Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells

Nie, Fangyuan; Liang, Yan; Jiang, Bing; Li, Xiabing; Xun, Hang; He, Wei; Lau, Hay Tong; Ma, Xiaofeng

doi:10.1007/s13277-015-4020-z

Cited by 51 publications

(44 citation statements)

References 29 publications

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“…More recently, ginkgolic acids (Oh et al, ) and a variety of natural products from Chinese medicine (Cheng et al, ) and spices (Jiang et al, ) have been shown to inhibit FASN. Additional natural product FASN inhibitors with cytotoxic effects on BC cell lines include tannic acid (Nie et al, ), sea buckthorn procyanidins (Wang et al, ), α‐Mangostin (Li et al, ), stilbene glycosides from rhubarb (Li et al, ), and amentoflavone (Lee et al, ).…”

Section: Oncogenic Antigen 519mentioning

confidence: 99%

Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered

Kinlaw

Baures

Lupien

et al. 2016

Journal Cellular Physiology

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Brisk fatty acid (FA) production by cancer cells is accommodated by the Warburg effect. Most breast and other cancer cell types are addicted to fatty acids (FA), which they require for membrane phospholipid synthesis, signaling purposes, and energy production. Expression of the enzymes required for FA synthesis is closely linked to each of the major classes of signaling molecules that stimulate BC cell proliferation. This review focuses on the regulation of FA synthesis in BC cells, and the impact of FA, or the lack thereof, on the tumor cell phenotype. Given growing awareness of the impact of dietary fat and obesity on BC biology, we will also examine the less-frequently considered notion that, in addition to de novo FA synthesis, the lipolytic uptake of preformed FA may also be an important mechanism of lipid acquisition. Indeed, it appears that cancer cells may exist at different points along a “lipogenic-lipolytic axis”, and FA uptake could thwart attempts to exploit the strict requirement for FA focused solely on inhibition of de novo FA synthesis. Strategies for clinically targeting FA metabolism will be discussed, and the current status of the medicinal chemistry in this area will be assessed.

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Section: Oncogenic Antigen 519mentioning

confidence: 99%

Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered

Kinlaw

Baures

Lupien

et al. 2016

Journal Cellular Physiology

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“…Plant derived antioxidant compounds are considered safe to be used as possible agents for the inhibition of inflammation (Mut‐Salud et al, ). In that case, tannic acid is a natural polyphenol which are applied to improve human health, including treatments of ulcers, burns, hemorrhoids, stomatitis, tonsillitis, (Nie et al, ), antioxidant, anti‐inflammatory, anticarcinogenic, antimutagenic, antitumor, and antimicrobial activities (Karuppagounder et al, ; Sen et al, ). Tannic acid can be easily found in leaves, roots, bark, and fruits of diverse plant varieties, especially in tea, grapes, coffee, and other plants (Gulįin, Huyut, Elmastas, & Aboul‐Enein, ).…”

Section: Introductionmentioning

confidence: 99%

Anti‐neuroinflammatory effects of tannic acid against lipopolysaccharide‐induced BV2 microglial cells via inhibition of NF‐κB activation

Zhong

et al. 2019

Drug Development Research

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Microglia mediated neuroinflammation is known to cause various neurodegenerative and neurological ailments. Tannic acid is a natural polyphenol which has been reported to possess antioxidant, anti‐inflammatory, anticarcinogenic, antimutagenic, antitumor, and antimicrobial activities. As there are no reports till date on the anti‐neuroinflammatory effects of tannic acid, this study was conducted to analyze the possible mechanism and pathway involved in the prevention of neuroinflammation by tannic acid in BV2 microglial cells. BV2 microglial cells were pretreated with tannic acid (10, 25, and 50 μM/mL) and induced with lipopolysaccharide (LPS; 1 μM/mL) to assess the production of reactive oxygen species (ROS), nitric oxide (NO), prostaglandin E2 (PGE2), pro‐inflammatory cytokines (IL‐6, IL‐1β, and TNF‐α), and nuclear factor‐kappa B (NF‐κB) protein expressions through western blotting. The results showed that LPS significantly activated the BV2 cells via toll‐like receptor 4 to induce elevated productions of ROS, NO, PGE2, IL‐6, and IL‐1β. However, tannic acid was able to reverse all the neuroinflammatory effects of LPS‐induced BV2 cells in a dose‐dependent manner. Collectively, the anti‐inflammatory effects of tannic acid on LPS‐induced BV2 microglial cells are attributed to the inhibition of ROS formation and the suppression of NF‐κB pathway activation. Tannic acid could be a potential therapeutic agent for the treatment of neurological related disorders.

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“…In contrast to the results of the above mentioned studies, no differences in the sensitivity to TA between MCF7 and MDA-MB-231 breast cancer cells were observed in the investigation of Nie et al [30]. One reason of this discrepancy might be the difference in TA concentrations applied in both studies which make the two approaches difficult to compare.…”

Section: Breast Cancer Cellsmentioning

confidence: 68%

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

et al. 2020

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Purpose of Review This short review is aimed at providing an updated and comprehensive report on tannic acid biological activities and molecular mechanisms of action most important for cancer prevention and adjuvant therapy. Recent Findings Tannic acid (TA), a mixture of digallic acid esters of glucose, is a common ingredient of many foods. The early studies of its anti-mutagenic and anti-tumorigenic activity were mostly demonstrated in the mouse skin model. This activity has been explained by its ability to inhibit carcinogens activation, as well as antioxidant and anti-inflammatory properties. Recently, the cell cycle arrest, apoptosis induction, reduced rate of proliferation, and cell migration and adhesion of several cancer cell lines as a result of TA treatment were described. The underlining mechanisms include modulation of signaling pathways such as EGFR/Jak2/STATs, or inhibition of PKM2 glycolytic enzyme. Moreover, epithelial-to-mesenchymal transition prevention and decrease of cancer stem cells formation by TAwere also reported. Besides, TAwas found to be potent chemosensitizer overcoming multidrug resistance. Eventually, its specific physicochemical features were found useful for generation of drug-loaded nanoparticles. Summary TA was shown to be a very versatile molecule with possible application not only in cancer prophylaxis, as was initially thought, but also in adjuvant cancer therapy. The latter may refer to chemosensitization and its application as a part of drug delivery systems. More studies are required to better explore this subject. In addition, the effect of TA on normal cells and its bioavailability have to better characterized.

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Apoptotic effect of tannic acid on fatty acid synthase over-expressed human breast cancer cells

Cited by 51 publications

References 29 publications

Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered

Fatty Acids and Breast Cancer: Make Them on Site or Have Them Delivered

Anti‐neuroinflammatory effects of tannic acid against lipopolysaccharide‐induced BV2 microglial cells via inhibition of NF‐κB activation

Tannic Acid: Specific Form of Tannins in Cancer Chemoprevention and Therapy-Old and New Applications

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