Apparent content curves: description and analytical applications. Resolution of binary mixtures

Estellés, Maria; Sáez, Rosana; Ciges, M. D. San Martín

doi:10.1007/bf00321910

Cited by 17 publications

(2 citation statements)

References 21 publications

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“…Th e HPLC analysis was performed with a 1100 HPLC system with UV detection, producer Agilent Technologies (USA), equipped with Luna C18 column (150 × 4.6 mm, 3 μm, Phenomenex). since it was fi rst published [10] and the same notation has been used in the present study.…”

Section: Instrumentsmentioning

confidence: 99%

“…At fi rst, spectral behavior of AML and AT was studied for their quantitative spectrophotometric determination. Th en, the apparent content curve (ACC) method was applied for the simultaneous determination of both substances in industrial tablets [10]. Since the ACC method is considered a secondary method, quantitative determination was also performed by HPLC method, considered as a reference method.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Simultaneous Determination of Atorvastatin and Amlodipine in Industrial Tablets by Apparent Content Curve and HPLC Methods

Imre

Kacsó

Muntean

2013

Acta Medica Marisiensis

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Introduction: This study proposes the simultaneous determination of atorvastatin and amlodipine in industrial tablets by a quantitative spectrophotometric method, named the apparent content curve method, test method, and by an HPLC method with UV detection as reference method.Materials and methods: A synthetic mixture and two fixed medicinal combinations containing amlodipine and atorvastatin were investigated by the apparent content curve method, a simple and relatively inexpensive UV-VIS spectrophotometric method based on a mathematical approach derived from the Lambert-Beer law. The results were compared with those obtained by an HPLC method.Results: A good correlation of the results was obtained, the difference between the pair results was not significant (p >0.05).Conclusions: The proposed spectrophotometric method is an easier and cheaper alternative for the quantitative determination of amlodipine and atorvastatin in industrial fixed-dose combinations.

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Section: Instrumentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%