Application of albumin-grafted scaffolds to promote neocartilage formation

Lyu, Shaw-Ruey; Kuo, Yung‐Chih; Lin, Min-Hsio; Hsieh, Wen‐Hsin; Chuang, Chia-Wei

doi:10.1016/j.colsurfb.2011.11.019

Cited by 9 publications

(2 citation statements)

References 39 publications

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“…Biological scaffolds or composite materials prepared through the interaction of albumin with other materials are widely used in the field of cartilage tissue [ 25 , 26 ]. Lyu et al modified a polyethylene oxide/chitin/chitosan scaffold with albumin, and through culture experiments with porcine knee chondrocytes, high concentrations of albumin effectively promoted the adhesion, proliferation, and differentiation of this cell, and facilitate the growth and development of chondrocytes, which can be applied in the field of cartilage tissue [ 27 ]. Ferracci et al prepared a photocurable bovine serum albumin methacryloyl (BSA-MA) hydrogel with bovine serum albumin (BSA) and methacrylic anhydride (MAA) as the raw materials, and modified it with carbonate–bicarbonate (CB).…”

Section: Classification Of Natural Biomaterialsmentioning

confidence: 99%

Natural Materials for 3D Printing and Their Applications

Chen

Tian

et al. 2022

Gels

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In recent years, 3D printing has gradually become a well-known new topic and a research hotspot. At the same time, the advent of 3D printing is inseparable from the preparation of bio-ink. Natural materials have the advantages of low toxicity or even non-toxicity, there being abundant raw materials, easy processing and modification, excellent mechanical properties, good biocompatibility, and high cell activity, making them very suitable for the preparation of bio-ink. With the help of 3D printing technology, the prepared materials and scaffolds can be widely used in tissue engineering and other fields. Firstly, we introduce the natural materials and their properties for 3D printing and summarize the physical and chemical properties of these natural materials and their applications in tissue engineering after modification. Secondly, we discuss the modification methods used for 3D printing materials, including physical, chemical, and protein self-assembly methods. We also discuss the method of 3D printing. Then, we summarize the application of natural materials for 3D printing in tissue engineering, skin tissue, cartilage tissue, bone tissue, and vascular tissue. Finally, we also express some views on the research and application of these natural materials.

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Section: Classification Of Natural Biomaterialsmentioning

confidence: 99%

Natural Materials for 3D Printing and Their Applications

Chen

Tian

et al. 2022

Gels

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“…Albumin is also used to treat blood loss, burns, and shock due to its clinically established biocompatibility profile for therapeutic applications [ 38 , 39 ] . Numerous studies have demonstrated that negatively charged groups such as carboxyl, hydroxyl, and sulfonic acid groups on the surface of BSA can induce the chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and promote the adhesion of chondrocytes on the pore surface and the formation of new cartilage [ 40 - 42 ] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of biocompatible BSA-GMA and two-photon polymerization of 3D hydrogels with free radical type I photoinitiator

Li¹,

Liu²,

Guo³

et al. 2023

IJB

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Although the development of three-dimensional (3D) printing technology is growing rapidly in the biomedical field, it remains a challenge to achieve arbitrary 3D structures with high resolution and high efficiency. Protein hydrogels fabricated by two-photon polymerization (TPP) have excellent mechanical properties, high precision, and 3D architecture. However, a large number of the amino acid group in bovine serum albumin (BSA) would be consumed when the protein-based hydrogels use dyes of free radical type II photoinitiators. In this study, we use glycidyl methacrylate (GMA) to modify BSA molecules to obtain a series of BSA-GMA materials, allowing the protein material to be two-photon polymerized with a water-soluble free radical type I photoinitiator. The precisely controllable 3D structure of the BSA-GMA hydrogel was fabricated by adjusting the concentration of the precursor solution, the degree of methacrylation, and the processing parameters of the TPP technique. Importantly, BSA-GMA materials are free of acidic hazardous substances. Meanwhile, the water-soluble initiator lithium phenyl (2,4,6-trimethylbenzoyl) phosphite (LAP) allows TPP on the vinyl group of the GMA chain and thus without consuming its amino acid group. The as-prepared BSA-GMA hydrogel structure exhibits excellent autofluorescence imaging, pH responsiveness, and biocompatibility, which would provide new avenues for potential applications in tissue engineering and biomedical fields to meet specific biological requirements.

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