Applicability and Comparative Evaluation of Wet Granulation and Direct Compression Technology to Rauwolfia serpentina Root Powder: A Technical Note

Patra, Chinam Niranjan; Pandit, Hemant Kumar; Singh, Satya Prakash; Devi, M. Vimala

doi:10.1208/s12249-007-9015-7

Cited by 14 publications

(9 citation statements)

References 10 publications

(4 reference statements)

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“…The lower value of a for the granules revealed better flowability than pure drug cefuroxime axetil. Whereas lower value of 1/b for granules showed that it is less cohesive than cefuroxime axetil (Patra et al, 2008). This can also be attributed to the properties of high oil adsorption capacity and high specific surface area of neusilin US2.…”

Section: Kawakita Analysismentioning

confidence: 92%

Design and characterization of cefuroxime axetil biphasic floating minitablets

et al. 2014

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Biphasic floating minitablets of cefuroxime axetil were prepared by melt granulation technique using two different grades of gelucire namely 50/13 and 43/01 to maintain constant plasma drug concentration. Loading dose of cefuroxime axetil was formulated as immediate release (IR) minitablets by using hydrophilic grade of gelucire 50/13. Maintenance dose was formulated as floating sustained release (SR) minitablets by using hydrophobic grade of gelucire 43/01. The prepared IR and SR granules were subjected to micromeritic studies and scanning electron microscopy. Fourier transform infrared spectroscopy (FT-IR) study revealed that drug and selected carriers were compatible. In vitro dissolution study of optimized IR minitablets showed more than 85% of loading dose dissolved within 30 min. Optimized SR minitablets showed zero lag time with floating duration more than 12 h. The drug release from SR minitablets was linear with square root of time with non-Fickian diffusion-controlled release. The optimized batch of minitablets was filled into 0 size hard gelatin capsule. In vitro dissolution study for capsule showed an immediate burst release followed by SR up to 12 h. There is no significant change in dissolution data after storage at 40 C and 75% RH for three months. Microbiological assay of dissolution samples of optimized minitablets filled in capsules showed proportionate increase in inhibition of growth against Escherichia coli up to 12 h samples. In vivo bioavailability study in albino rabbits showed three times improvement in oral bioavailability.

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Section: Kawakita Analysismentioning

confidence: 92%

Design and characterization of cefuroxime axetil biphasic floating minitablets

et al. 2014

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“…CFSC showed more resistance to the applied load (higher P y value). The results therefore indicated that granules (WG) underwent plastic deformation more easily and rapidly than CFSC [28]. However, CFSC can be directly compressed as most of the properties are nearly similar to conventional granules (WG).…”

Section: Heckel Analysismentioning

confidence: 93%

“…The lower value of 1/b for CFSC compared to granules indicates that spherical crystals are less cohesive due to dense nature of particles. Generally, dense particles are less cohesive to enhance flowability [28].…”

Section: Kawakita Analysismentioning

confidence: 99%

Design and characterization of aceclofenac and paracetamol spherical crystals and their tableting properties

et al. 2015

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“…1) reveals no linearity at initial stages of compression for direct compression formulations and granules of all three drugs (DS, CPM, and IB), due to particle rearrangement at early stage of compression, i.e., at low pressure (47,48). Higher value of A for granules of all drugs as compare to PG and direct compression formulation indicates higher degree of fragmentation which may be attributed to larger particle size of granules.…”

Section: Pressure-relative Density Relationshipmentioning

confidence: 99%

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

2014

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Abstract. In the present work, an attempt has been made to screen Prosopis africana seed gum (PG), anionic polymer for extended release tablet formulation. Different categories of drugs (charge basis) like diclofenac sodium (DS), chlorpheniramine maleate (CPM), and ibuprofen (IB) were compacted with PG and compared with different polymers (charge basis) like xanthan gum (XG), hydroxypropyl methyl cellulose (HPMC-K100M), and chitosan (CP). For each drug, 12 batches of tablets were prepared by wet granulation technique, and granules were evaluated for flow properties, compressibility, and compactibility by Heckel and Leuenberger analysis, swelling index, in vitro dissolution studies, etc. It has been observed that granules of all batches showed acceptable flowability. According to Heckel and Leuenberger analysis, granules of PG-containing compacts showed similar and satisfactory compressibility and compactibility compared to granules of other polymers. PG showed significant swelling (P<0.05) compared to HPMC, and better than CP and XG. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) study showed no interaction between drugs and polymers. From all PG-containing compacts of aforesaid drugs, drug release was sustained for 12 h following anomalous transport. Especially, polyelectrolyte complex formation retarded the release of oppositely charged drug (CPM-PG). However, extended release was noted in both anionic (DS) and nonionic (IB) drugs, maybe due to swollen gel. All compacts were found to be stable for 3-month period during stability study. This concludes that swelling and release retardation of PG has close resemblance to HPMC, so it can be used as extended release polymer for all types of drugs.

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Applicability and Comparative Evaluation of Wet Granulation and Direct Compression Technology to Rauwolfia serpentina Root Powder: A Technical Note

Cited by 14 publications

References 10 publications

Design and characterization of cefuroxime axetil biphasic floating minitablets

Design and characterization of cefuroxime axetil biphasic floating minitablets

Design and characterization of aceclofenac and paracetamol spherical crystals and their tableting properties

Evaluation of Prosopis africana Seed Gum as an Extended Release Polymer for Tablet Formulation

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