Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats

Moura, Carolina Foot Gomes de; Ribeiro, Flávia Andressa Pidone; Lucke, Gabriela; Gollucke, Andréa Pitelli Boiago; Oshima, Celina Tizuko Fujiyama; Ribeiro, Daniel Araki

doi:10.1016/j.jtemb.2015.04.006

Cited by 12 publications

(5 citation statements)

References 45 publications

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“…Thus, femur of animals treated with cadmium showed DNA bone tissue lesions which are reported to be the consequence of cadmim-induced osteoporosis [55]. These findings are in agreement with those reported in an earlier study which proved that cadmium treatment modulated gene expression and signal transduction, reduced activities of proteins involved in antioxidant defenses [20].…”

Section: Effect Of Treatments On Bone Dna Aspectsupporting

confidence: 91%

“…Overproduction of reactive oxygen speacies (ROS) leads to increase lipid peroxidation and oxidative stress which play an important role in the toxicity of many xenobiotics [54]. ROS are involved in bone resorption with a direct contribution of osteoclast proliferation and simultaneously decreasing osteoblast activity [55]. Previous studies, in agreement with the present one, have clearly demonstrated that chronic cadmium exposure increases lipid peroxidation level and suppresses the antioxidant defence mechanisms in bone tissue.…”

Section: Effect Of Treatments On Bone Dna Aspectsupporting

confidence: 80%

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Therapeutic potential of Opuntia ficus indica extract against cadmium-induced osteoporosis and DNA bone damage in male rats

Taleb

Ncibi

Bkhairia

et al. 2022

J. Trop. Pharm. Chem.

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The purpose of the present study was to assess the protective effects of ‘Opuntia ficus indica’ (family Cactaceae) against osteoporosis induced by cadmium chloride in female Wistar rats. Experiments were carried out on 36 male Wistar rats (6-8 weeks old) divided into four groups of nine each: a control group, a group treated with cadmium (3,5 mg/kg /day) by subcutaneous injection, a group treated with Opuntia ficus indica extract (100 mg/Kg/day) by gavage, and a group treated with opuntia extract then treated with cadmium. After 10 weeks of treatment, animals from each group were rapidly sacri?ced by decapitation. Blood serum was obtained by centrifugation. Bone toxicity was estimated by examining femoral length and weight, calcium, phosphorus, vitamin D3 and alkaline phsphatase (ALP) levels, oxidative status and DNA aspects in femur tissue. Results showed that cadmium could induce hypocalcemia, hypophosphatemia, Vit D deficiency, increase in ALP level, and decrease in femur weight and length. Also, an oxidative stress evidenced by statistically signi?cant losses in the activities of catalase (CAT), superoxide-dismutase (SOD), glutathione-peroxidase (GPX) activities and an increase in lipids peroxidation level in bone tissue of cadmium-treated group compared with the control group. In addition, histological analysis in bone tissue of cadmium-induced rats revealed pronounced morphological alterations with areas of bone resorption and a loss of normal architecture of femur diaphysis bone as well as DNA fragmentation. However, administration of cactus extract attenuated cadmium-induced bone damage. The protective effect of the plant can be attributed to its antioxidant properties and the existence of phenolic acids and flavonoids, as highlighted by HPLC-based analysis. These findings indicate that ‘Opuntia ficus indica’ extract, can be used as a new option in nutraceutical field.

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Section: Effect Of Treatments On Bone Dna Aspectsupporting

confidence: 91%

Section: Effect Of Treatments On Bone Dna Aspectsupporting

confidence: 80%

Therapeutic potential of Opuntia ficus indica extract against cadmium-induced osteoporosis and DNA bone damage in male rats

Taleb

Ncibi

Bkhairia

et al. 2022

J. Trop. Pharm. Chem.

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“…It was also observed that the group exposed to cadmium increased genetic damage when compared to control group, while the groups treated with two juices had a significant reduction of genotoxicity. Our research group has previously demonstrated that such effects can also be attributed not only to antioxidant action, but also to chelating activity of grape and apple juices, since the polyphenols present in the juices bind to cadmium forming an inert compound, facilitating the excretion of this metal, and stimulating the DNA repair system [3].…”

Section: Discussionmentioning

confidence: 99%

“…Nowadays, pollution is a serious environmental concern as well as its impact on human health since prolonged exposure to environmental pollutants, such as non-essential metals, is related to etiology and pathogenesis for developing chronic degenerative diseases [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

et al. 2020

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Background The objective of this study was to evaluate protective effect of grape and apple juices against toxicity induced by cadmium in the kidney of rats. Methods A total of 20 male-Wistar rats were distributed into four groups (n=5): Control group: animals received an intraperitoneal (i.p.) injection of 0.9% saline solution and after 15 days, 1 mL of water was administered for 15 days, via gavage; Cadmium group: animals received an intraperitoneal injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1 mL of water was administered for 15 days via gavage; Cadmium+Grape Juice: animals received an i.p. injection of cadmium chloride (1.2 mg/kg), and after 15 days, 0.8 mL of grape juice was administered for 15 days, via gavage; Cadmium+Apple Juice: animals received i.p. injection of cadmium chloride (1.2 mg/kg) and after 15 days, 1.0 mL of apple juice was administered for 15 days, via gavage. Results Histopathological analysis revealed severe tubular lesion and necrosis in the group exposed to cadmium, while animals exposed to grape or apple juices showed a significant reduction of tissue injury. 8-OHdG immunoexpression, DNA damage, cytochrome C and catalase gene expressions and Toll like signaling pathway (TLR2, and pIKKα/β) decreased in animals treated with grape juice when compared to cadmium group. Conclusion Taken together, we conclude that grape and apple juices had a protective effect by means of antioxidant, antigenotoxic actions and for promoting tissue regeneration in the kidney of rats following cadmium intoxication.

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“…1)) (References in Table 1: Anti-cancer: Delphi et al, 2015[5]; Walia et al, 2014[28]; Schiavano et al, 2015[25]; Hung et al, 2015[10]; Li et al, 2014[21]; Kao et al, 2015[16]; Qiao et al, 2015[23]; Jedrychowski et al, 2010[12]; Le Marchand et al, 2000[19]; Anti-obesity and anti-diabetic effects: Jiang et al, 2016[14]; Sun et al, 2016[26]; Sampath et al, 2016[24]; O'Neil et al, 2015[22]; Bouderbala et al, 2016[2]; Fathy and Drees, 2016[7]; Dange and Deshpande, 2013[4]; Knekt et al, 2002[17]; Anti-inflammation: Jensen et al, 2014[13]; Espley et al, 2014[6]; Lee et al, 2014[20]; Hepato-protective: Cheng et al, 2014[3]; Krajka-Kuźniak et al, 2015[18]; Antigenotoxicity: Gomes de Moura et al, 2015[8]; Reduction of cardiotoxicity: Vineetha et al, 2014[27]; Etc. : Hodgson et al, 2016[9]).…”

mentioning

confidence: 99%

Apple as a source of dietary phytonutrients: an update on the potential health benefits of apple

Hyun

Jang

2016

EXCLI Journal; 15:Doc565; ISSN 1611-2156

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Apple juice attenuates genotoxicity and oxidative stress induced by cadmium exposure in multiple organs of rats

Cited by 12 publications

References 45 publications

Therapeutic potential of Opuntia ficus indica extract against cadmium-induced osteoporosis and DNA bone damage in male rats

Therapeutic potential of Opuntia ficus indica extract against cadmium-induced osteoporosis and DNA bone damage in male rats

Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

Apple as a source of dietary phytonutrients: an update on the potential health benefits of apple

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