-PET/CT clinical and research studies. A roadmap towards exact recovery coefficient

Balcerzyk, Marcin; Fernández-López, Rosa; Parrado-Gallego, Ángel; Pachón-Garrudo, V.M.; Royan, José Chavero; Hevilla, Juan; Jiménez-Ortega, Elisa; Leal, Antonio

doi:10.1016/j.nima.2017.04.035

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…As it was mentioned above, DP requires repeatability and reproducibility in PET acquisition settings and data analysis methods in order to be able to normalize the prescription dose. For a previous work we achieved the EARL European accreditation for the PET/CT scanner used in this study [24], in order to obtain the needed precision and accuracy for a consensual prescription of the dose. After multiple measurements with the image quality phantom NEMA 2–2007 [25], we established the image reconstruction protocol able to achieve the EARL accreditation.…”

Section: Methodsmentioning

confidence: 99%

Accurate, robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy

et al. 2019

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In this work we present a methodology able to use harmonized PET/CT imaging in dose painting by number (DPBN) approach by means of a robust and accurate treatment planning system. Image processing and treatment planning were performed by using a Matlab-based platform, called CARMEN, in which a full Monte Carlo simulation is included. Linear programming formulation was developed for a voxel-by-voxel robust optimization and a specific direct aperture optimization was designed for an efficient adaptive radiotherapy implementation. DPBN approach with our methodology was tested to reduce the uncertainties associated with both, the absolute value and the relative value of the information in the functional image. For the same H&N case, a single robust treatment was planned for dose prescription maps corresponding to standardized uptake value distributions from two different image reconstruction protocols: One to fulfill EARL accreditation for harmonization of [18F]FDG PET/CT image, and the other one to use the highest available spatial resolution. Also, a robust treatment was planned to fulfill dose prescription maps corresponding to both approaches, the dose painting by contour based on volumes and our voxel-by-voxel DPBN. Adaptive planning was also carried out to check the suitability of our proposal.Different plans showed robustness to cover a range of scenarios for implementation of harmonizing strategies by using the highest available resolution. Also, robustness associated to discretization level of dose prescription according to the use of contours or numbers was achieved. All plans showed excellent quality index histogram and quality factors below 2%. Efficient solution for adaptive radiotherapy based directly on changes in functional image was obtained. We proved that by using voxel-by-voxel DPBN approach it is possible to overcome typical drawbacks linked to PET/CT images, providing to the clinical specialist confidence enough for routinely implementation of functional imaging for personalized radiotherapy.

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Section: Methodsmentioning

confidence: 99%

Accurate, robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy

et al. 2019

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“…Spherical volume of interest (VOI) was drawn manually on the slice mentioned above with a diameter as close as possible to the sphere diameter. Since the reconstruction setting leads to the variation of volume of interest, spherical VOI was drawn in the PET images as closely as possible to the true volume of the sphere in CT images (25)(26)(27). After that, RC was obtained by dividing the measured activity concentration by the true activity concentration.…”

Section: Quantitative Metricsmentioning

confidence: 99%

Multicenter quantitative 18F-fluorodeoxyglucose positron emission tomography performance harmonization: use of hottest voxels towards more robust quantification

Vosoughi¹,

Momennezhad²,

Emami³

et al. 2023

Quant Imaging Med Surg

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Background: Harmonization methods reduce variability between different make and models of positron emission tomography (PET) scanners. The study aims to explore harmonization strategies that lead to comparable and robust quantitative metrics in a multicenter setting.Methods: NEMA IEC Phantom data acquisition was performed for low and high spheres-to-background ratios (SBR4:1 and 10:1) on six PET/CT (computed tomography) scanners. Different reconstruction sets, including the number of sub-iterations, number of subsets, and full width at half maximum (FWHM) for each scanner, were evaluated towards optimized and harmonized reconstruction settings. Recovery coefficients (RCs) of four quantitative metrics, including standardized uptake value (SUV) max , SUV (SUV mean in 50% isocontour), SUV peak , and mean uptake of 10 highest concentration voxels were evaluated as RC max , RC ISO-50 , RC peak , and RC 10V , representing percent difference relative to the static ground truth case as functions of sphere sizes. A set of image reconstruction parameters was proposed for harmonized reconstruction to minimize variability between scanners. The root mean square error (RMSE), curvature, and reproducibility were examined. The proposed reconstruction protocols for harmonization and standard clinical reconstruction settings were compared to each other across all scanners.Results: A significant difference (P value <0.0001) was observed in the aforementioned quantitative metrics between SBR10 and SBR4. Reconstruction parameter sets with the smallest RMSE and RC values within 10% bias were identified as the best candidate for harmonization. The coefficient of variation of the mean value of RCs (CV MRC ) shows a remarkable reduction of about 28%, 26%, 32%, and 19% in harmonized reconstruction settings for MRC max , MRC ISO-50 , MRC peak , and MRC 10V , respectively. CV MRC for MRC 10V in the harmonized reconstruction setting was 5.9% in SBR4, while the smallest value in SBR10 belongs to MRC peak, with a value of 5.8%. The reproducibility of RC is improved by deriving the value from ten hottest voxels and is equally reproducible with RC peak . Compared to RC max and RC ISO-50 , the variability is reduced by 18% and 22% if ten voxels are pooled.

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“…For this work, the PET/CT scanner used was the Siemens Biograph mCT 64 model. This device achieved EARL1 accreditation in 2017 [27]. The image reconstruction protocol that met accreditation criteria did not achieve the best resolution that the equipment could provide, underexploiting its capabilities.…”

Section: New Earl Accreditationmentioning

confidence: 99%

Implications of the Harmonization of [18F]FDG-PET/CT Imaging for Response Assessment of Treatment in Radiotherapy Planning

et al. 2022

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The purpose of this work is to present useful recommendations for the use of [18F]FDG-PET/CT imaging in radiotherapy planning and monitoring under different versions of EARL accreditation for harmonization of PET devices. A proof-of-concept experiment designed on an anthropomorphic phantom was carried out to establish the most suitable interpolation methods of the PET images in the different steps of the planning procedure. Based on PET/CT images obtained by using these optimal interpolations for the old EARL accreditation (EARL1) and for the new one (EARL2), the treatment plannings of representative actual clinical cases were calculated, and the clinical implications of the resulting differences were analyzed. As expected, EARL2 provided smaller volumes with higher resolution than EARL1. The increase in the size of the reconstructed volumes with EARL1 accreditation caused high doses in the organs at risk and in the regions adjacent to the target volumes. EARL2 accreditation allowed an improvement in the accuracy of the PET imaging precision, allowing more personalized radiotherapy. This work provides recommendations for those centers that intend to benefit from the new accreditation, EARL2, and can help build confidence of those that must continue working under the EARL1 accreditation.

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Application of EARL (ResEARch 4 Life®) protocols for [18F]FDG-PET/CT clinical and research studies. A roadmap towards exact recovery coefficient

Cited by 4 publications

References 8 publications

Accurate, robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy

Accurate, robust and harmonized implementation of morpho-functional imaging in treatment planning for personalized radiotherapy

Multicenter quantitative 18F-fluorodeoxyglucose positron emission tomography performance harmonization: use of hottest voxels towards more robust quantification

Implications of the Harmonization of [18F]FDG-PET/CT Imaging for Response Assessment of Treatment in Radiotherapy Planning

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