Application of a Nanosensor Based on MWCNT‐Sodium Dodecyl Sulphate Modified Electrode for the Analysis of a Novel Drug, Alpha‐Hydrazinonitroalkene in Human Blood Serum

Abstract

The sensitivity enhancing properties of sodium dodecyl sulphate (SDS) and multi‐walled carbon nanotubes (MWCNTs) were associated to construct a nanosensor based on carbon paste electrode (CPE) by adopting drop cast method. The drop cast method makes use of minimum modifier and the entire modified surface of the sensor is available for the analyte. Surface characterization of the electrodes was carried out using FE‐SEM and EDX. EIS was used for the electrochemical characterization. We report for the first time the electrochemical analysis based on the oxidation of the ‐OH group of a novel drug, alpha‐hydrazinonitroalkene (I) which was found to have antibacterial and antimicrobial properties. The electron transfer kinetic parameters such as the charge transfer coefficient α and heterogeneous rate constant k′ were calculated and they have been found to be 0.64 and 9.62 × 10−2 cm s−1 respectively. The linear response ranges for (I) obtained at this sensor are 1.0 × 10−7 M − 7.0 × 10−7 M and 1.0 × 10−6 M – 4.5 × 10−5 M with a detection limit of (7.03 ± 0.41) × 10−8 M (S/N=3). The interference study suggested that the sensor was free from 1000‐fold excess of UA in the determination of (I). It was important to note that the sensor completely eliminated Ascorbic acid (AA) signal which offered a significant analytical advantage for the determination of the drug at this sensor. The practical usefulness of the modified sensor was demonstrated by the analysis of (I) in blood serum.

Voltammetric Study and Rapid Quantification of Resorcinol in Hair Dye and Biological Samples Using Ultrasensitive Maghemite/MWCNT Modified Carbon Paste Electrode

“…Herein peak potential and half peak potential (E p and E p1/2 ) were substituted and the value of α was determined to be 0.604. Laviron's equation for an adsorption controlled totally irreversible electrochemical process was defined by : …”

A Simple and Highly Selective Determination of Telmisartan at Sodium Dodecyl Sulfate Modified Pyrolytic Graphite Surface

“…In the presence of the SDS at Pt electrode, the charge transfer resistance has also found to be lower as compared to bare earlier . The presence of SDS surfactant showed the better homogeneity for sample preparation and provided better contact at glassy carbon electrode (GCE), while in the case of the carbon paste electrode (CPE) the smooth surface with bundles like structures was obtained .…”

“…To eliminate adsorption complications, the electrode was dipped in a solution of 10 mM sodium dodecyl sulfate (SDS), an anionic surfactant. It is generally used to overcome adsorption and to improve the sensor/solution interface in electroanalysis, which increases the rate of electron transfer between the sensor surface and electro‐active substances .…”

A Sensing Platform Using Ag/Pt Core‐shell Nanostructures Supported on Multiwalled Carbon Nanotubes to Detect Hydroxyurea

“…Moreover, their high porosity supplies numerous electrochemical active sites that amend their redox events [27,28]. These kinds of electrodes have been used for the designation of many organic and biological molecules [29][30][31][32][33][34][35]. In electrocatalytic studies, the use of CNTs boosts the mass transport and electron-transfer kinetics [36,37].…”