Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

Handan, Bianca Andrade; Moura, Carolina Foot Gomes de; Cardoso, Caroline Margonato; Santamarina, Aline Boveto; Pisani, Luciana Pellegrini; Ribeiro, Daniel Araki

doi:10.1055/a-1221-4733

Cited by 12 publications

(2 citation statements)

References 43 publications

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“…The main harm of cadmium to the human body is kidney damage. Nearly 50% of the cadmium is accumulated in the kidney, especially in the proximal convoluted tubule, leading to kidney damage and chronic kidney disease [5][6][7][8]. Previous studies revealed that up to 7% of the global population suffers from chronic kidney disease caused by cadmium [9].…”

Section: Introductionmentioning

confidence: 99%

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

et al. 2021

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Kidney damages caused by cadmium are considered to be one of the most dangerous consequences for the human body. This study aimed to investigate the protective effects of fucoxanthin supplementation on mice models subjected to cadmium-induced kidney damage. The mice treated with cadmium chloride (CdCl 2 ) were observed to have significantly reduced the crosssection area of glomeruli. Cadmium exposure has also caused the damage of the structural integrity of mitochondria and increased blood urea nitrogen (BUN), kidney injury molecule 1 (KIM1), and neutrophil gelatinase associated lipocalin (NGAL) levels. Peroxidase (POD), superoxide dismutase (SOD), catalase (CAT), and ascorbate peroxidase (APX) levels in cadmium-exposed mice were markedly declined. Caspase3, caspase8, and caspase9 gene expressions in association with apoptosis were dramatically elevated in renal tissues. The CdCl 2 treated mice were orally administered with 50 mg/kg Shenfukang, 10 mg/kg, 25 mg/kg, and 50 mg/kg fucoxanthin for 14 days. The results revealed that high doses of fucoxanthin administration significantly decreased BUN, KIM1, NGAL levels, increasing POD, SOD, CAT, and ascorbate APX levels. Fucoxanthin administration also promoted recovery of the renal functions, micro-structural organization, and ultrastructural organization in the renal cells. In summary, the ameliorative effects of fucoxanthin supplementation against cadmium-induced kidney damage were mediated via inhibiting oxidative stress and apoptosis, promoting the recovery of structural integrity of mitochondria.

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Section: Introductionmentioning

confidence: 99%

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

et al. 2021

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“…Thus, it becomes meaningful to intensify the research on elucidating the phytochemicals responsible for the aforementioned effects in order to maximize health benefits. High phytochemical content provides apple with its antioxidant properties and the consumption of apple juice is reported to have antigenotoxic potential [23]. Apple is rich in phloridzin that is mainly found in Malus species [24].…”

Section: Discussionmentioning

confidence: 99%

In vitro Evaluation of Antigenotoxic Effects of Phloridzin

Sarimahmut¹,

VEKSHARİ²,

KARAALİ³

et al. 2022

Cumhuriyet Science Journal

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Phytochemicals have a vast number of properties contributing to human health by acting on numerous different mechanisms. Phloridzin, a phytochemical mainly found in Malus species, possesses diverse biological activities including anti-diabetic and antioxidative activities. Here, our aim is to explore antigenotoxic potential and proliferative effects of phloridzin on human lymphocytes in vitro by employing chromosome aberration, micronucleus and comet assays. Mitomycin C, both an anticancer and genotoxic agent, was utilized to induce genotoxicity. Phloridzin significantly suppressed the genotoxic effects of mitomycin C at 125-500 µg/mL concentrations in all assays used (p < 0.05). We also revealed that phloridzin and mitomycin C combination had a significantly negative effect on mitotic index (p < 0.05), whereas in general, gender differences did not play a role in manifestation of neither antigenotoxic nor antiproliferative activities of the combination.These results suggest that phloridzin is an antigenotoxic compound and its consumption may interfere with the activity of anticancer drugs that exert their effects based on genotoxic mechanisms.

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Folic acid‐induced animal model of kidney disease

2021

Anim Models and Exp Med

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Kidney disease may be generally classified clinically into two categories: acute kidney injury (AKI) and chronic kidney disease (CKD), both of which are tightly interconnected. 1-3 AKI can often develop in clinical settings in critically ill patients, leading to increased morbidity and mortality. 4,5 AKI is manifested by a rapid decline in the glomerular filtration rates (GFRs) 6 and its pathogenesis is complex, involving ischemia, sepsis, drug toxicity, and trauma. 7 If left unmanaged, AKI can develop into CKD, which is characterized by a progressive decrease in GFR, culminating in a gradual loss of renal function. 8 The transition from AKI to CKD can also be hastened by numerous risk factors such as obesity, hypertension, diabetes, and chronic inflammation. 9-11 Currently, there are no effective treatments for either AKI or CKD, stressing a continual need to elucidate the underlying pathological mechanisms of AKI and CKD. In this regard, animal models of kidney disease have been invaluable in that utilization of these animal models not only facilitates our understanding of the

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Protective Effect of Grape and Apple Juices against Cadmium Intoxication in the Kidney of Rats

Cited by 12 publications

References 43 publications

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities

In vitro Evaluation of Antigenotoxic Effects of Phloridzin

Folic acid‐induced animal model of kidney disease

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