Application of concentrated growth factor to autotransplantation with inflammation in recipient area

Abstract

Objective The purpose of this study was to apply concentrated growth factor (CGF) to the transplanted area with inflammation, to observe the clinical effects of CGF on the inflammation area assisted by 3D printing technology. Methods A total of 52 compromised mandibular first or second molar with chronic periapical lesions were transplanted with mature third molars. The patients were divided into CGF group (n = 26) and control group (n = 26) and transplanted into fresh extraction sockets with or without CGF. All the patients underwent clinical and radiographic examinations during the follow-up. Results Average surgery and extra-oral time were 39 min (± 7.8) and 42 s (± 10.2). The success rates of CGF group and control group were 100% and 92.3% respectively. Most of the periapical lesions in CGF group healed completely within 3 months, which was significantly faster than control group. The initial stability of CGF group was better than control group immediately after operation, and the degree of pain in CGF group was lower than control group on the 1st and 3rd day after operation. Conclusions The application of CGF in recipient site with chronic periapical lesions can accelerate the regeneration of alveolar bone and the healing of inflammation, greatly shorten the healing period. Meanwhile, CGF help to reduce postoperative pain and reaction at the early stage of healing and increase the success rate of autogenous tooth transplantation (ATT). Additionally, the use of 3D printing model can greatly reduce the extra-oral time of donor teeth.

Clinical application of concentrate growth factors combined with bone substitute in Alveolar ridge preservation of anterior teeth

“…Therefore, when ready to insert dental implant, the CGF group has better alveolar ridge condition, more bone volume, and better surgical environment. Many other studies have shown that CGF can accelerate bone healing [ 14 , 16 , 35 – 37 ]. Among them, Kim et al [ 14 ] applied CGF in sinus augmentation without any graft materials and confirmed respectively that CGF was effective in promoting healing of bone and can induce new bone formation rapidly.…”

“…Among them, Kim et al [ 14 ] applied CGF in sinus augmentation without any graft materials and confirmed respectively that CGF was effective in promoting healing of bone and can induce new bone formation rapidly. Our previous research showed that the application of CGF in recipient site with a small area of chronic periapical lesions can accelerate the regeneration of alveolar bone and the healing of inflammation, greatly shorten the healing period [ 35 ]. Fang et al [ 36 ] found that the combinational use of CGFs with DBBM could promote new bone regeneration without adding exogenous stem cells in bilateral maxillary sinus floor augmentation, which yields effects similar to combining BMSCs with DBBM.…”

Mechanisms of bone remodeling and therapeutic strategies in chronic apical periodontitis

“…Bone regeneration at the newly formed wound after endodontic surgery is an important step in periapical restoration (Montero-Miralles et al, 2021). The application of CGF or stem cells is an effective means to ensure a rapid and successful recovery of the diseased periapical area after surgery (Keranmu et al, 2021).…”

“…CGF is mainly composed of concentrated platelets, white blood cells, cytokines, and fibrin with a reticular structure, and is prepared with relation to the coagulation of blood. CGF contains TGF-1, platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and insulin-like growth factor-1 (IGF-1), among others (Keranmu et al, 2021;Vaid et al, 2021). The scaffold network structure of CGF slows the release of the growth factors.…”

Unusual Indications of Teeth Transplantation: A Literature Review

“…The bulk of published literature on dental transplantation describes autogenous transplantation of teeth within various conditions and indications as a reliable treatment option [1][2][3][4][5][6][7][12][13][14][15][16][17][18][19][20][21]. Allogenic dental transplantation cases, where donor and recipient are two different individuals, are scarce in the medical literature due to several reasons.…”