Appendicitis as a possible safety signal for the COVID-19 vaccines

Mitchell, Joseph; Yue, Qun‐Ying

doi:10.1016/j.jvacx.2021.100122

Cited by 19 publications

(29 citation statements)

References 18 publications

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“…A previous publication by Mitchell et al . [ 6 ] reviewed cases of appendicitis following administration of COVID-19 vaccines reported to VigiBase, the World Health Organization database of individual case safety reports (ICSRs). They sought to identify relevant cases of appendicitis with COVID-19 vaccines as the suspected medicinal product from spontaneous reports.…”

Section: Discussionmentioning

confidence: 99%

Acute appendicitis following the COVID-19 vaccine

Oganesyan

Schäfer

Lesh

2022

Journal of Surgical Case Reports

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We report the case of a previously healthy 69-year-old female who developed appendicitis after receiving the third dose of the Pfizer-BioNTech Coronavirus Disease 2019 (COVID-19) vaccine; no other triggers were identified. We speculate that an association exists which may be mediated by colonic lymphoid hyperplasia, a condition that might be indicative of an enhanced immunological mucosal response to antigenic stimulation. As widespread vaccination coverage continues, it is crucial to monitor and accurately report the adverse reactions that may otherwise remain unidentified in vaccination trials. Therefore, we suggest that adults experiencing spontaneous, severe abdominal pain following COVID-19 vaccination may benefit from seeking emergent medical care. Likewise, providers should have a low threshold to consider and evaluate patients for appendicitis. If a true causal link is identified, the risk must also be deliberated in context with the millions of patients who have been safely vaccinated and the known morbidity and mortality from COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

Acute appendicitis following the COVID-19 vaccine

Oganesyan

Schäfer

Lesh

2022

Journal of Surgical Case Reports

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“…Moreover, regarding the post-vaccination appendicitis occurrences, some data suggest a correlation with lymphadenopathy, but it is highlighted that the infections’ status should also be reported, since a multisystem inflammatory response can present as abdominal pain and both mimic and cause appendicitis, as in COVID-19 [ 99 ]. The immunological response could possibly play a role in the development of appendicitis.…”

Section: Mrna Vaccination Against Covid-19 and Diagnosis Of Spontaneo...mentioning

confidence: 99%

“…The immunological response could possibly play a role in the development of appendicitis. Vaccinations against COVID-19 elicit strong Th1 immune responses, and there is a hypothesized relationship between an elevated Th1 immune response and a subtype of appendicitis that is more likely to necessitate surgery [ 99 ].…”

Section: Mrna Vaccination Against Covid-19 and Diagnosis Of Spontaneo...mentioning

confidence: 99%

Current Evidence in SARS-CoV-2 mRNA Vaccines and Post-Vaccination Adverse Reports: Knowns and Unknowns

Mouliou

Dardiotis

2022

Diagnostics

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The novel mRNA vaccinations against COVID-19 are gaining worldwide attention for their efficacy, as well as the diagnosis of some post-vaccination-reported adverse reactions. In this state-of-the-art review article, we present the current evidence regarding mainly the diagnosis of spontaneous allergic reactions, the skin occurrences, the vascular, blood, endocrine and heart events, the respiratory reports, the gastrointestinal, hepatic and kidney events, the reproductive and pregnancy issues and the muscle events, as well as the ear, eye, neurologic and psychiatric events following mRNA vaccination against COVID-19. We further present some evidence regarding the mRNA strategies and we discuss our expert opinion on the knowns and the unknowns towards the topic.

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“…Post-authorization monitoring has proven that adenoviral vector and mRNA-based vaccines are generally safe. However, various rare side effects were reported, including myocarditis, pericarditis [ 5 , 6 ], appendicitis [ 7 ], liver [ 8 ], pancreatic [ 9 ] and kidney injuries [ 10 ], and thrombotic thrombocytopenia [ 11 , 12 ]. The exact mechanisms behind these events require further investigations, although several potential explanations were offered [ 5 , 13 – 15 ].…”

Section: Introductionmentioning

confidence: 99%