Application of a liquid chromatography tandem mass spectrometry method to the analysis of water-soluble vitamins in Italian pasta

Leporati, Andrea; Catellani, Dante; Suman, Michele; Andreoli, Roberta; Manini, Paola; Niessen, W.M.A.

doi:10.1016/j.aca.2004.10.006

Cited by 90 publications

(69 citation statements)

References 10 publications

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“…Comparing the obtained LOD and LOQ values with the literature, it can be noticed that in the works which present the application of the same detector, the LOD and LOQ values are slightly lower or comparable (Ghorbani et al 2004;Vidović et al 2008;Leporatia et al 2005). However, these chromatographic systems do not allow the simultaneous determination of such number of analytes.…”

Section: Resultsmentioning

confidence: 55%

Multivitamin Analysis of Fruits, Fruit–Vegetable Juices, and Diet Supplements

2012

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Vitamins are organic compounds that are required for various biological functions. In general, vitamins are not synthesized in the human body, but lack or deficiency of them may lead to certain diseases. Determinations of 11 vitamins in various products were performed, which included ascorbic acid (C), seven vitamins of the B group (thiamine B 1 , riboflavin B 2 , nicotinamide B 3 , pantothenic acid B 5 , pyridoxine B 6 , folic acid B 9 , and cyanocobalamin B 12 ), as well as three fat-soluble vitamins (retinol A, cholecalciferol D 3 , and α-tocopherol E). A column with RP18 stationary phase and a diode array detector with properly selected analytical wavelengths for each compound were used. A gradient of trifluoroacetic acid in water with methanol was used as the mobile phase. Limits of quantification in the range of 0.70-2.90 μg/mL for watersoluble vitamins and 1.85-15.84 μg/mL for fat-soluble vitamins were obtained. Those values are sufficient for determinations of the aforementioned compounds in foodstuff. The developed procedure of sample preparation together with chromatographic system can be used for food quality monitoring in the food industry.

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Section: Resultsmentioning

confidence: 55%

Multivitamin Analysis of Fruits, Fruit–Vegetable Juices, and Diet Supplements

2012

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“…In recent years, several methods for the determination of FA have been reported, including high-performance liquid chromatography (HPLC), [4][5][6][7][8][9] chemiluminescence (CL), [10][11][12] spectrophotometric, 13,14 electroanalytical, [15][16][17] and fluorometric methods. 18,19 However, HPLC technique has superiority in terms of separating and quantifying different forms of FA with the minimum interference from enzymes but it involves complicated system operation and maintenance, high consumption of samples and expensive reagents.…”

Section: 2mentioning

confidence: 99%

Europium-Enoxacin Complex as Fluorescence Probe for the Determination of Folic Acid in Pharmaceutical and Biological Samples

Alam¹,

Kamruzzaman²,

Lee³

et al. 2012

Bulletin of the Korean Chemical Society

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A simple, rapid and sensitive spectrofluorometric method was developed for the determination of folic acid (FA), based on its quenching effect on the fluorescence intensity of enoxacin (ENX)-europium (Eu 3+) complex as a fluorescent probe. Fluorometric interaction between ENX-Eu 3+ complex and FA was studied using UVvisible and fluorescence spectroscopy. The quenched fluorescence intensity at an emission wavelength of 614 nm was proportional to the concentration of FA. Optimum conditions for the determination of FA were investigated. Under optimal conditions, the reduced fluorescence intensity at 614 nm was responded linearly with the concentration of FA. The linearity was maintained in the range of 1.25 × 10 −9 to 1.50 × 10 −7 M (R = 0.9986) with the limit of detection (3S b /m) (where S b is the standard deviation of blank and m is the slop of linear calibration curve) of 6.94 × 10 −10 M. The relative standard deviation (RSD) for 9 repeated measurements of 1.0 × 10 −9 M FA was 1.42%. This method was simple, cost effective, and relatively free of interference from coexisting substances. Successful determinations of FA in pharmaceutical formulation and biological samples with the developed method were demonstrated.

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“…It can be inferred that PCA might be the degradation intermediate in PMS/Co(II) system and it also acts an energy acceptor and sensitizes the CL emission. PCA and other intermediates were oxidized to inorganic compound by the radicals, such as SO 5 of PGA were decreased to blank [29]. The chemiluminescence mechanism of PGA in the PMS/Co(II) system can be summarized as the following reactions:…”

Section: The Chemiluminescence Mechanism Of Pga In the Pms/co(ii) Systemmentioning

confidence: 99%

“…Although microbiological assay is the most commonly used method, it is time consuming, needs great care and skill [4]. Chromatographic methods have the advantage of separating and quantifying different forms of folic acid and its derivations and minimum interference from enzymes but involve set up cost, a complex extraction, and purification procedure [5,6]. Enzyme protein binding assay is much cheaper, rapider, and easier but there exits considerable variation between different kits and self-life of kits is very short [7].…”

Section: Introductionmentioning

confidence: 99%

Determination of folic acid by chemiluminescence based on peroxomonosulfate-cobalt(II) system

Zhang

Zhao

Lin

2008

Talanta

119

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Based on the chemiluminescence (CL) phenomena of folic acid in peroxomonosulfate-cobalt(II) system, a rapid and sensitive CL method was developed for determination of folic acid in pharmaceutical preparations and its urinary metabolism processes. Under the optimum conditions, the relative CL intensity was linear over the concentration ranging from 10 −9 to 8 × 10 −7 mol L −1 (R 2 = 0.9991) with a detection limit as low as 6 × 10 −10 mol L −1 (S/N = 3) and relative standard deviation was 2.63% for 2 × 10 −8 mol L −1 folic acid (n = 11). This method has been successfully applied to the determination of folic acid in tablets and human urine. The blank CL emission was yielded owing to the formation of singlet oxygen molecular pair from the quenching experiment of 1,4-diazabicyclo[2.2.2]octane, and pterine-6-carboxylic acid might be the degradation intermediate in this system and it also acts an energy acceptor and sensitizes the chemiluminescence based on the studies of the CL and fluorescence spectra.

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Application of a liquid chromatography tandem mass spectrometry method to the analysis of water-soluble vitamins in Italian pasta

Cited by 90 publications

References 10 publications

Multivitamin Analysis of Fruits, Fruit–Vegetable Juices, and Diet Supplements

Multivitamin Analysis of Fruits, Fruit–Vegetable Juices, and Diet Supplements

Europium-Enoxacin Complex as Fluorescence Probe for the Determination of Folic Acid in Pharmaceutical and Biological Samples

Determination of folic acid by chemiluminescence based on peroxomonosulfate-cobalt(II) system

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