Applicability of Mesenchymal Stem Cell-Derived Exosomes as a Cell-Free miRNA Therapy and Epigenetic Modifiers for Diabetes

Sharma, Shikha; Bhonde, Ramesh

doi:10.2217/epi-2023-0302

Cited by 3 publications

(1 citation statement)

References 113 publications

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“…Therefore, MSC exosomes can influence surrounding cells, modulating some pathways in the receiving cells. In particular, they are able to activate differentiation, stimulate proliferation, regulate the regeneration process, and, in general, increase cell survival (Figure 2) [93][94][95]. MSC-derived exosomes have already been used in experimental research to regulate RNA levels in certain types of cancer, including breast cancer and hepatocellular carcinoma [96,97].…”

Section: Therapeutic Applications Of Extracellular Vesicles and Secre...mentioning

confidence: 99%

Classical and Innovative Evidence for Therapeutic Strategies in Retinal Dysfunctions

Caruso,

Fields,

Rimondi

et al. 2024

IJMS

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The human retina is a complex anatomical structure that has no regenerative capacity. The pathogenesis of most retinopathies can be attributed to inflammation, with the activation of the inflammasome protein platform, and to the impact of oxidative stress on the regulation of apoptosis and autophagy/mitophagy in retinal cells. In recent years, new therapeutic approaches to treat retinopathies have been investigated. Experimental data suggest that the secretome of mesenchymal cells could reduce oxidative stress, autophagy, and the apoptosis of retinal cells, and in turn, the secretome of the latter could induce changes in mesenchymal cells. Other studies have evidenced that noncoding (nc)RNAs might be new targets for retinopathy treatment and novel disease biomarkers since a correlation has been found between ncRNA levels and retinopathies. A new field to explore is the interaction observed between the ocular and intestinal microbiota; indeed, recent findings have shown that the alteration of gut microbiota seems to be linked to ocular diseases, suggesting a gut–eye axis. To explore new therapeutical strategies for retinopathies, it is important to use proper models that can mimic the complexity of the retina. In this context, retinal organoids represent a good model for the study of the pathophysiology of the retina.

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Section: Therapeutic Applications Of Extracellular Vesicles and Secre...mentioning

confidence: 99%

Classical and Innovative Evidence for Therapeutic Strategies in Retinal Dysfunctions

Caruso,

Fields,

Rimondi

et al. 2024

IJMS

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KDM2B and its peptides promote the stem cells from apical papilla mediated nerve injury repair in rats by intervening EZH2 function

Cao,

Wang,

Xia

et al. 2024

Cell Proliferation

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How to improve the neurogenic potential of mesenchymal stem cells (MSCs) and develop biological agent based on the underlying epigenetic mechanism remains a challenge. Here, we investigated the effect of histone demethylase Lysine (K)‐specific demethylase 2B (KDM2B) on neurogenic differentiation and nerve injury repair by using MSCs from dental apical papilla (SCAP). We found that KDM2B promoted the neurogenic indicators expression and neural spheres formation in SCAP, and modified the Histone H3K4 trimethylation (H3K4me3) methylation on neurogenesis‐related genes. KDM2B improved the SCAP mediated recovery of motor ability at the early healing stage of spinal cord injury rats. Meanwhile, KDM2B acted as a negative regulator to its partner EZH2 during neurogenic differentiation, enhancer of zeste homologue 2 (EZH2) suppressed the neurogenic ability of SCAP. Further, the protein interaction between KDM2B and EZH2 was identified which decreased during neurogenic differentiation. On this basis, we revealed seven key protein binding sequences of KDM2B to EZH2, and synthesized KDM2B‐peptides based on these sequences. By the usage of KDM2B‐peptides, EZH2 function was effectively intervened and the neurogenic ability of SCAP was promoted. More, KDM2B‐peptides significantly improved the SCAP mediated functional recovery at SCI early phase. Our study revealed that KDM2B acted as a promotor to neurogenic differentiation ability of dental MSCs through binding and negatively regulating EZH2, and provided the KDM2B‐peptides as candidate agents for improving the neurogenic ability of MSCs and nerve injury repair.

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The emerging modulators of non-coding RNAs in diabetic wound healing

Aghayants,

Zhu,

et al. 2024

Front. Endocrinol.

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Diabetic wound healing is a complex physiological process often hindered by the underlying metabolic dysfunctions associated with diabetes. Despite existing treatments, there remains a critical need to explore innovative therapeutic strategies to improve patient outcomes. This article comprehensively examines the roles of non-coding RNAs (ncRNAs), specifically microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in regulating key phases of the wound healing process: inflammation, angiogenesis, re-epithelialization, and tissue remodeling. Through a deep review of current literature, we discuss recent discoveries of ncRNAs that have been shown to either promote or impair the wound healing process in diabetic wound healing, which were not covered in earlier reviews. This review highlights the specific mechanisms by which these ncRNAs impact cellular behaviors and pathways critical to each healing stage. Our findings indicate that understanding these recently identified ncRNAs provides new insights into their potential roles in diabetic wound healing, thereby contributing valuable knowledge for future research directions in this field.

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Applicability of Mesenchymal Stem Cell-Derived Exosomes as a Cell-Free miRNA Therapy and Epigenetic Modifiers for Diabetes

Cited by 3 publications

References 113 publications

Classical and Innovative Evidence for Therapeutic Strategies in Retinal Dysfunctions

Classical and Innovative Evidence for Therapeutic Strategies in Retinal Dysfunctions

KDM2B and its peptides promote the stem cells from apical papilla mediated nerve injury repair in rats by intervening EZH2 function

The emerging modulators of non-coding RNAs in diabetic wound healing

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