Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research

Lü, Yue; Cheng, Dongfang; Niu, Ben; Wang, Xiuzhi; Wang, Aiping

doi:10.3390/ph16030454

Cited by 42 publications

(16 citation statements)

References 112 publications

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“…Therefore, several excipients were examined with the aim of increasing the MNs’ mechanical strength. Initially, poly(lactic- co -glycolic acid) (PLGA), a common copolymer with good mechanical properties, − was incorporated into the MN formulation, by either combining the Tri-C9 polymer with PLGA at the same ratio and casting into the MN mold or by forming trilayer MN by casting the PLGA into the tips followed by casting the Tri-C9 polymer solution and then the baseplate as stated earlier. While PLGA improved the insertion capability of the MNs in Parafilm, a phase separation between the two polymers was noticed, suggesting incompatibility between them (Figure S5).…”

Section: Resultsmentioning

confidence: 99%

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Dawud,

Edelstein-Pardo,

Mulamukkil

et al. 2024

ACS Appl. Bio Mater.

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Microneedle-based drug delivery offers an attractive and minimally invasive administration route to deliver therapeutic agents through the skin by bypassing the stratum corneum, the main skin barrier. Recently, hydrogel-based microneedles have gained prominence for their exceptional ability to precisely control the release of their drug cargo. In this study, we investigated the feasibility of fabricating microneedles from triblock amphiphiles with linear poly(ethylene glycol) (PEG) as the hydrophilic middle block and two dendritic side-blocks with enzyme-cleavable hydrophobic end-groups. Due to the poor formation and brittleness of microneedles made from the neat amphiphile, we added a sodium alginate base layer and tested different polymeric excipients to enhance the mechanical strength of the microneedles. Following optimization, microneedles based on triblock amphiphiles were successfully fabricated and exhibited favorable insertion efficiency and low height reduction percentage when tested in Parafilm as a skin-simulant model. When tested against static forces ranging from 50 to 1000 g (4.9–98 mN/needle), the microneedles showed adequate mechanical strength with no fractures or broken segments. In buffer solution, the solid microneedles swelled into a hydrogel within about 30 s, followed by their rapid disintegration into small hydrogel particles. These hydrogel particles could undergo slow enzymatic degradation to soluble polymers. In vitro release study of dexamethasone (DEX), as a steroid model drug, showed first-order drug release, with 90% released within 6 days. Eventually, DEX-loaded MNs were subjected to an insertion test using chicken skin and showed full penetration. This study demonstrates the feasibility of programming hydrogel-forming microneedles to undergo several mesophase transitions and their potential application as a delivery system for self-administration, increased patient compliance, improved efficacy, and sustained drug release.

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Section: Resultsmentioning

confidence: 99%

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Dawud,

Edelstein-Pardo,

Mulamukkil

et al. 2024

ACS Appl. Bio Mater.

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“…Poly(lactic-co-glycolic acid) is a biodegradable polymer formed by the random polymerization of a lactic acid monomer and hydroxyacetic acid (Figure 8C) [209][210][211]. Breaking the cyclic ester group can lead to the degradation of poly(lactic-co-glycolic acid), and the degradation products are lactic acid and hydroxyacetic acid, which are also by-products of human metabolism [210].…”

Section: Othersmentioning

confidence: 99%

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

Zhu,

Dou,

Zeng

et al. 2024

IJMS

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In clinical practice, tissue adhesives have emerged as an alternative tool for wound treatments due to their advantages in ease of use, rapid application, less pain, and minimal tissue damage. Since most tissue adhesives are designed for internal use or wound treatments, the biodegradation of adhesives is important. To endow tissue adhesives with biodegradability, in the past few decades, various biodegradable polymers, either natural polymers (such as chitosan, hyaluronic acid, gelatin, chondroitin sulfate, starch, sodium alginate, glucans, pectin, functional proteins, and peptides) or synthetic polymers (such as poly(lactic acid), polyurethanes, polycaprolactone, and poly(lactic-co-glycolic acid)), have been utilized to develop novel biodegradable tissue adhesives. Incorporated biodegradable polymers are degraded in vivo with time under specific conditions, leading to the destruction of the structure and the further degradation of tissue adhesives. In this review, we first summarize the strategies of utilizing biodegradable polymers to develop tissue adhesives. Furthermore, we provide a symmetric overview of the biodegradable polymers used for tissue adhesives, with a specific focus on the degradability and applications of these tissue adhesives. Additionally, the challenges and perspectives of biodegradable polymer-based tissue adhesives are discussed. We expect that this review can provide new inspirations for the design of novel biodegradable tissue adhesives for biomedical applications.

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“…However, the design of resorbable elastomers is still an emerging field ( Turner et al, 2022 ). Therefore, bioplastics such as resorbable polyesters have driven much attention, especially considering that some of them, such as PLGA, PLA, and PHAs, are already approved implant materials by regulatory agencies (the Food and Drug Administration and European Medical Agency) ( Nair et al, 2007 ; Ulery et al, 2011 ; Bano, 2018 ; Lu et al, 2023a ). Elastomers and bioplastics are mainly employed as 2D thin-film substrates that are assembled with electrical conductors to design multilayer electronic systems.…”

Section: Selecting Components For the Design Of Resorbable Conductive...mentioning

confidence: 99%

Resorbable conductive materials for optimally interfacing medical devices with the living

Sacchi,

Sauter-Starace,

Mailley

et al. 2024

Front. Bioeng. Biotechnol.

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Implantable and wearable bioelectronic systems are arising growing interest in the medical field. Linking the microelectronic (electronic conductivity) and biological (ionic conductivity) worlds, the biocompatible conductive materials at the electrode/tissue interface are key components in these systems. We herein focus more particularly on resorbable bioelectronic systems, which can safely degrade in the biological environment once they have completed their purpose, namely, stimulating or sensing biological activity in the tissues. Resorbable conductive materials are also explored in the fields of tissue engineering and 3D cell culture. After a short description of polymer-based substrates and scaffolds, and resorbable electrical conductors, we review how they can be combined to design resorbable conductive materials. Although these materials are still emerging, various medical and biomedical applications are already taking shape that can profoundly modify post-operative and wound healing follow-up. Future challenges and perspectives in the field are proposed.

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Properties of Poly (Lactic-co-Glycolic Acid) and Progress of Poly (Lactic-co-Glycolic Acid)-Based Biodegradable Materials in Biomedical Research

Cited by 42 publications

References 112 publications

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Hydrogel Microneedles with Programmed Mesophase Transitions for Controlled Drug Delivery

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

Resorbable conductive materials for optimally interfacing medical devices with the living

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