An overview of poly(vinyl alcohol) and poly(vinyl pyrrolidone) in pharmaceutical additive manufacturing

Bianchi, Marica; Pegoretti, Alessandro; Fredi, Giulia

doi:10.1002/vnl.21982

Cited by 7 publications

(9 citation statements)

References 68 publications

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“…PVA may be a good fit for a number of biomedical pharmaceutical uses, especially when it comes to FDM’s development of sustained-release drug delivery systems. Additionally, PVA can be used for drug combinations with immediate release for an ideal absorption and for floating dosage forms [ 32 ].…”

Section: Short History and Applications Of Pvamentioning

confidence: 99%

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Polyvinyl Alcohol, a Versatile Excipient for Pharmaceutical 3D Printing

Couți,

Porfire,

Iovanov

et al. 2024

Polymers

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Three-dimensional (3D) printing in the pharmaceutical field allows rapid manufacturing of a diverse range of pharmaceutical dosage forms, including personalized items. The application of this technology in dosage form manufacturing requires the judicious selection of excipients because the selected materials must be appropriate to the working principle of each technique. Most techniques rely on the use of polymers as the main material. Among the pharmaceutically approved polymers, polyvinyl alcohol (PVA) is one of the most used, especially for fused deposition modeling (FDM) technology. This review summarizes the physical and chemical properties of pharmaceutical-grade PVA and its applications in the manufacturing of dosage forms, with a particular focus on those fabricated through FDM. The work provides evidence on the diversity of dosage forms created using this polymer, highlighting how formulation and processing difficulties may be overcome to get the dosage forms with a suitable design and release profile.

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Section: Short History and Applications Of Pvamentioning

confidence: 99%

“…Fully hydrolyzed PVA’s glass transition temperature for high molecular weight material was found to be 85 °C [ 17 , 32 ]. The melting point of PVA is between 180 and 220 °C.…”

Section: Pva Physical Properties and Pharmaceutical Gradesmentioning

confidence: 99%

Polyvinyl Alcohol, a Versatile Excipient for Pharmaceutical 3D Printing

Couți,

Porfire,

Iovanov

et al. 2024

Polymers

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“…Another outstanding application is the production of customized pharmaceutical solid solutions of polymeric matrix to safely introduce a pharmaceutical substance into the body, for a specific therapeutic effect [10]. The first product approved for successful commercialization for this type of device, produced via 3D printing, was Spritam, which has been used in the treatment of epilepsy since 2015 [11].…”

Section: Outstanding Applicationsmentioning

confidence: 99%

A Communication on FDM 3D Printing Polymeric Filaments with Applications in Biotechnology

Araújo¹

2023

RDMS

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3D printing by Fused Deposition Modeling (FDM) is characterized as a technology to produce threedimensional objects/models from the deposition of successive layers of the molten material of interest, on a work surface of a 3D printer. Most applications of the technique involve the use of conventional polymeric filaments for the production of parts with different geometries, which meet the specific demands of areas such as Engineering, Architecture and Education. In recent years, the manufacture and use of functional, biocompatible and/or biodegradable polymeric filaments containing active substances has been gaining prominence in the literature due to the possibility of producing prosthesis, artificial tissues and medicines with controlled release, at a relatively low cost, high precision and reproducibility. Here, we present a rapid communication about the possibilities of the FDM 3D printing using polymeric filaments, for applications in the field of biotechnology.

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“…Additive manufacturing (AM) is a technique characterized by the successive deposition of materials to construct objects in a layered fashion. [1][2][3] This process offers several advantages over traditional manufacturing methods. 4 AM has also brought about a significant transformation in advanced manufacturing through its ability to facilitate the fabrication of intricate and personalized lattice structures.…”

Section: Introductionmentioning

confidence: 99%

“…Additive manufacturing (AM) is a technique characterized by the successive deposition of materials to construct objects in a layered fashion 1–3 . This process offers several advantages over traditional manufacturing methods 4 .…”

Section: Introductionmentioning

confidence: 99%

The investigation of printing parameters effect on tensile characteristics for triply periodic minimal surface designs by Taguchi

Demir,

Temiz,

Pehlivan

2023

Polymer Engineering & Sci

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The advent of additive manufacturing also referred to as 3D printing, has brought about substantial changes in the industrial domain, as it possesses the capability to fabricate intricate items with enhanced cost‐efficiency and productivity. Fused Filament Fabrication (FFF) is a 3D printing process that has gained significant popularity due to its versatile capabilities and cost‐effectiveness. This paper investigates the impact of the printing parameters on the tensile characteristics of Triply Periodic Minimal Surface (TPMS) manufactured using FFF 3D printing. TPMS patterns have unique geometric properties and potential applications, making them an intriguing subject of study. The behavior of three different TPMS lattices with three printing parameters is investigated. Finding the best testing settings is done with the Taguchi method, and the data is analyzed with the Analysis of Variance (ANOVA) test. TPMS pattern was found to be the most effective parameter with 83.78%. While the highest strength was obtained in Schwarz diamond, the highest energy absorption was observed in the Gyroid structure. The contributions of printing parameters to tensile strength are line thickness, printing speed, and layer height, respectively. As line width and printing speed increase, both energy absorption and strength increase. Therefore, 0.40 mm line width and 60 mm/s printing speed give optimum values. When considered for energy absorption, the optimum value is 0.20 mm layer height, while when considered for strength, 0.10 mm layer height is the optimum value. The findings emphasize the importance of optimizing printing parameters for desired mechanical characteristics in 3D printed components and highlight the potential of TPMS structures in various applications. This research contributes to the growing knowledge in additive manufacturing and provides insights into optimizing FFF 3D printing for improved mechanical performance.

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An overview of poly(vinyl alcohol) and poly(vinyl pyrrolidone) in pharmaceutical additive manufacturing

Cited by 7 publications

References 68 publications

Polyvinyl Alcohol, a Versatile Excipient for Pharmaceutical 3D Printing

Polyvinyl Alcohol, a Versatile Excipient for Pharmaceutical 3D Printing

A Communication on FDM 3D Printing Polymeric Filaments with Applications in Biotechnology

The investigation of printing parameters effect on tensile characteristics for triply periodic minimal surface designs by Taguchi

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