Application of 3D Printing in Implantable Medical Devices

Wang, Zhenzhen; Yang, Young-Soo

doi:10.1155/2021/6653967

Cited by 37 publications

(30 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Implantable devices can be prepared using a wide variety of techniques, including hot-melt extrusion, injection molding, and 3D-printing (A. S. Stewart et al., 2018 ; Domsta & Seidlitz, 2021 ; Z. Wang & Yang, 2021 ). The use of 3D-printing technologies has been widely explored for the manufacture of a wide range of drug delivery systems such as implantable devices, oral dosage forms, or suppositories (Mathew et al., 2019 ; Awad et al., 2020 ; Domínguez-Robles et al., 2020 ; Melocchi et al., 2020 ; S. Stewart et al., 2020 ; S. A. Stewart et al., 2020 ; Borandeh et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs

et al. 2022

View full text Add to dashboard Cite

Implantable drug delivery systems offer an alternative for the treatments of long-term conditions (i.e. schizophrenia, HIV, or Parkinson’s disease among many others). The objective of the present work was to formulate implantable devices loaded with the model hydrophobic drug olanzapine (OLZ) using robocasting 3D-printing combined with a pre-formed rate controlling membrane. OLZ was selected as a model molecule due to its hydrophobic nature and because is a good example of a molecule used to treat a chronic condition schizophrenia. The resulting implants consisted of a poly(ethylene oxide) (PEO) implant coated with a poly(caprolactone) (PCL)-based membrane. The implants were loaded with 50 and 80% (w/w) of OLZ. They were prepared using an extrusion-based 3D-printer from aqueous pastes containing 36–38% (w/w) of water. The printing process was carried out at room temperature. The resulting implants were characterized by using infrared spectroscopy, scanning electron microscopy, thermal analysis, and X-ray diffraction. Crystals of OLZ were present in the implant after the printing process. In vitro release studies showed that implants containing 50% and 80% (w/w) of OLZ were capable of providing drug release for up to 190 days. On the other hand, implants containing 80% (w/w) of OLZ presented a slower release kinetics. After 190 days, total drug release was ca. 77% and ca. 64% for implants containing 50% and 80% (w/w) of OLZ, respectively. The higher PEO content within implants containing 50% (w/w) of OLZ allows a faster release as this polymer acts as a co-solvent of the drug.

show abstract

Section: Introductionmentioning

confidence: 99%

3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Not unlike traditional implants, which have been used in orthopedic surgery for decades, these 3D-printed implants are manufactured in titanium using a powder-based Electron Beam Melting (EBM) 3D printer [ 65 , 67 , 68 , 69 ]. In addition, there are currently efforts underway to further the research in the use of artificial bone [ 70 , 71 ] and soft tissue [ 71 , 72 , 73 ]. However, a detailed discussion of this topic is beyond the scope of this paper.…”

Section: Discipline Specific Applicationsmentioning

confidence: 99%

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

Meyer-Szary

Luis

Mikulski

et al. 2022

IJERPH

View full text Add to dashboard Cite

Medicine is a rapidly-evolving discipline, with progress picking up pace with each passing decade. This constant evolution results in the introduction of new tools and methods, which in turn occasionally leads to paradigm shifts across the affected medical fields. The following review attempts to showcase how 3D printing has begun to reshape and improve processes across various medical specialties and where it has the potential to make a significant impact. The current state-of-the-art, as well as real-life clinical applications of 3D printing, are reflected in the perspectives of specialists practicing in the selected disciplines, with a focus on pre-procedural planning, simulation (rehearsal) of non-routine procedures, and on medical education and training. A review of the latest multidisciplinary literature on the subject offers a general summary of the advances enabled by 3D printing. Numerous advantages and applications were found, such as gaining better insight into patient-specific anatomy, better pre-operative planning, mock simulated surgeries, simulation-based training and education, development of surgical guides and other tools, patient-specific implants, bioprinted organs or structures, and counseling of patients. It was evident that pre-procedural planning and rehearsing of unusual or difficult procedures and training of medical professionals in these procedures are extremely useful and transformative.

show abstract

“…In regenerative medicine, scaffolds are essential for cell growth and could provide a three-dimensional structure for cell differentiation and migration to restore the normal function of damaged organs (Khodakaram-Tafti et al, 2017). The preparation of scaffolds can be accomplished with various source materials, including decellularizing tissue (Hashemi et al, 2018), 3D printing technologies (Wang and Yang, 2021), tailored hydrogels (Slaughter et al, 2009), and electrospinning (Malik et al, 2021). Recent studies have used biological scaffolds comprising 3D graphene and artificial photonic crystals for stem cell culture.…”

Section: Treatment Of New Materials In Sensorineural Hearing Lossmentioning

confidence: 99%

Application of New Materials in Auditory Disease Treatment

Cai

et al. 2022

Front. Cell. Neurosci.

View full text Add to dashboard Cite

Auditory diseases are disabling public health problems that afflict a significant number of people worldwide, and they remain largely incurable until now. Driven by continuous innovation in the fields of chemistry, physics, and materials science, novel materials that can be applied to hearing diseases are constantly emerging. In contrast to conventional materials, new materials are easily accessible, inexpensive, non-invasive, with better acoustic therapy effects and weaker immune rejection after implantation. When new materials are used to treat auditory diseases, the wound healing, infection prevention, disease recurrence, hair cell regeneration, functional recovery, and other aspects have been significantly improved. Despite these advances, clinical success has been limited, largely due to issues regarding a lack of effectiveness and safety. With ever-developing scientific research, more novel materials will be facilitated into clinical use in the future.

show abstract

Application of 3D Printing in Implantable Medical Devices

Cited by 37 publications

References 65 publications

3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs

3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

Application of New Materials in Auditory Disease Treatment

Contact Info

Product

Resources

About