Application of an automated multi-pH and multi-temperature platform for accelerated solution stability testing in supporting drug discovery

Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery

“…Thus, it is important to be able to screen for stability in solution at an early stage, ideally from small quantities of compound in the era of solution-only collections. Automated methods to measure solution stability and their applications in early drug discovery and development have previously been described in the literature, 3,4 using the advantages of high-performance liquid chromatography (HPLC) autosamplers. This article outlines a new, higher-throughput, automated method for measuring solution stability, validated and benchmarked versus current standards, with some illustrative examples of its applications in support of drug discovery.…”