A Sensing Platform Using Ag/Pt Core‐shell Nanostructures Supported on Multiwalled Carbon Nanotubes to Detect Hydroxyurea

Abstract

Developing anticancer sensing platforms has a significant impact on individual cancer treatment. Monitoring of anticancer drugs in bodily fluid allows doctors to prescript the efficient amount of drugs that significantly lower chemotherapy side effects on individuals. In this study, for the first time, we explored a chemically modified carbon paste electrode (CPE), containing 2, 2'-(1, 6-hexanediylbisnitrilo-ethylidine)-bis-hydroquinone (HEH) and Ag@Pt/multiwalled carbon nanotubes (MWCNTs), to monitor hydroxyurea (HU), a highly toxic anticancer drug, in human serum. The electrochemical study was carried out to determine the electrocatalytic rate constant, the diffusion coefficient, and the electrontransfer coefficient of HU oxidation. The DPV of HU showed three linear dynamic ranges in the concentration ranges of 0.05 to 1.0 μM, 1.0 to 50.0, and 50.0 to 1000.0 μM. The detection limit was lowered to 23.0 nM. With this sensing platform, DPV peaks of mixed HU and uric acid (UA) could be isolated from each other, indicating satisfied selectivity. The proposed electrochemical sensor serves as a handy device for monitoring of HU in clinical samples.

Highly Efficient Enzyme-Free Glutamate Sensors Using Porous Network Metal–Organic Framework-Ni-NiO-Ni-Carbon Nanocomposites

“…The catalytic oxidation of Glu at the PNM-NiO-Ni-Carbon/GCE electrode was investigated using the chronoamperometry method, as depicted in Figure 4A. The diffusion coefficient (D) for Glu was determined as 1.38 × 10 −4 cm 2 /s using the Cottrell equation, 39 based on the resulting slopes from Figure 4B plotted against the Glu concentration (Figure 4C). Moreover, the catalytic rate constant (k h ) for the reaction between Glu and the PNM-NiO-Ni-Carbon/GCE was determined as 54.85 (M s) −1 through the Galus method, 40 by analyzing the slope of I C /I L vs t 1/2 (Figure 4D).…”

Electrochemical neuron-specific enolase (NSE) immunosensor based on CoFe2O4@Ag nanocomposite and AuNPs@MoS2/rGO

“…S1C, the absorption spectrum of CoFe 2 O 4 @Ag nanocomposite was different from that of CoFe 2 O 4 owing to the incorporation of silver nanoparticles into nanocomposite. There was no obvious absorption band on UVeVis spectrum of CoFe 2 O 4 whereas the absorption band at about 425e431 nm was observed, indicating the presence of silver nanoparticles [46]. SEM images were obtained for the investigation of surface morphology and particle size features of CoFe 2 O 4 @Ag nanocomposite and CoFe 2 O 4 .…”

Metal oxide‐based gas sensors for the detection of exhaled breath markers

“…The integration of Pt nanomaterials into a sensing platform has been widely reported owing to the high catalytic activity of these nanoparticles in the redox process that enhances sensing characteristics (Cho et al, 2017;Haghshenas et al, 2020). Notably, the were modified with Pt nanoparticles using apoferritin (Kim et al, 2017;Kim, Choi, et al, 2016).…”

“…Reduced graphene oxide, as a two-dimensional nanostructure, with excellent surface-to-volume ratio, low toxicity and outstanding electron mobility (200,000 cm 2 V −1 S −1 ), has been widely utilized for disease monitoring (Feng et al, 2017;Lee et al, 2018;Vajhadin et al, 2020;Zhang et al, 2018). In addition to graphene, other twodimensional materials such as 2D-SnSe 2 and Ti 3 C 2 MXene have employed for producing flexible MGS owing to lightweight, outstanding flexibility and low cost (Sun et al, 2020;Tannarana et al, 2020).…”

“…The integration of Pt nanomaterials into a sensing platform has been widely reported owing to the high catalytic activity of these nanoparticles in the redox process that enhances sensing characteristics (Cho et al, 2017; Haghshenas et al, 2020). Notably, the methodology for the incorporation of nanomaterial into ZnO plays a significant role in ensuring its catalytic activity in the absence of agglomeration.…”