Application of a Cold Patch for Relieving Pain after Transepithelial Photorefractive Keratectomy

Zeng, Yuan; Yi, Li; Gao, Jianhua

doi:10.1155/2015/850245

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…In our collective clinical experience, use of an ice or cold pack can be very effective in relieving the pain associated with corneal abrasion or following procedures such as PRK and corneal collagen cross-linking. This is supported by results from a randomised controlled trial by Zeng et al 15 In this study, the simple application of a cold patch was found to be effective in reducing pain on a visual analogue scale as well as significantly reducing the use of LA drops and non-opioid oral analgesia following PRK.…”

Section: Alternative Options For Analgesia In Patients With Corneal Painsupporting

confidence: 63%

Topical anaesthetic in the treatment of corneal epithelial defects: What are the risks?

Fraser

Walland²,

Chan

et al. 2019

Aust J Gen Pract

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Section: Alternative Options For Analgesia In Patients With Corneal Painsupporting

confidence: 63%

Topical anaesthetic in the treatment of corneal epithelial defects: What are the risks?

Fraser

Walland²,

Chan

et al. 2019

Aust J Gen Pract

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“…Irrigating the ocular surface with chilled saline may be uncomfortable or even painful for the patient (Neuffer et al., 2013). Cold compresses using ice packs can be difficult to use, especially in the disabled or elderly populations, as movement is limited and frostbite is possible if not correctly used (Zeng et al., 2015). A recent report concluded that cryotherapy provides efficient and efficacious mitigation for IVI‐related pain (Chandrasekaran et al., 2023).…”

Section: Discussionmentioning

confidence: 99%

Pain control and subconjunctival haemorrhage after intravitreal injection using cooled anaesthetic eyedrops and antiseptics: A prospective, double‐blind, randomized controlled trial

Moshkovsky,

Golan,

Aviel Gadot

et al. 2023

Acta Ophthalmologica

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PurposeTo evaluate whether cooled anaesthetic eyedrops and antiseptics alleviate pain and minimise subconjunctival haemorrhage following intravitreal injection.MethodsA prospective, double‐masked, randomised controlled trial of 100 participants receiving either cooled (n = 50) or room temperature (n = 50) topical anaesthetic eyedrops and antiseptics before receiving an injection of bevacizumab. Baseline tolerability was estimated using a self‐reported pain sensitivity questionnaire.ResultsOverall tolerability was comparable between the study group and the control group (0.75 ± 0.13 vs. 0.74 ± 0.14, respectively, p = 0.99). Subconjunctival haemorrhage incidence was similar in both groups (80% vs. 86%, respectively, p = 0.113), as was subconjunctival haemorrhage size (2.75 ± 5.51 mm2 vs. 5.53 ± 10.72 mm2, respectively, p = 0.11). Sub‐group analysis demonstrated that the participants taking daily ocular eyedrops who received cooled anaesthetic eyedrops and antiseptics reported less pain at 10 min and less burning sensation at 24 h compared with matched controls (0.67 ± 1.50 vs. 2.50 ± 3.03, respectively, p = 0.040 and 0.00 ± 0.00 vs. 1.44 ± 2.96, respectively, p = 0.045). Participants who received cooled eyedrops and did not use antithrombotic therapy had smaller‐sized subconjunctival haemorrhages compared with matched controls (1.55 ± 1.87 mm2 vs. 8.29 ± 14.61 mm2, respectively, p = 0.038). Participants with hypertension who received cooled eyedrops had smaller‐sized subconjunctival haemorrhage compared with matched controls (2.33 ± 4.99 mm2 vs. 6.89 ± 12.41 mm2, respectively, p = 0.045).ConclusionThe benefit of using cooled anaesthetic eyedrops and antiseptics to alleviate pain and minimise subconjunctival haemorrhage following intravitreal injection was not proven in the general population. It may be beneficial in part for some patients, such as those who regularly use eyedrops, patients with hypertension or those not on antithrombotic therapy.

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“…For example, application of a cold pack to the eye for 24 hours after PRK was associated with decreased pain scores at 8 hours, 16 hours, and 24 hours, in addition to decrease in use of pain medication. 52 It should be noted that application of cold packs is associated with ocular physiologic changes, which, in particular, may adversely affect certain patient populations (eg, angle-closure glaucoma). 53…”

Section: Emerging and New Therapeuticsmentioning

confidence: 99%

Topical analgesics for acute corneal pain: current options and emerging therapeutics

Lafreniere

Szczesniak

Courtney

et al. 2023

J Cataract Refract Surg

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Acute corneal pain is a common complaint that causes significant distress to patients and continues to challenge therapeutic avenues for pain management. Current topical treatment options have marked limitations in terms of both efficacy and safety, thus often prompting the adjunctive use of systemic analgesics, including opioids. In general, there have not been extensive advancements in pharmacologic options for the management of corneal pain over the past several decades. Despite this, multiple promising therapeutic avenues exist which hold the potential to transform the ocular pain landscape, including druggable targets within the endocannabinoid system. This review will summarize the current evidence base for topical nonsteroidal anti-inflammatory drugs, anticholinergic agents, and anesthetics before focusing on several potential avenues in the setting of acute corneal pain management, including autologous tear serum, topical opioids and endocannabinoid system modulators.

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Application of a Cold Patch for Relieving Pain after Transepithelial Photorefractive Keratectomy

Cited by 13 publications

References 24 publications

Topical anaesthetic in the treatment of corneal epithelial defects: What are the risks?

Topical anaesthetic in the treatment of corneal epithelial defects: What are the risks?

Pain control and subconjunctival haemorrhage after intravitreal injection using cooled anaesthetic eyedrops and antiseptics: A prospective, double‐blind, randomized controlled trial

Topical analgesics for acute corneal pain: current options and emerging therapeutics

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