Application of 3d Printing in Innovated Drug Delivery: A Review

Abstract

Increasing requests for modified and personalized pharmaceutics and medical materials makes the implementation of additive manufacturing increased rapidly in recent years. 3D printing has been involved numerous advantages in case of reduction in waste, flexibility in the design, and minimizing the high cost of intended products for bulk production of. Several of 3D printing technologies have been developed to fabricate novel solid dosage forms, including selective laser sintering, binder deposition, stereolithography, inkjet printing, extrusion-based printing, and fused deposition modeling. The selection of 3D printing techniques depends on their compatibility with the printed drug products. This review intent to provide a perspective on the incentives and possible applications of 3D printed pharmaceuticals, besides a practical viewpoint on how 3D printing could be included across the pharmaceutical field.

3D printing technology in pharmaceutical science

“…A formation like poly hydrochloric has been tougher than just the polyacrylonitrile (pan substance softens projects 180-220°c which would be relatively low just as polyacrylonitrile (pan. Polyamide melting point seems to be between 10 min -67 percent ° 3 °, consequently polylactide along with polyacrylonitrile (pan might be some better choices for any one of the installations [6].…”

An overview of poly(vinyl alcohol) and poly(vinyl pyrrolidone) in pharmaceutical additive manufacturing

“…These findings should not be shocking because the bulk of pharmaceutical drugs are mass produced in a few distinct strengths based on the dosage necessary to generate their therapeutic effect in the majority of patients, according to the so-called one-size-fits-all approach. [4,5] In this way, the administered dose could be below or above the optimum drug concentration for individual patients, resulting in toxicity, adverse effects, or minimal effectiveness. [4] In other words, each person requires a different dosage, since needs may alter depending on a wide range of patient-and drug-related factors, such as the patient's disease state, genetic profiles, metabolism, age, weight, gender, and the pharmacokinetics of the drug.…”

“…[4,5] In this way, the administered dose could be below or above the optimum drug concentration for individual patients, resulting in toxicity, adverse effects, or minimal effectiveness. [4] In other words, each person requires a different dosage, since needs may alter depending on a wide range of patient-and drug-related factors, such as the patient's disease state, genetic profiles, metabolism, age, weight, gender, and the pharmacokinetics of the drug. [5] The current solutions to these problems, i.e., tablet splitting or compounded medication, are largely ineffective.…”

“…[1] Furthermore, compounded medications frequently suffer from dose accuracy issues and may lose their efficacy when patients disregard dosing recommendations. [4] The growing awareness of the limitations and problems of the one-size-fits-all approach has led to a rethinking of the current medicine's development, laying the basis of personalized medicine. [6] The shift to personalized medicine started approximately 20 years ago and has undergone an impressive acceleration over the past few years.…”

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“…A printer nozzle containing the binder (and/or medication) fluid is programmed to move along an x-y axis and jet the liquid onto the loose powder bed. The liquid drops moisten the powder, which causes the layer to harden and solidify, as illustrated in diagram48 .…”