Appendicular schwannoma presenting as vague abdominal pain

Abstract

Appendicular schwannomas are very rare condition with nonspecific clinical symptoms and frequently recognized during pathological examination. They arise less frequently in the gastrointestinal tract and comprise ~1% of all malignant gastrointestinal tumours. We presented a rare case of an appendicular schwannoma that was discovered incidentally in a 25-year-old student diagnosed with appendicular mucocoele with a suspected obstructing tumoural lesion based on computed tomography findings. A colonoscopy examination showed a bulging, nodular, erythematous lesion at the base of the caecum (appendiceal orifice). Biopsies showed mixed inflammatory infiltration in the lamina propria, with lymphoid-filled formations. No evidence of dysplasia or neoplasia. Tumour markers were negative. Appendicular neoplasms, such as schwannomas of the appendix, are rarely associated with nonspecific clinical symptoms and are frequently recognized during pathological examination of the resected appendix. Laparoscopic surgery with a clear resection margin is the cornerstone of treatment for appendicular schwannoma, and it is associated with a favourable prognosis.

Histopathological patterns of primary malignant ovarian neoplasms in different age groups in Almadinah Almunawwarah region, KSA

“…Several molecular abnormalities, such as alteration in the expression of tumour suppressor genes ( BRCA-1, BRCA-2 ) 4 as well as dysfunction in the P53 and Kras genes, 1 play an important role in the development and prognosis of ovarian cancer.…”

Appendiceal schwannoma presenting as acute appendicitis

“…Our patient had tenderness and rebound tenderness in the right lower quadrant; consequently, this was a symptom of acute appendicitis, not of schwannoma itself. In fact, in approximately 30%-50% of appendiceal tumors, patients present clinical symptoms and signs of appendicitis [7] .…”

Gastric schwannoma (a case report)

“…Серед усіх пухлинних захворювань на частку доброякісних припадає всього 0,5-5,0 %, частка шванном становить не більше ніж 0,2 % всіх пухлин шлунка, до 4,0 % з-поміж усіх доброякісних новоутворень. Утім серед усіх органів шлунково-кишкового тракту шванному найчастіше виявляють у ділянці шлунка, рідше - в ділянці товстого кишківника, як виняток -в ділянці тонкої кишки [1][2][3].…”