Appetite‐Inducing Effects of Homoeriodictyol: Two Randomized, Cross‐Over Interventions

Hochkogler, Christina Maria; Liszt, Kathrin; Lieder, Barbara; Stöger, Verena; Stübler, Anna; Pignitter, Marc; Hans, Joachim; Widder, Sabine; Ley, Jakob P.; Krammer, Gerhard; Somoza, Veronika

doi:10.1002/mnfr.201700459

Cited by 14 publications

(18 citation statements)

References 39 publications

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“…In our study, reduced serotonin plasma concentrations underline the higher intake of total energy from the standardized breakfast after receiving the sucrose + lactisole solution compared to sucrose application. Such an association between serotonin plasma levels and energy intake in men has been shown before [ 37 ]. In addition, the results of this study find support in recent in vitro findings that showed an increased serotonin release in human gastric parietal cell line after exposure to caloric or non-caloric sweeteners.…”

Section: Discussionsupporting

confidence: 78%

Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects

et al. 2020

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Knowledge regarding the involvement of sweetness perception on energy intake is scarce. Here, the impact of glucose and sucrose sweetness, beyond their caloric load, on subsequent food intake and biomarkers of satiation was evaluated by co-administration of the sweet taste receptor inhibitor lactisole. A total of 27 healthy, male subjects received solutions of either 10% glucose w/o 60 ppm lactisole or 10% sucrose w/o 60 ppm lactisole. Subsequent food intake from a standardized breakfast was evaluated 2 h after receiving the respective test solution. Changes in postprandial plasma concentrations of cholecystokinin, ghrelin, and serotonin were determined over a period of 120 min, as was the body temperature. Administration of lactisole to the sucrose solution increased the energy intake from the subsequent standardized breakfast by 12.9 ± 5.8% (p = 0.04), led to a decreased Δ AUC of the body core temperature by 46 ± 20% (p = 0.01), and time-dependently reduced Δ serotonin plasma concentrations (−16.9 ± 6.06 ng/mL vs. −0.56 ± 3.7 ng/mL after sucrose administration, p = 0.03). The present study shows that lactisole increases energy intake and decreases plasma serotonin concentrations as well as body core temperature induced by sucrose, but not glucose. This finding may be associated with the different binding affinities of sucrose and glucose to the sweet taste receptor.

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Section: Discussionsupporting

confidence: 78%

Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects

et al. 2020

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“…Additionally, ghrelin, glucagon‐like‐peptide1 (GLP‐1), PYY 3–36 , and serotonin concentrations were measured in the plasma as orexigenic and anorexigenic markers. The crossover study design in this short‐term intervention trial was conducted based on previous works which reported an impact of other aroma active food constituents on food intake and hormonal regulation of satiety …”

Section: Introductionmentioning

confidence: 99%

“…The crossover study design in this short-term interven-tion trial was conducted based on previous works which reported an impact of other aroma active food constituents on food intake and hormonal regulation of satiety. [32,33]…”

Section: Introductionmentioning

confidence: 99%

Cinnamyl Isobutyrate Decreases Plasma Glucose Levels and Total Energy Intake from a Standardized Breakfast: A Randomized, Crossover Intervention

Hochkogler

Hoi

Lieder

et al. 2018

Molecular Nutrition Food Res

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ScopeCinnamon is associated with anti‐obesity effects, regulating food intake, improving plasma glucose levels and lipid profiles in vivo. In the present study, the impact of cinnamyl isobutyrate (CIB), one constituent of cinnamon, on ad libitum food intake from a standardized breakfast and outcome measures of hormonal regulation of appetite were investigated.Methods and resultsIn this randomized, short‐term crossover intervention study, a 75 g per 300 mL glucose solution solely (control) or supplemented with 0.45 mg CIB was administered to 26 healthy volunteers. Prior to and 2 h after receiving control or CIB treatment, subjective hunger perceptions were rated using a visual analog scale. Food intake from a standardized breakfast was assessed 2 h after treatments. Plasma peptide YY3–36, glucagon‐like‐peptide1, ghrelin, and serotonin as well as plasma glucose and insulin were measured in blood samples drawn at fasting and 15, 30, 60, 90, and 120 min after treatment. CIB administration decreased total energy intake and delta area under curve plasma glucose by 4.64 ± 3.51% and 49.3 ± 18.5% compared to control treatment, respectively.ConclusionsCIB, administered at a 0.45 mg bolus in 75 g glucose–water solution, decreased ad libitum energy intake from a standardized breakfast and postprandial plasma glucose levels.

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“…In multiple studies that recorded the outcomes over several hours on just one or two days, respectively, participants were instructed to refrain from exercise 24 to 48 h before test day [28,51,60,61,62,65,75] and to arrive after an overnight fast at the test center [52,57,62,69,70,76,86]. The bioactive phytochemical was mostly taken with a standardized meal, varying from a breakfast meal with approximately 1150 kJ (275 kcal) [73] to a breakfast buffet with a total amount of approximately 32,962 kJ (7878 kcal) [61].…”

Section: Resultsmentioning

confidence: 99%

Appetite-Suppressing and Satiety-Increasing Bioactive Phytochemicals: A Systematic Review

Stuby

Gravestock

Wolfram³

et al. 2019

Nutrients

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The prevalence of obesity is increasing worldwide. Bioactive phytochemicals in food supplements are a trending approach to facilitate dieting and to improve patients’ adherence to reducing food and caloric intake. The aim of this systematic review was to assess efficacy and safety of the most commonly used bioactive phytochemicals with appetite/hunger-suppressing and/or satiety/fullness-increasing properties. To be eligible, studies needed to have included at least 10 patients per group aged 18 years or older with no serious health problems except for overweight or obesity. Of those studies, 32 met the inclusion criteria, in which 27 different plants were tested alone or as a combination, regarding their efficacy in suppressing appetite/hunger and/or increasing satiety/fullness. The plant extracts most tested were derived from Camellia sinensis (green tea), Capsicum annuum, and Coffea species. None of the plant extracts tested in several trials showed a consistent positive treatment effect. Furthermore, only a few adverse events were reported, but none serious. The findings revealed mostly inconclusive evidence that the tested bioactive phytochemicals are effective in suppressing appetite/hunger and/or increasing satiety/fullness. More systematic and high quality clinical studies are necessary to determine the benefits and safety of phytochemical complementary remedies for dampening the feeling of hunger during dieting.

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Appetite‐Inducing Effects of Homoeriodictyol: Two Randomized, Cross‐Over Interventions

Abstract: NaHED demonstrated appetizing effects in healthy adults when administered with a glucose load. Long-term intervention studies are warranted to verify these effects in compromised subjects.

Cited by 14 publications

References 39 publications

Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects

Sweet Taste Antagonist Lactisole Administered in Combination with Sucrose, But Not Glucose, Increases Energy Intake and Decreases Peripheral Serotonin in Male Subjects

Cinnamyl Isobutyrate Decreases Plasma Glucose Levels and Total Energy Intake from a Standardized Breakfast: A Randomized, Crossover Intervention

Appetite-Suppressing and Satiety-Increasing Bioactive Phytochemicals: A Systematic Review

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