Application of a hexapole collision and reaction cell in ICP-MS Part II: Analytical figures of merit and first applications

Feldmann, Ingo; Jakubowski, Norbert; Thomas, Christoph; Stuewer, Dietmar

doi:10.1007/s002160051634

Cited by 103 publications

(103 citation statements)

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“…Furthermore, interferences of singly-charged with doublycharged atomic ions (e.g., 91 Zr 1 and 182 W 21 , m/Dm # 1 330) and with molecular ions have been observed in mass spectra (e.g., 80 Se 1 and…”

Section: Limits For Precision and Accuracy Of Isotope Ratio Measuremementioning

confidence: 99%

“…In this experiment, a special solution introduction system for introducing elemental iodine via the gas phase in ICP was applied. 36 The accuracy of 129 I determination was investigated by Kerl et al 36 21 , which can be reduced using a hydride generator for solution introduction. Whereas the detection limit of 79 Se in sector field ICP-MS was 100 pg mL 21 by applying hydride generation, 37 in quadrupole ICP-MS with a hexapole collision cell the detection limit could be reduced to 5 pg mL 21 , because the disturbing argon hydride molecular ions, 38 Pu at ultratrace levels play an important role.…”

Section: Capability Of Icp-ms With a Collision Cellmentioning

confidence: 99%

“…36 The accuracy of 129 I determination was investigated by Kerl et al 36 21 , which can be reduced using a hydride generator for solution introduction. Whereas the detection limit of 79 Se in sector field ICP-MS was 100 pg mL 21 by applying hydride generation, 37 in quadrupole ICP-MS with a hexapole collision cell the detection limit could be reduced to 5 pg mL 21 , because the disturbing argon hydride molecular ions, 38 Pu at ultratrace levels play an important role. Therefore the application of a solution introduction system with a desolvator (e.g., the microconcentric nebulizer, Aridus, from CETAC) is advantageous for ultrasensitive determination of 236 U and 239 Pu, or an alternative collision gas (for example oxygen) is helpful for 129 I determination.…”

Section: Capability Of Icp-ms With a Collision Cellmentioning

confidence: 99%

“…Meinhard Associates, Inc., Santa Ana, USA), and the Aridus, in comparison to the ultrasonic nebulizer (USN with desolvator both from CETAC Technologies, Omaha, USA) are summarized in Table 10. The highest sensitivity was observed using the USN and the best overall detection efficiency for the DIHEN at a low solution uptake rate of 10 mL min 21 . Radioactive waste solutions were analyzed, for example, using the DIHEN (which works without a spray chamber and does not produce waste solution) at a solution uptake rate of down to 1 mL min 21 by ICP-SFMS.…”

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confidence: 98%

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State-of-the-art and progress in precise and accurate isotope ratio measurements by ICP-MS and LA-ICP-MS : Plenary Lecture

Becker

2002

J. Anal. At. Spectrom.

146

123

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The capability to determine isotope abundances is a main feature of mass spectrometry. The precise and accurate determination of isotope ratios is required for different application fields, such as: isotope ratio measurements of stable isotopes in nature, especially for the investigation of isotope variation in nature or age dating; determining isotope ratios of radiogenic elements in the nuclear industry; quality assurance of fuel material for reprocessing plants, nuclear material accounting and radioactive waste control; and tracer experiments using highly enriched stable isotopes or long-lived radionuclides in biological or medical studies. Inductively coupled plasma mass spectrometry and laser ablation ICP-MS (LA-ICP-MS) provides excellent sensitivity, precision and good accuracy for isotope ratio measurements with practically no restriction with respect to the ionization potential of the element investigated. Therefore both ICP-MS and LA-ICP-MS are increasingly replacing thermal ionization mass spectrometry (TIMS), which has been used as the dominant analytical technique for precise isotope ratio measurements for many decades. In the last few years instrumental progress for improving figures of merit in isotope ratio measurements in ICP-MS and LA-ICP-MS with a single ion detector has been achieved by the introduction of the collision cell interface, in order to dissociate disturbing argon-based molecular ions, to reduce the kinetic energy of ions and neutralize the disturbing argon ions of the plasma gas (Ar 1 ). The application of the collision cell in ICP-MS results in higher ion transmission, improved sensitivity and better precision of isotope ratio measurements compared to ICP-MS without the collision cell. The most important instrumental improvement for isotope analysis by sector field ICP-MS was the application of a multiple ion collector device (MC-ICP-MS) (developed about 10 years ago) in order to obtain better precision of isotope ratio measurements of up to 0.002%, RSD.

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Section: Limits For Precision and Accuracy Of Isotope Ratio Measuremementioning

confidence: 99%

Section: Capability Of Icp-ms With a Collision Cellmentioning

confidence: 99%

Section: Capability Of Icp-ms With a Collision Cellmentioning

confidence: 99%

mentioning

confidence: 98%

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State-of-the-art and progress in precise and accurate isotope ratio measurements by ICP-MS and LA-ICP-MS : Plenary Lecture

Becker

2002

J. Anal. At. Spectrom.

146

123

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“…These interferences can be overcome by choosing an interference free isotope, removing the matrix (Evans & Giglio, 1993), using alternative sample introduction systems (Evans & Giglio, 1993), using mathematical corrections equations (Dams, Goossens, & Moens, 1995), employing cool plasma conditions (Vanhaecke et al, 2000), using a collision or reaction cell (Feldmann et al, 1999), or by using a high resolution mass analyzer (Nonose & Kubota, 2001). Elements with high masses, such as Pt, are less susceptible to molecular interferences than lower masses, such as Ru (Hsiung et al, 1997;Brouwers et al, 2007c).…”

Section: B Interferencesmentioning

confidence: 99%

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

Brouwers

Tibben

Rosing

et al. 2008

Mass Spectrometry Reviews

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Metal-based anticancer agents are frequently used in the treatment of a wide variety of cancer types. The monitoring of these anticancer agents in biological samples is important to understand their pharmacokinetics, pharmacodynamics, and metabolism. In addition, determination of metals originating from anticancer agents is relevant to assess occupational exposure of health care personnel working with these drugs. The high sensitivity of inductively coupled plasma mass spectrometry (ICP-MS) has resulted in an increased popularity of this technique for the analysis of metal-based anticancer drugs. In addition to the quantitative analysis of the metal of interest in a sample, ICP-MS can be used as an ultrasensitive metal selective detector in combination with speciation techniques such as liquid chromatography. In the current review we provide a systematic survey of publications describing the analysis of platinum-and ruthenium-containing anticancer agents using ICP-MS, focused on the determination of total metal concentrations and on the speciation of metal compounds in biological fluids, DNA-and protein-adducts, and environmental samples. We conclude that ICP-MS is a powerful tool for the quantitative analysis of metal-based anticancer agents from multiple sample sources.

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Atomic Spectrometric Techniques for the Analysis of Clinical Samples

Bermejo-Barrera

Moreda-Piñeiro

Alonso

2012

Analytical Techniques for Clinical Chemistry

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Application of a hexapole collision and reaction cell in ICP-MS Part II: Analytical figures of merit and first applications

Cited by 103 publications

References 0 publications

State-of-the-art and progress in precise and accurate isotope ratio measurements by ICP-MS and LA-ICP-MS : Plenary Lecture

State-of-the-art and progress in precise and accurate isotope ratio measurements by ICP-MS and LA-ICP-MS : Plenary Lecture

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

Atomic Spectrometric Techniques for the Analysis of Clinical Samples

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