Application of Dual Ionic/Covalent Crosslinking in Lecithin/ Chitosan Nanoparticles and Their Evaluation as Drug Delivery System

Dmour, Isra; Muti, H.

doi:10.32383/appdr/131660

Cited by 4 publications

(5 citation statements)

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“…Damour I. and Muti H., (2021) succeeded in obtaining stable CPH based on lecithin/CS conjugates via a dual ionic/covalent crosslinking method. They found that the dual ionic/covalent crosslinking improved nanoparticles’ drug loading/releasing properties [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications

Savin

Delaite

Tiron

et al. 2022

Gels

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Chitosan (CS) crosslinking has been thoroughly investigated, but the chemical reactions leading to submicronic hydrogel formulations pose problems due to various physical/chemical interactions that limit chitosan processability. The current study employs the chemical modification of chitosan by Michael addition of poly (ethylene glycol) methyl ether acrylate (PEGA) to the amine groups to further prepare chitosan particulate hydrogels (CPH). Thus, modified CS is subjected to a double crosslinking, ionic and covalent, in water/oil emulsion. The studied process parameters are polymer concentration, stirring speed, and quantity of ionic crosslinker. The CPH were structurally and morphologically characterized through infrared spectroscopy, scanning electron microscopy, light scattering granulometry, and zeta potential, showing that modified CS allows better control of dimensional properties and morphology as compared with neat CS. Swelling properties were studied in acidic and neutral pH conditions, showing that pH-dependent behavior was maintained after grafting and double crosslinking. The applicability of the prepared materials was further tested for drug loading and in vitro delivery of levofloxacin (LEV), showing excellent capacity. CPH were found to be cyto- and hemocompatible demonstrating their potential for effective use as a controlled release system for different biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications

Savin

Delaite

Tiron

et al. 2022

Gels

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“…Borax, when utilized as a crosslinking agent, contributed to an increase in both loading capacity and loading efficiency. The degree of crosslinking increases with increasing borax concentration, thereby facilitating the entrapment of a greater quantity of drugs during the drug-loading procedure [ 46 ]. GSNO decomposed by approximately 50% at −20 °C on the 28th day of storage compared to its initial state.…”

Section: Discussionmentioning

confidence: 99%

The Formulation and Characterization of Wound Dressing Releasing S-Nitrosoglutathione from Polyvinyl Alcohol/Borax Reinforced Carboxymethyl Chitosan Self-Healing Hydrogel

Palungan,

Luthfiyah,

Mustopa

et al. 2024

Pharmaceutics

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Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. Self-healing hydrogel mechanical properties were improved via polymer blends. Applying this hydrogel to the wound site allows it to self-heal and reattach after mechanical damage. This work evaluated polyvinyl alcohol (PVA)-based self-healing hydrogels with borax as a crosslinking agent and carboxymethyl chitosan as a mechanical property enhancer. Three formulations (F1, F4, and F7) developed self-healing hydrogels. These formulations had borax concentrations of 0.8%, 1.2%, and 1.6%. An FTIR study shows that borate ester crosslinking and hydrogen bonding between polymers generate a self-healing hydrogel. F4 has a highly uniform and regular pore structure, as shown by the scanning electron microscope image. F1 exhibited faster self-healing, taking 13.95 ± 1.45 min compared to other formulations. All preparations had pH values close to neutrality, making them suitable wound dressings. Formula F7 has a high drug content (97.34 ± 1.21%). Good mechanical qualities included high tensile stress–strain intensity and Young’s modulus. After 28 h of storage at −20 °C, 5 °C, and 25 °C, the self-healing hydrogel’s drug content dropped significantly. The Korsmeyer–Peppas release model showed that the release profile of GSNO followed Fickian diffusion. Thus, varying the concentration of crosslinking agent and adding a polymer affects self-healing hydrogels’ physicochemical properties.

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“…In addition, the particle charge (zeta-potential) has a large impact on surface recognition, surface interaction with biomolecules, and cellular targeting. Importantly, size and zetapotential contribute significantly to the NP storage stability [79,80]. The need for a monodisperse NP dispersion mandate the use of very advanced and facile methods that facilitate monitoring of NP size over time and following exposure to changes in temperature and pHs.…”

Section: Particle Size Distribution and Determination And Surface Chargementioning

confidence: 99%

“…Published data related to NBC size characterization include but are not limited to grafted pectin [13], chitosan phthalate and phenyl succinate [7,79], thiolated chitosan [5], chitosan [30,85], cellulose [86] and many others.…”

Section: Figure 27 Water Contact Angles Of Nbcs Based On Bacterial Ce...mentioning

confidence: 99%

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Physicochemical Characterization of Nanobiocomposites

Dmour¹

2022

Biocomposites - Recent Advances [Working Title]

Self Cite

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Nanobiocomposites (NBCs) have many applications in drug delivery, tissue engineering, etc. The need for NBC physicochemical characterization is mandatory before investigating their usefulness in developing drug delivery systems. This chapter will explore the basic and the most recent techniques used in the physicochemical characterization of these biocomposites. Examples of physical properties include morphological properties using microscopy (size, porosity, etc.), particle size analysis and surface charge, powder X-ray diffraction, thermal, mechanical, and rheological properties, etc. Examples of chemical properties include molecular weight determination, solubility and purity assessment, degree of functionalization, and gelling properties, using spectroscopic techniques (UV, MS, NMR, etc.). For each property, the following points will be elucidated: sample preparation, factors affecting the accuracy of the test results, examples of data interpretation from the recently published literature, and test limitations, if any.

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Application of Dual Ionic/Covalent Crosslinking in Lecithin/ Chitosan Nanoparticles and Their Evaluation as Drug Delivery System

Cited by 4 publications

References 0 publications

Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications

Chitosan Grafted Poly (Ethylene Glycol) Methyl Ether Acrylate Particulate Hydrogels for Drug Delivery Applications

The Formulation and Characterization of Wound Dressing Releasing S-Nitrosoglutathione from Polyvinyl Alcohol/Borax Reinforced Carboxymethyl Chitosan Self-Healing Hydrogel

Physicochemical Characterization of Nanobiocomposites

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