Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering

Sun, Fengxin; Sun, Xiaodan; Wang, Hetong; Li, Chunxu; Zhao, Yu; Tian, Jingjing; Lin, Yuan‐Hua

doi:10.3390/ijms23105831

Cited by 32 publications

(25 citation statements)

References 74 publications

(77 reference statements)

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“…PLGA is an ideal polymeric substrate material for constructing a biomedical stent: i) PLGA can control the subsequent degradation cycle and mechanical properties by changing the ratio and initial molecular weight. [ 32 ] ii) PLGA has excellent biocompatibility and has been approved by the FDA. [ 33 ] Electrostatic spinning technology was used to produce the tubular stent ( Figure a,c,d; Figure S3, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite

Zhang

Wang

Wei

et al. 2023

Adv Healthcare Materials

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In the surgical treatment of urinary diseases, ureteral stents are commonly used interventional medical devices. Although polymer ureteral stents with polyurethane as the main constituent are widely used in the clinic, the need for secondary surgery to remove them and their propensity to cause bacterial infections greatly limit their effectiveness. To satisfy clinical requirements, an electrospinning‐based strategy to fabricate PLGA ureteral stents with silver@graphdiyne is innovated. Silver (Ag) nanoparticles are uniformly loaded on the surface of graphdiyne (GDY) flakes. It is found that the incorporation of Ag nanoparticles into GDY markedly increases their antibacterial properties. Subsequently, the synthesized and purified Ag@GDY is homogeneously blended with poly(lactic‐co‐glycolic acid) (PLGA) as an antimicrobial agent, and electrospinning along with high‐speed collectors is used to make tubular stents. The antibacterial effect of Ag@GDY and the porous microstructure of the stents can effectively prevent bacterial biofilm formation. Furthermore, the stents gradually decrease in toughness but increase in strength during the degradation process. The cellular and subcutaneous implantation experiments demonstrate the moderate biocompatibility of the stents. In summary, considering these performance characteristics and the technical feasibility of the approach taken, this study opens new possibilities for the design and application of biodegradable ureteral stents.

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Section: Resultsmentioning

confidence: 99%

Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite

Zhang

Wang

Wei

et al. 2023

Adv Healthcare Materials

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“…The in vivo biocompatibility and potential osteogenic effects of the PLGA blends in the scaffolds used in this study were novel, yet not unexpected. Due to its biocompatibility and biodegradability, PLGA has been used as an important component for nanocomposite scaffolds in many tissue-engineering studies [ 3 , 40 , 41 ]. The biological applications of PLGA alone are limited due to its hydrophobic properties, inferior mechanical integrity, and lack of osteogenic activity.…”

Section: Discussionmentioning

confidence: 99%

Xenogenic Implantation of Human Mesenchymal Stromal Cells Using a Novel 3D-Printed Scaffold of PLGA and Graphene Leads to a Significant Increase in Bone Mineralization in a Rat Segmental Femoral Bone Defect

et al. 2023

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Tissue-engineering technologies have the potential to provide an effective approach to bone regeneration. Based on the published literature and data from our laboratory, two biomaterial inks containing PLGA and blended with graphene nanoparticles were fabricated. The biomaterial inks consisted of two forms of commercially available PLGA with varying ratios of LA:GA (65:35 and 75:25) and molecular weights of 30,000–107,000. Each of these forms of PLGA was blended with a form containing a 50:50 ratio of LA:GA, resulting in ratios of 50:65 and 50:75, which were subsequently mixed with a 0.05 wt% low-oxygen-functionalized derivative of graphene. Scanning electron microscopy showed interconnected pores in the lattice structures of each scaffold. The cytocompatibility of human ADMSCs transduced with a red fluorescent protein (RFP) was evaluated in vitro. The in vivo biocompatibility and the potential to repair bones were evaluated in a critically sized 5 mm mechanical load-bearing segmental femur defect model in rats. Bone repair was monitored by radiological, histological, and microcomputed tomography methods. The results showed that all of the constructs were biocompatible and did not exhibit any adverse effects. The constructs containing PLGA (50:75)/graphene alone and with hADMSCs demonstrated a significant increase in mineralized tissues within 60 days post-treatment. The percentage of bone volume to total volume from microCT analyses in the rats treated with the PLGA + cells construct showed a 50% new tissue formation, which matched that of a phantom. The microCT results were supported by Von Kossa staining.

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“…High-biocompatibility artificial bone substitutes are currently receiving more attention. Because of its superior biocompatibility, tunable biodegradability, and mechanical characteristics, PLGA has been employed extensively in bone tissue engineering [ 61 , 62 ]. Additionally, it can promote the electrical conductivity of bone scaffold materials, promote osteoblast adherence and value addition, and stimulate mesenchymal stem cell differentiation into osteoblasts [ 63 ].…”

Section: The Applications Of Plga To Biomedical Researchmentioning

confidence: 99%

Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research

Lü

Cheng²,

Niu³

et al. 2023

Pharmaceuticals

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In recent years, biodegradable polymers have gained the attention of many researchers for their promising applications, especially in drug delivery, due to their good biocompatibility and designable degradation time. Poly (lactic-co-glycolic acid) (PLGA) is a biodegradable functional polymer made from the polymerization of lactic acid (LA) and glycolic acid (GA) and is widely used in pharmaceuticals and medical engineering materials because of its biocompatibility, non-toxicity, and good plasticity. The aim of this review is to illustrate the progress of research on PLGA in biomedical applications, as well as its shortcomings, to provide some assistance for its future research development.

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Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering

Cited by 32 publications

References 74 publications

Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite

Degradable Antimicrobial Ureteral Stent Construction with Silver@graphdiyne Nanocomposite

Xenogenic Implantation of Human Mesenchymal Stromal Cells Using a Novel 3D-Printed Scaffold of PLGA and Graphene Leads to a Significant Increase in Bone Mineralization in a Rat Segmental Femoral Bone Defect

Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research

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