Application of 1H nuclear magnetic resonance spectroscopy to the analysis of β-lactam antibiotics and their common degradation products

Branch, Sarah K.; Casy, A. F.; Ominde, E.M.A.

doi:10.1016/0731-7085(87)80011-0

Cited by 41 publications

(15 citation statements)

References 49 publications

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“…Branch et al 8 pointed out that, with the aid of a highfield instrument, it is possible to observe the three-bond H-N-C-H6 proton-proton coupling, which is unequivocal evidence for the assignment. Thus, the assignment of 1 H NMR signals of most penicillins has been completed, and we can depend on the published data of penicillins.…”

Section: Nmr Spectroscopymentioning

confidence: 96%

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Synthesis and characterization of some penicillins modified with germanium‐containing moieties

Imafuku

Takeuchi

2004

Applied Organom Chemis

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Section: Nmr Spectroscopymentioning

confidence: 96%

“…The assignment of the H3 signal, which appears as a singlet, is unambiguous. However, the specific assignment of the Me3α/Me3β and H5/H6 signals (both separated only by less than 0.1 ppm) was carried out only for some compounds 8 and the assignments for the other compounds are based on the comparison with such data.…”

Section: Nmr Spectroscopymentioning

confidence: 99%

Synthesis and characterization of some penicillins modified with germanium‐containing moieties

Imafuku

Takeuchi

2004

Applied Organom Chemis

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“…Figure 1 shows the structure and assignment of the 1 H NMR chemical shifts for AMP according to published results [48,52]. The first region of interest is in the lower range where two singlets are observed from the CH3 protons around 1.42 ppm.…”

Section: Amp Degradationmentioning

confidence: 99%

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Smith

Adams

2017

Plasma

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This research focused on determining the effectiveness of non-thermal atmospheric pressure plasma as an alternative to advanced oxidation processes (AOP) for antibiotic removal in solution. For this study, 20 mM (6.988 g/L) solutions of ampicillin were treated with a floating electrode dielectric barrier discharge (FE-DBD) plasma for varying treatment times. The treated solutions were analyzed primarily using mass spectrometry (MS) and nuclear magnetic resonance spectroscopy (NMR). The preliminary product formed was Ampicillin Sulfoxide, however, many more species are formed as plasma treatment time is increased. Ampicillin was completely eliminated after five minutes of air-plasma treatment. The primary mechanism of ampicillin degradation by plasma treatment is investigated in this study.

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“…The first review written by Branch et al [6] reports on the application of 1 H NMR spectroscopy to the analysis of blactam antibiotics and their common degradation products.…”

Section: Introductionmentioning

confidence: 99%

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

Samanidou

Evaggelopoulou

Papadoyannis³

2006

J of Separation Science

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Natural penicillin (benzylpenicillin) is the oldest antibiotic observed by Alexander Fleming in 1928. To broaden its spectrum of activity, natural penicillin was modified, giving rise to a group of antibiotics under the name 'penicillins'. Although an increasing number of bacteria appear to be resistant to them, penicillins are used to treat a variety of bacterial infections including Gram-positive, Gram-negative aerobic and anaerobic bacteria. Consequently, they are widely used in human and veterinary medicine to prevent and treat diseases. This review covers the analytical methodologies, mainly chromatographic, employed to the penicillins determination in pharmaceutical formulations, biological fluids and in production-scale fermentations reported in the literature. Results of published assays are comparatively presented focusing on sample preparation regarding isolation and purification, chromatographic conditions and method validation. Information on chemical structure, spectrum of activity and action mechanism of common penicillins has also been given.

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Application of 1H nuclear magnetic resonance spectroscopy to the analysis of β-lactam antibiotics and their common degradation products

Cited by 41 publications

References 49 publications

Synthesis and characterization of some penicillins modified with germanium‐containing moieties

Synthesis and characterization of some penicillins modified with germanium‐containing moieties

Mechanism of Ampicillin Degradation by Non-Thermal Plasma Treatment with FE-DBD

Chromatographic analysis of penicillins in pharmaceutical formulations and biological fluids

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