1977
DOI: 10.1136/jmg.14.5.362
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Application of chromosome banding techniques to the study of primary chromosome structural changes.

Abstract: SUMMARY Some comments are provided for the benefit of new workers on the use of chromosome banding techniques for the recognition, classification, scoring, and break point location of primary chromosomal structural changes.

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Cited by 38 publications
(15 citation statements)
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“…The del(5q) then must have arisen more than once within the population (since it is present in both clones), which does not fit with the theory of monoclonality in cancer. However, since a del(5q) is a frequent anomaly in cancer compared with the probability of a second, independent random event involving the same two bands (~ I0 ", as calculated by Savage, 1977), a predisposition could exist for an interstitial deletion of this chromosome segment, making the possibility of it arising more than once within the marrow plau sible.…”
Section: Discussionmentioning
confidence: 99%
“…The del(5q) then must have arisen more than once within the population (since it is present in both clones), which does not fit with the theory of monoclonality in cancer. However, since a del(5q) is a frequent anomaly in cancer compared with the probability of a second, independent random event involving the same two bands (~ I0 ", as calculated by Savage, 1977), a predisposition could exist for an interstitial deletion of this chromosome segment, making the possibility of it arising more than once within the marrow plau sible.…”
Section: Discussionmentioning
confidence: 99%
“…For example, chromosome 21 often has a single chiasma in the junction q21/q22, while that on chromosome 22 is more often more proximal, in the junction q ll/q l2 . Evidently, the same lack of accuracy that plagues positioning of mitotic break points by chromosome banding (Savage, 1977) also affects the "band-specific" localization of chiasmata ( fig. 9c).…”
Section: Clustering Of Chiasmatamentioning
confidence: 99%
“…D utriixaux et al (1978) have even claimed that the banding homol ogy between the Cercopithecinae and man is complete. Although such claims cannot be accepted or rejected until they are sub stantiated by gene mapping studies, the structural rearrangements proposed by these authors seem exceedingly complex and quite often fall within the three band uncertainty zone described by Savage (1977).…”
Section: Discussionmentioning
confidence: 99%