Application of a Microcomputer-Based System to Control and Monitor Bacterial Growth

Titus, Jeffrey A.; Luli, G W; Dekleva, Michael L.; Strohl, William R.

doi:10.1128/aem.47.2.239-244.1984

Cited by 10 publications

(2 citation statements)

References 8 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The temperature was maintained at 37°C by circulating water through internal baffles of the fermentor by means of a Lauda RM6 circulating water bath. An Apple Ile computer equipped with a Cyborg ISAAC 91A data acquisition system was used for computer control as described elsewhere (25,29).…”

Section: Methodsmentioning

confidence: 99%

Glucose-stat, a glucose-controlled continuous culture

Kleman

Chalmers

Luli

et al. 1991

Appl Environ Microbiol

View full text Add to dashboard Cite

A predictive and feedback proportional control algorithm, developed for fed-batch fermentations and described in a companion paper (G. L. Kleman, J. J. Chalmers, G. W. Luli, and W. R. Strohl, Appl. Environ. Microbiol. 57:910-917, 1991), was used in this work to control a continuous culture on the basis of the soluble-glucose concentration (called the glucose-stat). This glucose-controlled continuous-culture system was found to reach and maintain steady state for 11 to 24 residence times when four different background glucose concentrations (0.27, 0.50, 0.7, and 1.5 g/liter) were used. The predictive-plus-feedback control system yielded very tight control of the continuous nutristat cultures; glucose concentrations were maintained at the set points with less than 0.003 standard error. Acetate production by Escherichia coli B in glucose-stats was found not to be correlated with the level of steady-state soluble-glucose concentration.

show abstract

Section: Methodsmentioning

confidence: 99%

Glucose-stat, a glucose-controlled continuous culture

Kleman

Chalmers

Luli

et al. 1991

Appl Environ Microbiol

View full text Add to dashboard Cite

show abstract

“…Strohl/Ohio State 1984 Titus et al (1984) Descriptions and summaries of early academic and industrial non-control computer applications in off-line simulations, data acquisition/analysis, and optimization are available (Alford, 1978;Blanch and Rogers, 1971;Bošnjak et al, 1978;Constantinides and Shao, 1981;Halme et al, 1978;Hampel et al, 1976;Heijnen et al, 1979;Kishimoto et al, 1980;Lim and Lee, 1991;Nyiri, 1972;Okabe and Aiba, 1975;Shimizu, 1993;Weigand, 1978). R.P.…”

Section: Vibrio Matriegens Bacillus Thuringensismentioning

confidence: 99%

Bioprocess monitoring and computer control: Key roots of the current PAT initiative

Junker

Wang

2006

Biotech & Bioengineering

113

View full text Add to dashboard Cite

This review article has been written for the journal, Biotechnology and Bioengineering, to commemorate the 70th birthday of Daniel I.C. Wang, who served as doctoral thesis advisor to each of the co-authors, but a decade apart. Key roots of the current PAT initiative in bioprocess monitoring and control are described, focusing on the impact of Danny Wang's research as a professor at MIT. The history of computer control and monitoring in biochemical processing has been used to identify the areas that have already benefited and those that are most likely to benefit in the future from PAT applications. Past applications have included the use of indirect estimation methods for cell density, expansion of on-line/at-line and on-line/in situ measurement techniques, and development of models and expert systems for control and optimization. Future applications are likely to encompass additional novel measurement technologies, measurements for multi-scale and disposable bioreactors, real time batch release, and more efficient data utilization to achieve process validation and continuous improvement goals. Dan Wang's substantial contributions in this arena have been one key factor in steering the PAT initiative towards realistic and attainable industrial applications.

show abstract