Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

Caruso, Sarah; Poon, Ivan K. H.

doi:10.3389/fimmu.2018.01486

Cited by 398 publications

(382 citation statements)

References 71 publications

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“…EVs can be categorized based on their size and biogenesis into three major groups: 1) apoptotic bodies, 2) microvesicles, and 3) exosomes (Table ) . Apoptotic bodies are vesicles of 1–5 μm in size, produced by cellular fragmentation and blebbing of the plasma membrane during apoptosis . Microvesicles, also known as shed vesicles/shed microvesicles, range from 50 to 1000 nm in size and are produced by direct outward budding and fission of the plasma membrane into the extracellular space .…”

Section: Introductionmentioning

confidence: 99%

Exosomes in Inflammation and Inflammatory Disease

et al. 2019

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Exosomes are a subset of extracellular vesicles released by all cell types and involved in local and systemic intercellular communication. In the past decade, research into exosomes has swelled as their important role in the mediation of health and disease has been increasingly established and acknowledged. Exosomes carry a diverse range of cargo including proteins, nucleic acids, and lipids derived from their parental cell that, when delivered to the recipient cell, can confer pathogenic or therapeutic effects through modulation of immunity and inflammation. In this review, the role of exosomes on mediation of immune and inflammatory responses, and their participation in diseases with a significant inflammatory component is discussed. The considerable potential for exosomes in therapy and diagnosis of inflammatory diseases is also highlighted.

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Section: Introductionmentioning

confidence: 99%

Exosomes in Inflammation and Inflammatory Disease

et al. 2019

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“…Exosomes and microvesicles have been shown to participate in antigen presentation, immune modulation, antitumour immunity and autoimmunity. EVs can exhibit immune suppressing or activation depending on the specific circumstances and the content . EVs can modulate immune responses by transporting damage‐associated molecular patterns (DAMPs), cytokines and functional microRNAs.…”

Section: Biological Functions Of Evsmentioning

confidence: 99%

“…EVs can exhibit immune suppressing or activation depending on the specific circumstances and the content. 21 EVs can modulate immune responses by transporting damage-associated molecular patterns (DAMPs), cytokines and functional microRNAs.…”

Section: Evs In Immune Modulationmentioning

confidence: 99%

New insight into the role of extracellular vesicles in kidney disease

Feng

Tang

et al. 2018

J Cellular Molecular Medi

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Extracellular vesicles (EVs) are released to maintain cellular homeostasis as well as to mediate cell communication by spreading protective or injury signals to neighbour or remote cells. In kidney, increasing evidence support that EVs are signalling vesicles for different segments of tubules, intra‐glomerular, glomerular‐tubule and tubule‐interstitial communication. EVs released by kidney resident and infiltrating cells can be isolated from urine and were found to be promising biomarkers for kidney disease, reflecting deterioration of renal function and histological change. We have here summarized the recent progress about the functional role of EVs in kidney disease as well as challenges and future directions involved.

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“…An assortment of lipids, proteins and nucleic acids can be loaded into EVs either as luminal cargo or as a component of the EVs membrane providing signaling capacity for intercellular communication. EVs can be broadly split into three main classes: exosomes, formed from an endocytic pathway, microvesicles that are directly shed from the plasma membrane, and apoptotic bodies, which are shed from cells undergoing apoptosis (Caruso and Poon, 2018;van Niel et al, 2018). EVs can be trafficked both locally and systemically and have been isolated from a wide range of biological fluids, including blood (Crawford, 1971;Emanueli et al, 2016) and pericardial fluid (Beltrami et al, 2017;Kuosmanen et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

In vivo characterisation of endogenous cardiovascular extracellular vesicles in larval and adult zebrafish

Scott

Ballesteros

Bradshaw

et al. 2019

Preprint

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Ischaemic cardiac injury results in a complex coordinated cellular response that enables effective damage control and recovery. Intercellular communication is integral to the coordination of these repair responses in complex tissue contexts. Extracellular vesicles (EVs) facilitate molecular transport across extracellular space, allowing local and systemic signaling during homeostasis and in disease. Extensive in vitro studies have described the biogenesis, cargos and functional roles of EV populations but the characterisation of endogenously produced EVs in vivo is still in its infancy. Here we use larval and adult transgenic zebrafish to characterize endogenous cardiovascular EVs. Using a membranetethered fluorophore reporter system, cell-type specific EVs can be tracked in vivo by high spatiotemporal resolution light sheet imaging and modified flow cytometry methods allows these EVs to be extracted and assessed ex vivo. Importantly, we show that ischaemic cardiac injury models dynamically alter EV production during repair.

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Apoptotic Cell-Derived Extracellular Vesicles: More Than Just Debris

Cited by 398 publications

References 71 publications

Exosomes in Inflammation and Inflammatory Disease

Exosomes in Inflammation and Inflammatory Disease

New insight into the role of extracellular vesicles in kidney disease

In vivo characterisation of endogenous cardiovascular extracellular vesicles in larval and adult zebrafish

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