Application of catheter-tip i.s.f.e.t. for continuousin vivo measurement

Shimada, Kazuki; Yano, Makoto; Shibatani, Kyoichiro; Komoto, Yoshiaki; Esashi, M.; Matsuo, Tadayuki

doi:10.1007/bf02441899

Cited by 83 publications

(19 citation statements)

References 3 publications

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“…Since respiratory oscillations of arterial pH are thought to reflect the respiratory CO2 oscillations, we measured in vivo arterial pH continuously by a rapidly responding catheter tip ISFET (ion-sensitive field effect transistor) pH electrode (63°c response 120 ms; Kuraray, PH-1035) in which a small H + sensitive ISFET (5.5 x 0.4 x 0.15 mm) is encapsulated in a flexible catheter (35 cm length, 0.65 mm OD; SHIMADA et al, 1980). A thermistor is also fabricated on the same semiconductor chip, providing direct measurement of temperature at the site of pH measurement.…”

Section: Methodsmentioning

confidence: 99%

Role of carbon dioxide oscillation in the control of respiration in the anesthetized dog.

Takahashi

Ashe

1989

Jpn.J.Physiol

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In order to examine the role of respiratory oscillation of Paco2 (CO2 oscillation) in the control of respiration, we performed veno-venous bypass using a membrane lung in 10 anesthetized paralyzed dogs, where the dog was put on fixed mechanical ventilation so that we could keep average Paco2 and Pa02 constant by adjusting FIco2 and Fio2 during CO2 loading/unloading. By venous CO2 loading/unloading we could widely change the CO2 output from the lung (11-440 of the control) resulting in large changes in the arterial CO2 oscillations (50-280% of the control for the maximum rate of rise of Paco2 and 40-350°c of the control for the maximum rate of fall of Paco2), which was measured by a rapidly responding intra-arterial pH electrode. Despite such wide variations in CO2 oscillations we did not find any consistent change in the respiratory center output (minute phrenic activity). This held true after compensating the changes in the minute phrenic activity for the CO2 sensitivity of each individual dog. Thus, the present results may suggest that the CO2 oscillation plays little role in the control of respiration in mild increase in Vco2.

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Section: Methodsmentioning

confidence: 99%

Role of carbon dioxide oscillation in the control of respiration in the anesthetized dog.

Takahashi

Ashe

1989

Jpn.J.Physiol

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“…• Maximum adhesion between the encapsulant and the sensor chip for minimizing moisture penetration. Glass [2], polyimide [3] and silicone [4] are amongst the encapsulation materials reported in the literature. Also, water resistant epoxies [5] are quite popular due to their ease of handling.…”

Section: Encapsulation Techniques and Materialsmentioning

confidence: 99%

Batch encapsulation technique for CMOS based chemical sensors

Prodromakis

Georgiou

Constandinou

et al. 2008

2008 IEEE Biomedical Circuits and Systems Conference

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“…The sensor is very attractive for continuous, implantable monitoring applications [130][131] due to its advantages including small size, low-power consumption, robustness, compatibility with on-chip circuit integration for signal processing [132,133], and the significantly low cost associated with batch fabrication using IC technology, as well as mass production of biomembranes [130]. Evolution of the sensor integration can be realized by IC fabrication techniques, in which several different structures [134][135], encapsulation techniques [136][137][138], sensing materials for multi-ions such as H + , Na + , K + and Ca 2+ [139] and pH-ISFETs integrated with standard CMOS processes [140] have been investigated. Advanced micro-and nanofabrication technology and microelectronics, make miniaturization of ISFETs very feasible.…”

Section: Implantable Isfetsmentioning

confidence: 99%

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

Dong²,

Cao³

et al. 2007

CMC

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Biosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.

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Application of catheter-tip i.s.f.e.t. for continuousin vivo measurement

Cited by 83 publications

References 3 publications

Role of carbon dioxide oscillation in the control of respiration in the anesthetized dog.

Role of carbon dioxide oscillation in the control of respiration in the anesthetized dog.

Batch encapsulation technique for CMOS based chemical sensors

Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities.

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