Histopathological patterns of primary malignant ovarian neoplasms in different age groups in Almadinah Almunawwarah region, KSA

Abstract

Objectives In the literature, the epidemiological pattern of ovarian neoplasms in different age groups in the Almadinah Almunawwarah region in KSA has not been completely elucidated. Moreover, an unusually frequent diagnosis of adult granulosa cell tumour (AGCT) has been observed in patients in Almadinah Almunawwarah, KSA. This study aimed to describe the pattern of ovarian neoplasms in different age groups in the Almadinah Almunawwarah region with particular emphasis on AGCT. Methods Histopathological records of all ovarian specimens diagnosed from 2011 January to 2016 December were collected from the Maternity and Children Hospital in Almaadinah Almunawwarah, KSA. Hematoxylin and eosin (HE)-stained microscopic slides of serous and mucinous epithelial borderline neoplasms and of malignant epithelial, sex cord-stromal and germ line neoplasms were identified and examined. The tissue sections from the AGCT were stained immunohistochemically with BRCA-1 antibody. Results A total of 301 ovarian specimens were obtained. Of the specimens, 217 (72%) were neoplastic and 84 (28%) were non-neoplastic. In total, 135 (63%) of the neoplastic specimens were benign, 16 (7%) were borderline tumours, and 66 (30%) were malignant tumours. Moreover, 41 (62%) of the malignant tumours were surface epithelial carcinomas, 17 (26%) were sex cord-stromal tumours, and 8 (12%) were germ cell tumours. The incidence of AGCT was unusually high, which accounts for 26% (16/66) of all malignant ovarian neoplasms. Altered BRCA-1 expression was observed in only two specimens. Conclusion In this study, malignant ovarian neoplasms accounted for 30% of all neoplastic ovarian specimens, and the incidence of AGCT was remarkable. Such tumours did not show a significantly altered expression of BRCA-1. Further studies must be conducted to explore the underlying molecular causes of this condition.

Pathological Features of Ovarian Tumors, Diagnosed at a Tertiary Care Hospital in Afghanistan: A Cross-sectional Study

“…6,13,16 However, studies conducted in Nepal, Ghana and Nigeria showed that mature cystic teratoma was the commonest benign ovarian neoplasm. [19][20][21] The most common malignant tumor was serous cystadenocarcinoma and adult granulosa cell tumor, each constituting 3% of the all malignant cases followed by endometrioid adenocarcinoma (2.5%) and mucinous cystadenocarcinoma (2%) which apart from relatively higher incidence of adult granulosa cell tumor in our study, shows a concordance with the literature 20,22 that could be explained related to our study's small sample size, genetic or environmental factors. 3330…”

“…One-sided (75.7%) tumors were more common than bilateral (7.3%) and right ovarian involvement (42.4%) was more common than the left (33.3%), which was in concordance with findings of studies conducted in India, Iraq, and Bangladesh. 10,17,22,23 In terms of tumor consistency, 72.7% were cystic, 11.1% solid and 15.7% complex and only one case (0.5%) was not assessable due to diffuse pattern of the tumor. Tumors with cystic consistency were mostly benign constituting 88.3%, while malignant tumors were either solid or complex, each being 42.4% and 51.5%, respectively.…”

The Histopathological Patterns of Ovarian Neoplasms in Different Age Groups: A Retrospective Study in a Tertiary Care Center

“…Out of all neoplastic lesions, our results show that benign ovarian neoplasms were 64.4%, while the percentages of borderline and malignant neoplasms were 6.2% and 29.4%, respectively. Yousif et al had approximately similar findings in their patient population, which were 63% for benign, 7% for borderline, and 30% for malignant [ 19 ]. Abdullah and Bondagji found that the percentages of benign, borderline, and malignant neoplasms were 72.8%, 5.2%, 22%, respectively [ 13 ].…”

Overview on Screening and Prevalence of Ovarian Neoplasms in Saudi Arabia

“…Serous cystadenoma and serous cystadenocarcinoma are the most prevalent benign and malignant ovarian neoplasms, respectively. Malignant ovarian neoplasms are more common as people get older [1]. Another study in Riyadh indicated that most neoplastic ovarian tumors in children and adolescents are benign [2].…”

“…Ovarian carcinoma is the second most prevalent cancer of the female reproductive system and the fifth leading cause of cancer-related death in women. Ovarian cancer is the sixth most frequent cancer in Saudi women, with a mean age at diagnosis of 54 years and a wide age range of 5 to 97 years [1]. Globally, the prevalence varies.…”