Application of Anti-Bovine CD2 Monoclonal Antibody to the Rosette Inhibition Test for Detection of Early Pregnancy Factor in Cattle.

Yoshioka, Koji; Iwamura, Shohkichi; Kamomae, Hideo

doi:10.1292/jvms.57.721

Cited by 7 publications

(4 citation statements)

References 20 publications

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“…In spite of the cumbersome nature of the assay, many groups have used it in a research capacity for specific investigations. Results have shown that EPF is present in serum of all species tested including mice, 8 humans, 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 sheep, 75 pigs, 61 , 76 cattle 77 , 78 and red deer 79 . A diagrammatic representation of the assay is shown in Cavanagh and Morton 80…”

Section: The Rosette Inhibition Test the Bioassay For Early Pregnancmentioning

confidence: 99%

Early pregnancy factor: An extracellular chaperonin 10 homologue

Morton

1998

Immunol Cell Biol

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Summary Early pregnancy factor (EPF) has been identi®ed as a homologue of chaperonin 10 (cpn10) with immunosuppressive and growth factor properties. As a homologue of cpn10, it belongs to the heat shock family of proteins (hsp) but, unlike other members of this family, EPF is detected extracellularly. Early pregnancy factor was ®rst discovered in pregnancy serum by the rosette inhibition test, and the novelty of its discovery was that its presence could diagnose pregnancy within 6±24 h of a fertile mating. As well as being a monitor of the presence of a viable embryo, it is necessary for embryonic survival. In this capacity it acts as both an immunosuppressant and growth factor. Early pregnancy factor is also a product of proliferating primary and neoplastic cells and functions as an autocrine growth factor both in vivo and in vitro. It has a modifying e ect on the outcome of experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Early pregnancy factor is considered to be one of the major factors involved in the modi®cation of multiple sclerosis observed during pregnancy.

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Section: The Rosette Inhibition Test the Bioassay For Early Pregnancmentioning

confidence: 99%

Early pregnancy factor: An extracellular chaperonin 10 homologue

Morton

1998

Immunol Cell Biol

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“…Early pregnancy factor (EPF) or early conception factor was fi rst reported by Morton et al ( 1974 ) in pregnant mice, and EPF has subsequently been reported in the serum of pregnant sheep (Morton et al 1979 ), pigs (Koch et al 1983 ), cattle (Yoshioka et al 1995 ), horses (Ohnuma et al 2000 ), red deer (Lash et al 1997 ), and humans (Morton et al 1977 ). EPF was identifi ed as a homologue to chaperonin 10 (Cavanagh and Morton 1994 ; Morton 1998 ) and is believed to suppress the maternal immune Kill et al ( 2013 ) b Dunne et al ( 2000 ), Silke et al ( 2002 ) c Stevenson et al ( 2003 ), Perry et al ( 2005 ), Pohler et al ( 2013 ) system, based on its activity in a rosette inhibition test (Morton et al 1987 ;Morton 1998 ).…”

Section: Early Pregnancy Factormentioning

confidence: 99%

Predicting Embryo Presence and Viability

Pohler

Green

Geary

et al. 2015

Regulation of Implantation and Establishment of Pregnancy in Mammals

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Pregnancy establishment, followed by birth of live offspring, is essential to all mammals. The biological processes leading up to pregnancy establishment, maintenance, and birth are complex and dependent on the coordinated timing of a series of events at the molecular, cellular, and physiological level. The ability to ovulate a competent oocyte, which is capable of undergoing fertilization, is only the initial step in achieving a successful pregnancy. Once fertilization has occurred and early embryonic development is initiated, early pregnancy detection is critical to provide proper prenatal care (humans) or appropriate management (domestic livestock). However, the simple presence of an embryo, early in gestation, does not guarantee the birth of a live offspring. Pregnancy loss (embryonic mortality, spontaneous abortions, etc.) has been well documented in all mammals, especially in humans and domestic livestock species, and is a major cause of reproductive loss. It has been estimated that only about 25-30% of all fertilized oocytes in humans result in birth of a live offspring; however, identifying the embryos that will not survive to parturition has not been an easy task. Therefore, investigators have focused the identification of products in maternal circulation that permit the detection of an embryo and assessment of its well-being. This review will focus on the advances in predicting embryonic presence and viability, in vivo.

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“…Early pregnancy factor (EPF) or early conception factor was fi rst reported by Morton et al ( 1974 ) in pregnant mice, and EPF has subsequently been reported in the serum of pregnant sheep (Morton et al 1979 ), pigs (Koch et al 1983 ), cattle (Yoshioka et al 1995 ), horses , red deer (Lash et al 1997 ), and humans (Morton et al 1977 ). EPF was identifi ed as a homologue to chaperonin 10 (Cavanagh and Morton 1994 ; Morton 1998 ) and is believed to suppress the maternal immune Table 13.2 Incidence of late embryonic mortality (LEM; > day 28 of gestation) in cattle system, based on its activity in a rosette inhibition test (Morton et al 1987 ;Morton 1998 ).…”

Section: Early Pregnancy Factormentioning

confidence: 99%

Regulation of Implantation and Establishment of Pregnancy in Mammals

Geisert¹,

Bazer²

2015

Advances in Anatomy, Embryology and Cell Biology

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Advances in Anatomy, Embryology and Cell Biology publishes critical reviews and state-of-the-art surveys on all aspects of anatomy and of developmental, cellular and molecular biology, with a special emphasis on biomedical and translational topics.The series publishes volumes in two different formats:• Contributed volumes, each collecting 5 to 15 focused reviews written by leading experts • Single-authored or multi-authored monographs, providing a comprehensive overview of their topic of research

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Application of Anti-Bovine CD2 Monoclonal Antibody to the Rosette Inhibition Test for Detection of Early Pregnancy Factor in Cattle.

Cited by 7 publications

References 20 publications

Early pregnancy factor: An extracellular chaperonin 10 homologue

Early pregnancy factor: An extracellular chaperonin 10 homologue

Predicting Embryo Presence and Viability

Regulation of Implantation and Establishment of Pregnancy in Mammals

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