Application of bone marrow samples for discrimination of acute promyelocytic leukemia from other types of acute leukemia using the routine automated hematology analyzer

Abstract

Delta neutrophil index and LUC in BM showed discriminating power of APL cells from other leukemia cells.

The diagnostic use of ADVIA 2120i Siemens and an “APL criteria” can help to reduce the rate of early death in the APL

“…Another study led to design of a diagnostic algorithm for APL using as parameters the percentage of large unstained cells (LUC) and delta neutrophil index (DNI), but this work has been done on bone marrow aspiration fluid …”

‘Complete blood counts and automated leucocyte differential results obtained by Siemens ADVIA 2120i in 145 cases of acute leukaemia in adults: insights into cellular pathophysiology and differential diagnosis’

“…The qualitative review of cytogram 'morphology' performed to assist in the identification of cellular abnormalities is a well-known example of how automated haematology analysers changed laboratory practice during the past decades [2]. As a matter of fact, cytogram interpretation has been traditionally included in differential diagnostic procedures used to distinguish between acute myeloid and lymphoid leukaemias [3,4], which could be regarded as distinct entities from molecular, cellular and clinical perspectives [5,6]. Indeed, except for cases with pathognomonic morphological features (e.g.…”

Automated cytochemistry expanded using novel cellular analysis

“…Sir, we would like to join d'Onofrio & Zini [1] in congratulating Jang et al upon their recent publication [2]. The ability of modern analytical platforms to offer clues to the potential diagnosis of acute promyelocytic leukemia (APL) should not be overlooked.…”