Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Chen, Jianxin; Gao, Kuo; Liu, Tiegang; Zhao, Haitao; Wang, Juan; Wu, Hao; Liu, Bing; Wang, Wei

doi:10.14233/ajchem.2013.15890

Cited by 26 publications

(17 citation statements)

References 125 publications

(195 reference statements)

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“…Plants of Lauraceae are rich sources of bioactive alkaloids [ 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. The majority of alkaloids isolated from Beilschmiedia species possess aporphine skeletons ( 71 , Table 3 ) or benzylisoquinoline ( 72 ) skeletons.…”

Section: Chemical Constituentsmentioning

confidence: 99%

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

et al. 2015

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Plants of the Lauraceae family are widely used in traditional medicine and are sources of various classes of secondary metabolites. Two genera of this family, Beilschmiedia and Endiandra, have been the subject of numerous investigations over the past decades because of their application in traditional medicine. They are the only source of bioactive endiandric acid derivatives. Noteworthy is that their biosynthesis contains two consecutive non-enzymatic electrocyclic reactions. Several interesting biological activities for this specific class of secondary metabolites and other constituents of the two genera have been reported, including antimicrobial, enzymes inhibitory and cytotoxic properties. This review compiles information on the structures of the compounds described between January 1960 and March 2015, their biological activities and information on endiandric acid biosynthesis, with 104 references being cited.

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Section: Chemical Constituentsmentioning

confidence: 99%

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

et al. 2015

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“…The increasing numbers of publications reflect the research intensity and importance of this field, as well as the bright prospect for drug development from these compounds. Some excellent earlier reviews on the chemical structures and biological properties of isolated isoquinoline alkaloids have contributed significantly to the general scientific understanding of this kind of compounds 5,6,8–12,17–21 . However, during the past 5 years, significant studies and novel technologies, such as metabolomics, were widely reported and used to identify alkaloids from plants.…”

Section: Introductionmentioning

confidence: 99%

Biologically active isoquinoline alkaloids covering 2014–2018

Shang

Yang

Morris‐Natschke

et al. 2020

Medicinal Research Reviews

129

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Isoquinoline alkaloids, an important class of N-based heterocyclic compounds, have attracted considerable attention from researchers worldwide since the early 19th century. Over the past 200 years, many compounds from this class were isolated, and most of them and their analogs possess various bioactivities. In this review, we survey the updated literature on bioactive alkaloids and highlight research achievements of this alkaloid class during the period of 2014-2018. We reviewed over 400 molecules with a broad range of bioactivities, including antitumor, antidiabetic and its complications, antibacterial, antifungal, antiviral, antiparasitic, insecticidal, anti-inflammatory, antioxidant, neuroprotective, and other activities. This review should provide new indications or directions for the discovery of new and better drugs from the original naturally occurring isoquinoline alkaloids.

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“…5,7,8 Recently, two aporphine-type BIAs, corytuberine from C. japonica and magnoflorine from Magnolia grandiflora , have had their possible biosynthetic pathways documented in C. japonica and P. somniferum , respectively. 9,10 CYP80-based reactions have been employed in many steps of simple BIA production. 8−11 In this pathway, CYP80G2 is responsible for hydroxylation and phenol C–C coupling.…”

Section: Introductionmentioning

confidence: 99%

Coregulation of Biosynthetic Genes and Transcription Factors for Aporphine-Type Alkaloid Production in Wounded Lotus Provides Insight into the Biosynthetic Pathway of Nuciferine

et al. 2018

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Lotus ( Nelumbo nucifera Gaertn.) contains various bioactive compounds, with benzylisoquinoline alkaloids (BIAs) as one of the major groups. The biosynthetic pathways of two major bioactive BIAs in this plant, nuciferine and N -nornuciferine, are still not clear. Therefore, several genes related to BIA biosynthesis were searched from the lotus database to study the role of key genes in regulating these pathways. In this study, the expression profiles of NCS , CNMT , 6 OMT , CYP 80 G 2, and WRKY TFs were investigated in mechanically wounded lotus leaves. It was found that the accumulation of nuciferine and N -nornuciferine significantly increased in the mechanically wounded lotus leaves in accordance with the relative expression of putative CYP 80 G 2 and one WRKY transcription factor ( NNU_ 24385), with the coregulation of CNMT . Furthermore, the role of methyltransferase-related genes in this study suggested that methylation of the isoquinoline nucleus to yield a methylated-BIA structure may occur at the N position before the O position. Altogether, this study provides improved understanding of the genes regulating BIA biosynthesis under stressed conditions, which could lead to improvements in BIA production from the commercial lotus.

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Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Cited by 26 publications

References 125 publications

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

Endiandric Acid Derivatives and Other Constituents of Plants from the Genera Beilschmiedia and Endiandra (Lauraceae)

Biologically active isoquinoline alkaloids covering 2014–2018

Coregulation of Biosynthetic Genes and Transcription Factors for Aporphine-Type Alkaloid Production in Wounded Lotus Provides Insight into the Biosynthetic Pathway of Nuciferine

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