Apparent Diffusion Coefficient Mapping for Sinonasal Diseases: Differentiation of Benign and Malignant Lesions

Sasaki, Makoto; Eida, Sato; Sumi, Misa; Nakamura, Takashi

doi:10.3174/ajnr.a2434

Cited by 72 publications

(68 citation statements)

References 18 publications

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“…The ADC values of lymphomas were lower than those of squamous cell carcinomas (p , 0.001) and adenoid cystic carcinomas (p , 0.001), and this finding is similar to prior studies. 18,19 In addition, the present study found that there was no significant difference in ADC values between squamous cell carcinomas and adenoid cystic carcinomas (p 5 1.00). Although inflammatory lesions showed lower ADC values in benign lesions of the tongue, they were still higher than those of malignant tumours (p 5 0.001).…”

mentioning

confidence: 38%

“…Wang et al 20 found there was no significant difference in the ADC values between inflammatory and malignant masticator reported that the ADC value of masticator space malignancy was significantly lower than that of masticator space infection. Sasaki et al 18 also demonstrated that DWI could differentiate inflammatory from malignant tumours in the sinonasal area. The different results may be owing to different pathologies of patients as well as different data acquisitions.…”

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confidence: 98%

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Differentiation of benign and malignant lesions of the tongue by using diffusion-weighted MRI at 3.0 T

Li¹,

Cheng²,

Zhang³

et al. 2015

Dentomaxillofacial Radiology

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confidence: 38%

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confidence: 98%

Differentiation of benign and malignant lesions of the tongue by using diffusion-weighted MRI at 3.0 T

Li¹,

Cheng²,

Zhang³

et al. 2015

Dentomaxillofacial Radiology

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“…The ADC values of malignant neck lesions have been found to be lower than benign lesions by a significant rate in many studies (9,11,14). This situation is linked to the histopathological differences between benign and malignant lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Sasaki et al (14) compared ADC values in a study of sinonasal masses and found that ADC values above 0. /s cutoff value determined in our study had 81.25% sensitivity and 78.57% specificity to distinguish benign versus malignant head and neck masses.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted imaging in the head and neck region: usefulness of apparent diffusion coefficient values for characterization of lesions

Şerifoğlu

Öz²,

Damar³

et al. 2015

Diagn Interv Radiol

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ORIGINAL ARTICLE PURPOSEWe aimed to evaluate the role of apparent diffusion coefficient (ADC) values calculated from diffusion-weighted imaging for head and neck lesion characterization in daily routine, in comparison with histopathological results. METHODSNinety consecutive patients who underwent magnetic resonance imaging (MRI) at a university hospital for diagnosis of neck lesions were included in this prospective study. Diffusion-weighted echo-planar MRI was performed on a 1.5 T unit with b factor of 0 and 1000 s/mm 2 and ADC maps were generated. ADC values were measured for benign and malignant whole lesions seen in daily practice. RESULTS Diagnosis of head and neck lesions is difficult due to the complicated anatomic structure and different histological components of the many tissues that the neck contains. Imaging of head and neck lesions is not only important for diagnosis of lesions, but also for differentiation of benign lesions from malignant lesions and staging of tumors. While conventional imaging methods mainly evaluate morphological properties, their value is limited in recognizing prognostic characteristics such as benign-malignant differentiation of lesions (1). Routine magnetic resonance imaging (MRI) is a time-consuming method, which is sensitive to differences between examiners and may require the use of contrast material. With development of rapid MRI sequences (such as echo-planar [EPI], fast advanced spin echo [FASE], split echo acquisition of fast spin echo [SPLICE]), the sensitivity to susceptibility artifacts limiting the use of MRI for the head and neck region and limitations linked to duration have been significantly reduced (2, 3).Diffusion-weighted magnetic resonance imaging (DW-MRI) is a short sequence produced from EPI, FASE, SPLICE sequences. DW-MRI is sensitive to the randomized (Brownian) motion of water molecules at a microscopic level, which provides functional information about tissues. DW-MRI was initially used to diagnose early stroke in the brain and to evaluate brain masses (4-6). Previous studies have shown that rapid growth of high-grade tumors like astrocytoma and lymphoma causes hypercellularity, which leads to limitation of the diffusion of water molecules. Nowadays, apparent diffusion coefficient (ADC) maps calculated from DW-MRI sequences are being increasingly used to provide quantitative data for head and neck lesion diagnosis. In malignant lesions, the DW-MRI signal increases and signal loss is observed on ADC maps (5,7,8). Many researchers benefited from this feature of DW-MRI and evaluated the effectiveness of DW-MRI for head and neck lesion identification, benign-malignant differentiation, and characterization of malignant lesions (9-11).In this prospective study, head and neck lesions that are seen in daily routine were evaluated using DW-MRI, and the role of ADC values in lesion characterization was investigated with the guidance of histopathological results. Methods PatientsFrom January 2012 to January 2014, 90 consecutive patients underwent MRI for diag...

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“…La secuencia de difusión -diffusion-weighted imaging (DWI)-suelen ser úti-les para diferenciar neoplasias benignas y malignas, dado que las lesiones malignas tienen un coeficiente de difusión aparente (ADC) significativamente más bajo con respecto a los tumores benignos y las lesiones inflamatorias. Sin embargo, existe un solapamiento significativo del ADC de los procesos benignos y malignos; la exactitud diagnóstica global proporcionada por la medición del ADC (79%, según Sasaki M. y colaboradores) todavía no es adecuada para diferenciar de manera fiable entre los dos previo a la cirugía [6]. Por lo tanto, cuando se habla que una lesión nasosinusal tiene un ADC bajo nos referimos a que existe un alto grado de sospecha de malignidad.…”

Section: Materials Y Métodounclassified

Resonancia magnética en el diagnóstico y seguimiento de la patología nasosinusal

et al. 2017

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Apparent Diffusion Coefficient Mapping for Sinonasal Diseases: Differentiation of Benign and Malignant Lesions

Abstract: BACKGROUND AND PURPOSE:CT and MR imaging features of benign and malignant sinonasal lesions are often nonspecific. Therefore, we evaluated the ADC-based differentiation of these lesions.

Cited by 72 publications

References 18 publications

Differentiation of benign and malignant lesions of the tongue by using diffusion-weighted MRI at 3.0 T

Differentiation of benign and malignant lesions of the tongue by using diffusion-weighted MRI at 3.0 T

Diffusion-weighted imaging in the head and neck region: usefulness of apparent diffusion coefficient values for characterization of lesions

Resonancia magnética en el diagnóstico y seguimiento de la patología nasosinusal

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