Application of Advanced Statistics in Ophthalmology

Fan, Qiao; Teo, Yik-Ying; Saw, Seang‐Mei

doi:10.1167/iovs.10-7108

Cited by 137 publications

(101 citation statements)

References 75 publications

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“…As both eyes of some patients were included in this study, a univariate generalized estimating equations model (GEE) was used to adjust for these within-patient inter-eye correlations [16,17]. The GEE model was also used to compare different grades of ONHD and to perform a simple linear regression between different measurements, as well as to compare the age of patients and the damage of GCIPL and RNFL among the groups of ONHD.…”

Section: Statisticsmentioning

confidence: 99%

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Casado

Rebolleda

Guerrero

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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Section: Statisticsmentioning

confidence: 99%

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Casado

Rebolleda

Guerrero

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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“…[27][28][29] However, an analysis of the prevalence of multiple comparison corrections in ophthalmic research and its implications has not been addressed. In this study the prevalence of multiplicity corrections in ophthalmic research is estimated using abstracts at an international research conference.…”

mentioning

confidence: 99%

An Analysis of the Use of Multiple Comparison Corrections in Ophthalmology Research

Stacey

Pouly²,

Czyz³

2012

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. The probability of type I error, or a false-positive result, increases as the number of statistical comparisons in a study increases. Statisticians have developed numerous corrections to account for the multiple comparison problem. This study discusses recent guidelines involving multiple comparison corrections, calculates the prevalence of corrections in ophthalmic research, and estimates the corresponding number of false-positive results reported at a recent international research meeting.METHODS. The 6415 abstracts presented at ARVO 2010 were searched for statistical comparisons (P values) and for use of multiple comparison corrections. Studies that reported five or more P values while reporting no correction factor were used in a simulation study. The simulation study was conducted to estimate the number of false-positive results reported in these studies.RESULTS. Overall, 36% of abstracts reported P values and 1.2% of abstracts used some form of correction. Whereas 8% of abstracts reported at least five P values, only 5% of these used a multiple comparison correction. In these highly statistical studies, simulations resulted in 185 false-positive outcomes found in 30% of abstracts.CONCLUSIONS. The paucity of multiple comparison corrections in ophthalmic research results in inflated type I error and may produce unwarranted shifts in clinical or surgical care. Researchers must make a conscious effort to decide if and when to use a correction factor to ensure the validity of the data. (Invest Ophthalmol Vis Sci.

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“…36 In these models fixed factors were "group" and "position-of-retina". Bonferroni correction was applied for multiple comparisons.…”

Section: Discussionmentioning

confidence: 99%

An exploratory study of temporal integration in the peripheral retina of myopes

Macedo

Encarnação²,

Vilarinho

et al. 2017

Third International Conference on Applications of Optics and Photonics

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The visual system takes time to respond to visual stimuli, neurons need to accumulate information over a time span in order to fire. Visual information perceived by the peripheral retina might be impaired by imperfect peripheral optics leading to myopia development. This study explored the effect of eccentricity, moderate myopia and peripheral refraction in temporal visual integration. Myopes and emmetropes showed similar performance at detecting briefly flashed stimuli in different retinal locations. Our results show evidence that moderate myopes have normal visual integration when refractive errors are corrected with contact lens; however, the tendency to increased temporal integration thresholds observed in myopes deserves further investigation.

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Application of Advanced Statistics in Ophthalmology

Cited by 137 publications

References 75 publications

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

Measurement of retinal nerve fiber layer and macular ganglion cell–inner plexiform layer with spectral-domain optical coherence tomography in patients with optic nerve head drusen

An Analysis of the Use of Multiple Comparison Corrections in Ophthalmology Research

An exploratory study of temporal integration in the peripheral retina of myopes

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