Application of chiral chromatography in radiopharmaceutical fields: A review

Moein, Mohammad Mahdi; Tran, Thuy

doi:10.1016/j.chroma.2020.461611

Cited by 8 publications

(1 citation statement)

References 148 publications

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“…These include separation of enantiomers in various techniques such as GC, , HPLC, , SFC, capillary electrophoresis (CE), ,, capillary electrochromatography (CEC), and microchip-based platforms . Another set of review papers deal with specific types of CSs, such as polysaccharide derivatives, , glycopeptide antiobiotics, − CDs, − Pirkle-type, chiral ion-exchangers, and MOFs. ,, One more group of review papers deals with high-resolution and fast separations, , chiral recognition mechanisms, ,,− and molecular modelling. − ,,− There are also review papers published on various aspects of application of enantioseparations, in particular about preparative and product scale separations, − enantioselective pharmaceutical, − biomedical, ,− environmental, , and food and beverage analysis . The narrative thread of all the above-mentioned methods, techniques, and applications is that they are all based on the enantioselective noncovalent interaction between two counterparts, of which one is called analyte, selectand, guest, or ligand and the other is called the selector, host, or receptor.…”

Section: Trends In Enantioselective Recognition In Separation Science...mentioning

confidence: 99%

Recognition in the Domain of Molecular Chirality: From Noncovalent Interactions to Separation of Enantiomers

2022

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It is not a coincidence that both chirality and noncovalent interactions are ubiquitous in nature and synthetic molecular systems. Noncovalent interactivity between chiral molecules underlies enantioselective recognition as a fundamental phenomenon regulating life and human activities. Thus, noncovalent interactions represent the narrative thread of a fascinating story which goes across several disciplines of medical, chemical, physical, biological, and other natural sciences. This review has been conceived with the awareness that a modern attitude toward molecular chirality and its consequences needs to be founded on multidisciplinary approaches to disclose the molecular basis of essential enantioselective phenomena in the domain of chemical, physical, and life sciences. With the primary aim of discussing this topic in an integrated way, a comprehensive pool of rational and systematic multidisciplinary information is provided, which concerns the fundamentals of chirality, a description of noncovalent interactions, and their implications in enantioselective processes occurring in different contexts. A specific focus is devoted to enantioselection in chromatography and electromigration techniques because of their unique feature as “multistep” processes. A second motivation for writing this review is to make a clear statement about the state of the art, the tools we have at our disposal, and what is still missing to fully understand the mechanisms underlying enantioselective recognition.

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