Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery

Gomez-Sanchez, Ruben; Besley, Stephen; Zeliku, Zoe; Young, Robert J.

doi:10.1177/2472555220931795

Cited by 5 publications

(1 citation statement)

References 23 publications

(30 reference statements)

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“…Analysing the stability of the drugs over time is very important to assure that the concentration remains constant and that the patient receives the correct dose. [61] In this section, the results obtained for the stability study are analysed. This study was based on pH and carvedilol concentration measurements at 0 and 60 days.…”

Section: Stability Studiesmentioning

confidence: 99%

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

Lomba,

Polo,

Martínez

et al. 2024

ChemistrySelect

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Carvedilol is used to treat chronic hypertension, chronic stable angina pectoris and concomitant treatment heart failure and class II of the Biopharmaceutics Classification System (low solubility and poor bioavailability). This drug is only formulated as tablets, and liquid oral formulations are not available on the market. In this work, several aqueous eutectic mixtures formed by xylitol, citric acid, sorbitol and glucose (HBD) and choline chloride as HBA have been used to improve the solubility. Additionally, SwissADME was used to obtain physicochemical and pharmacokinetic parameters to further knowledge on the ADME (absorption, distribution, metabolism and excretion) parameters for carvedilol.The results reveal that the solubility of carvedilol increases as the content of water decreases, and the mixture formed by citric acid and choline chloride (CACh10) was the most soluble. The stability study shows that carvedilol in DES is stable during the test time, as the maximum and minimum concentration losses were 19.0 % and 0.2 %, respectively. These results help advance the green and sustainable development of new medicines in the liquid state.

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Section: Stability Studiesmentioning

confidence: 99%

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

Lomba,

Polo,

Martínez

et al. 2024

ChemistrySelect

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Proteomics mining of cancer hallmarks on a single‐cell resolution

Zuo

Yang

et al. 2023

Mass Spectrometry Reviews

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Dysregulated proteome is an essential contributor in carcinogenesis. Protein fluctuations fuel the progression of malignant transformation, such as uncontrolled proliferation, metastasis, and chemo/radiotherapy resistance, which severely impair therapeutic effectiveness and cause disease recurrence and eventually mortality among cancer patients. Cellular heterogeneity is widely observed in cancer and numerous cell subtypes have been characterized that greatly influence cancer progression. Population‐averaged research may not fully reveal the heterogeneity, leading to inaccurate conclusions. Thus, deep mining of the multiplex proteome at the single‐cell resolution will provide new insights into cancer biology, to develop prognostic biomarkers and treatments. Considering the recent advances in single‐cell proteomics, herein we review several novel technologies with particular focus on single‐cell mass spectrometry analysis, and summarize their advantages and practical applications in the diagnosis and treatment for cancer. Technological development in single‐cell proteomics will bring a paradigm shift in cancer detection, intervention, and therapy.

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Solubility enhancement of caffeine and furosemide using deep eutectic solvents formed by choline chloride and xylitol, citric acid, sorbitol or glucose

Lomba

Polo

Alejandre

et al. 2023

Journal of Drug Delivery Science and Technology

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Method Development and Application of an Accelerated Solution Stability Screen for Drug Discovery

Cited by 5 publications

References 23 publications

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State

Proteomics mining of cancer hallmarks on a single‐cell resolution

Solubility enhancement of caffeine and furosemide using deep eutectic solvents formed by choline chloride and xylitol, citric acid, sorbitol or glucose

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