Application of APTES-Anti-E-cadherin film for early cancer monitoring

Ismail, Manel Ben; Carreiras, Franck; Agniel, Rémy; Mili, Donia; Sboui, Dejla; Zanina, Nahla; Othmane, Ali

doi:10.1016/j.colsurfb.2016.06.048

Cited by 5 publications

(1 citation statement)

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“…With its help, the traditional detection techniques, such as electron microscopy, small‐angle X‐ray scattering and mass spectroscopy method, could detect E-cadherin more easily. Interestingly, researchers have developed a novel electrochemical label-free immunosensor to identify the expression of E-cadherin by modifying indium-tin oxide electrodes with anti-E-cadherin monoclonal antibodies 40…”

Section: The Function and Detection Of E-cadherin In Cancermentioning

confidence: 99%

<p>Genetic And Epigenetic Regulation Of E-Cadherin Signaling In Human Hepatocellular Carcinoma</p>

Fan¹,

Jin²,

Li³

et al. 2019

CMAR

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E-cadherin is well known as a growth and invasion suppressor and belongs to the large cadherin family. Loss of E-cadherin is widely known as the hallmark of epithelial-tomesenchymal transition (EMT) with the involvement of transcription factors such as Snail, Slug, Twist and Zeb1/2. Tumor cells undergoing EMT could migrate to distant sites and become metastases. Recently, numerous studies have revealed how the expression of E-cadherin is regulated by different kinds of genetic and epigenetic alteration, which are implicated in several crucial transcription factors and pathways. E-cadherin signaling plays an important role in hepatocellular carcinoma (HCC) initiation and progression considering the highly mutated frequency of CTNNB1 (27%). Combining the data from The Cancer Genome Atlas (TCGA) database and previous studies, we have summarized the roles of gene mutations, chromosome instability, DNA methylation, histone modifications and non-coding RNA in E-cadherin in HCC. In this review, we discuss the current understanding of the relationship between these modifications and HCC. Perspectives on E-cadherin-related research in HCC are provided.

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Section: The Function and Detection Of E-cadherin In Cancermentioning

confidence: 99%