Application of a buprenorphine transdermal patch for the perioperative analgesia in patients who underwent simple lumbar discectomy

Abstract

This study aimed to investigate the perioperative analgesic effect of a buprenorphine transdermal patch in patients who underwent simple lumbar discectomy.In total, 96 patients were randomly divided into parecoxib intravenous injection (Group A), oral celecoxib (Group B), and buprenorphine transdermal patch groups (Group C). The pain status, degree of satisfaction, adverse effects, and condition in which the patient received tramadol hydrochloride for uncontrolled pain were recorded on the night before surgery, postoperative day 1, postoperative day 3, and postoperative day 5.The degree of patient satisfaction in Group C was higher than that in Groups A and B, with minimal adverse effects.The buprenorphine transdermal patch had a better perioperative analgesic effect in patients who underwent simple lumbar discectomy.

Transdermal buprenorphine for acute postoperative pain: a systematic review

“…Surgical procedures included spine surgery, 17 , 19 , 22 major 15 and elective 18 abdominal surgery, hysterectomy and myomectomy, 20 , 21 hip surgery, 16 and hallux valgus 23 corrections. Transdermal buprenorphine was started 6 to 48 hours before surgery in doses ranging from 5 mcg h −1 to 52.5 mcg h −1 15 , 16 , 17 , 18 , 22 , 23 and maintained for 1–7 days after the procedure. Only one study initiated transdermal buprenorphine 36 hours after surgery and maintained it for 28 days after the procedure.…”

“… 17 Control groups received placebo, 18 , 19 , 20 tramadol, 16 , 17 a different dosage of transdermal buprenorphine. 18 , 20 , 21 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) 22 , 23 or transdermal fentanyl. 15 The risk of bias summary for included studies is shown in Fig.…”

“…In six studies, buprenorphine was considered more effective than placebo, 18 , 19 , 20 celecoxib 22 , 23 and tramadol 16 for reducing postoperative pain scores. In three studies, buprenorphine was considered as effective as tramadol, 17 parecoxib 22 and flurbiprofen 23 for reducing postoperative pain scores. In one study, buprenorphine led to higher VAS scores than transdermal fentanyl.…”

“… 5 , 6 , 9 Such a route has been used for the treatment of chronic pain conditions, 9 , 10 , 12 with some recent studies investigating the use of perioperative transdermal buprenorphine for the treatment of postoperative pain. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 …”

Perioperative analgesia with a buprenorphine transdermal patch for hallux valgus surgery: a prospective, randomized, controlled study

“…This approach avoids oral and intravenous drugs and provides psychological comfort to the patients. 25 Specifically for the patients presenting comorbid conditions and polypharmacy complications, the extended analgesia duration offered by the BTDS allowed less frequent dosing, which may help improve patient acceptability.…”