Application of biological activity of oxazepine and 2-azetidinone compounds and study of their liquid crystalline behavior

In this study, new tetrazole [A1-A5] were prepared by the reaction of Schiff base with sodium azide in tetrahydrofuran (THF) by the traditional method (reflux) and microwave technology. The prepared compounds were characterized by physical properties, UV-Vis, FT-IR, 1H-NMR, 13C-NMR spectral, and C.H.N analysis. TLC checked the purity of these compounds. Antibacterial behaviors were investigated against a variety of bacteria, including Escherichia coli, and Klebsiella pneumonia Gram (-) ve, Staphylococcus aureus, and Staphylococcus epidermidis Gram (+) ve. The laser efficacy of the [A1-A5] was evaluated after they were radiated by laser for (10, 20, 30) seconds. As the melting point, and color of the substances were determined, it was discovered that they were unaffected, and did not disintegrate or polymerize. Using the Chem3D 19.0 program, the heat of the formulation of the [A1-A5] was investigated.

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“…This indicates that the substances were untouched by the laser beams. They are secure, as shown by table (6) [19].…”

Section: Lasers' Impact On Prepared Compounds [A 1 -A 5 ]mentioning

confidence: 99%

Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Dalaf

Jumaa

Aftana

et al. 2022

KEM

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“…The only difference is the number of the carbon atom in the ring which could show a difference bioactivity δ-lactam is a subgroup of lactam family that widely used in and medicine and pharmaceutical chemistry [9]. On the other hand, oxazepine compounds have previously shown an inclusive range of applications in the pharmaceutical industry, including antidepressants, enzyme inhibitors, and palliative effects [10]. They are unsaturated heterocycles compounds comprising of seven atoms where two substituted by a nitrogen and oxygen atom respectively [3].…”

Section: Introductionmentioning

confidence: 99%

Synthesizes, characterization, molecular modelling studies and bioactivity of a novel bicyclic compound of δ-lactam with oxazepine ring containing-sulphur substitute using an economic method

Muslim

Guma

Abedulrahman

et al. 2023

Preprint

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Penicillin resistance is a commonly present and controversial matter due to the misuses by people for various reasons. However, little studies have been examined the bioactivity of the 5 and 6 membered rings. In this study, we aimed to synthesize a new compound contain 5- membered ring following a short and low cost method and combined it with oxazepine ring via Schiff bases to produce a bicyclic molecule (Lactozepine). In vitro examinations were implemented to assess the bioactivity of the prepared compound such as anti-bacterial, anti-fungal and anti-oxidant which has shown a wide zone of inhibition of lactozepine against Streptococcus pneumoniae but no inhibition was shown against Kelbesilla pneumoniae and Staphylococcus aureus except at a high concentration similar to the result of the anti-fungal assessment. Furthermore, lactozepine showed worthy anti-oxidant activity against free radical formation. The molecular modelling and docking assessment showed availability of lactozepine to bind to bacterial proteins and inhibit their growth with lowest free energy for the greatest and strong binding affinity with the PDB crystal structures 1VQQ, 2WAE, 1PYY and 1IYS were between − 6.5 and − 7.9 kcal/mol. Moreover, the molecular MD dynamic simulation showed that RMSF (root mean square fluctuation) for the assessed protein's amino acids remained consistent and tightly bound to lactozepine in the dynamic state. The novel compound of lactozepine having δ-lactam rings attached to oxazepine showed a bioactivity that are hopeful for in vivo studies in the future.

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“…As shown in figure (4). In addition, the 1 H-NMR (400 MHz, Chloroformd) δ/ppm to the [A5] Compound: (1.22 & 1.23) (d, 6H, 2CH3); 2.30 (s, 6H, 2CH3); (3.51, 3.52 & 3.53) (t, 2H, 2NH Imidazolidin-4-one); (3.91-3.95) (f, 2H, 2CH Imidazolidin-4-one); 6.09 (s, 2H, 2CH=C isoxazole); (6.25 & 6.27) (d, 2H, 2CH Imidazolidin-4-one); (6.99-7.95) (m, 22H, Aromatic benzene); 7.46 (s, Chloroformd); 8.31 (s, 2H, 2OH)[17]. As shown in figure(5).…”

mentioning

confidence: 99%

Preparation, Characterization, Biological Evaluation and Assess Laser Efficacy for New Derivatives of Imidazolidin-4-one

Dalaf

Jumaa

Salih

2021

Int. Res. J. multidiscip. Technovation

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In this study, new Imidazolidin-4-one [A1-A5] compounds were prepared by the reaction of schiff base compounds with alanine in ethanol. The prepared compounds were characterized by physical properties, UV-Vis, FT-IR and 1H-NMR spectral and C.H.N analysis. TLC checked the purity for these compounds. All compounds [A1-A5] were prepared by the traditional method (reflux) and microwave technology. It was found that using the microwave method gives better results in terms of less time and, higher yield. Antibacterial behaviors were investigated against a variety of bacteria, including Escherichia coli and Klebsiella pneumonia Gram (-) ve, Staphylococcus aureus, and Staphylococcus epidermidis Gram (+) ve. The laser efficacy of the compounds [A1-A5] was evaluated after they were radiated by laser for (10, 20, 30) seconds. As the melting point and color of the substances were determined, it was discovered that they were unaffected and did not disintegrate or polymerize. Using the Chem Draw Specialist 19.0 program, the stereoisomers of the prepared compounds [A1-A5] were examined at the lowest layer stage. Using the Chem3D 19.0 program, the heat of the formulation of the compounds [A1-A5] was also investigated.

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Application of biological activity of oxazepine and 2-azetidinone compounds and study of their liquid crystalline behavior

Cited by 5 publications

References 15 publications

Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole

Synthesizes, characterization, molecular modelling studies and bioactivity of a novel bicyclic compound of δ-lactam with oxazepine ring containing-sulphur substitute using an economic method

Preparation, Characterization, Biological Evaluation and Assess Laser Efficacy for New Derivatives of Imidazolidin-4-one

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