Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics

Barriocanal, L.A.; Palacios, Mafalda; Benitez, Gualberto; Benitez, Sussam; Jimenez, J.; Jimenez, Nora; Rojas, Vicenta

doi:10.1016/j.yrtph.2008.02.006

Cited by 146 publications

(120 citation statements)

References 17 publications

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“…As yet, conflicting data about stevioside's effects on insulin resistance and diabetes in humans have been published. 39,40 However, the study groups were very small. Moreover, patients were already treated with PPAR agonists and/or statins, which are known to increase insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice

et al. 2009

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Objective: Stevioside is a non-caloric natural sweetener that does not induce a glycemic response, making it attractive as sweetener to diabetics and others on carbohydrate-controlled diets. Obesity is frequently associated with insulin resistance and increased inflammation and oxidative stress. Therefore, we investigated its effects on insulin resistance, inflammation and oxidative stress related to atherosclerosis in obese insulin-resistant mice.Research design: Twelve-week-old mice were treated with stevioside (10 mg kg À1 , n ¼ 14) or placebo (n ¼ 20) for 12 weeks. Results: Stevioside had no effect on weight and triglycerides, but lowered glucose and insulin. Stevioside treatment improved adipose tissue maturation, and increased glucose transport, insulin signaling and antioxidant defense in white visceral adipose tissues. Together, these increases were associated with a twofold increase of adiponectin. In addition, stevioside reduced plaque volume in the aortic arch by decreasing the macrophage, lipid and oxidized low-density lipoprotein (ox-LDL) content of the plaque. The higher smooth muscle cell-to-macrophage ratio was indicative for a more stable plaque phenotype. The decrease in ox-LDL in the plaque was likely due to an increase in the antioxidant defense in the vascular wall, as evidenced by increased Sod1, Sod2 and Sod3. Circulating adiponectin was associated with improved insulin signaling and antioxidant defense in both the adipose tissue and the aorta of stevioside-treated mice. Conclusion: Stevioside treatment was associated with improved insulin signaling and antioxidant defense in both the adipose tissue and the vascular wall, leading to inhibition of atherosclerotic plaque development and inducing plaque stabilization.

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Section: Discussionmentioning

confidence: 99%

Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice

et al. 2009

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“…Stevia consists of stevioside and rebaudioside, among other molecules, and rebaudioside had greater sweetness than stevioside (Barriocanal et al, 2008). Despite the difference in rebaudioside in the two kinds of stevia, they showed similar sweetener potency.…”

Section: Group Selectionmentioning

confidence: 96%

Development of pitanga nectar with different sweeteners by sensory analysis: ideal pulp dilution, ideal sweetness, and sweetness equivalence

2014

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“…Usual consumption of these compounds decreases the content of blood cholesterol by maintaining the lipid profile levels (Atteh et al 2008). It also improves blood coagulation and cell regeneration, suppresses neoplastic growth and strengthens blood vessels (Wingard et al 1980;Jeppesen et al 2003;Barriocanal et al 2008;Maki et al 2008).…”

Section: High Blood Pressure and Cardiovascular Effectsmentioning

confidence: 99%

Stevioside and rebaudioside A - predominant ent-kaurene diterpene glycosides of therapeutic potential: a review

Gupta¹,

Purwar²,

Sundaram³

et al. 2016

Czech J. Food Sci.

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Gupta E., Purwar S., Sundaram S., Tripathi P., Rai G. (2016): Stevioside and rebaudioside A -predominant ent-kaurene diterpene glycosides of therapeutic potential -a review. Czech J. Food Sci., 34: 281-299.Stevia rebaudiana (Bertoni) is a Paraguayan perennial herb of the family Asteraceae. The leaves contain a great amount of secondary metabolites with a wide range of important biological activities commonly known as steviol glycosides which differ in their molecular configuration, power of sweetness and their taste profile. Out of various steviol glycosides, the main compounds of interest are diterpenoid glycosides of ent-kaurene type extracted from the leaves of this plant as non-toxic, thermally stable, low-calorie natural sweeteners stevioside and rebaudioside A. These glycosides are a high-quality sugar substitute or dietary supplement with diverse applications in the medicinal world along with the food and beverage industry. This review article is aimed at the chemistry of stevioside and rebaudioside A, possible biosynthetic pathways, their metabolism and acceptable daily intake along with a broad spectrum of pharmacological and therapeutic applications.

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Apparent lack of pharmacological effect of steviol glycosides used as sweeteners in humans. A pilot study of repeated exposures in some normotensive and hypotensive individuals and in Type 1 and Type 2 diabetics

Cited by 146 publications

References 17 publications

Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice

Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice

Development of pitanga nectar with different sweeteners by sensory analysis: ideal pulp dilution, ideal sweetness, and sweetness equivalence

Stevioside and rebaudioside A - predominant ent-kaurene diterpene glycosides of therapeutic potential: a review

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