“…Thus, it is important to be able to screen for stability in solution at an early stage, ideally from small quantities of compound in the era of solution-only collections. Automated methods to measure solution stability and their applications in early drug discovery and development have previously been described in the literature, 3,4 using the advantages of high-performance liquid chromatography (HPLC) autosamplers. This article outlines a new, higher-throughput, automated method for measuring solution stability, validated and benchmarked versus current standards, with some illustrative examples of its applications in support of drug discovery.…”