Apoptosis of lymph node and peripheral blood cells in ovine Johne's disease

Silva, Kumudika de; Browne, Sally; Begg, Douglas J.; Whittington, Richard J.; Emery, D.L.

doi:10.1016/j.vetimm.2013.08.001

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…In paratuberculosis this antigen specific CD4 T cell depletion has been observed in particular when studying local intestinal T cell responses [ 12 ]. The induction of T cell apoptosis as a result of T cell – macrophage interaction in ovine MAP infection has also been described [ 70 ].…”

Section: Adaptive Immunity During Paratuberculosis Infectionmentioning

confidence: 99%

The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter

Koets

Eda

Sreevatsan

2015

Vet Res

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Johne’s disease or paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), occurs in domestic and wild animals worldwide, causing a significant economic loss to livestock industries. After a prolonged incubation time, infected cattle shed MAP bacilli into feces and spread the disease to an uninfected animal population. It is largely unknown how (or whether) the interplay between the pathogen and the host immunity determines timing of shedding after the long incubation time. Such information would provide an understanding of pathogenesis in individual animals and the epidemiology of MAP infection in animal populations. In this review, we summarize current knowledge of bovine Johne’s disease pathology, pathogenesis, immunology and genetics. We discuss knowledge gaps that direly need to be addressed to provide a science-based approach to diagnostics and (immuno)prophylaxis. These knowledge gaps are related to anatomical/clinical manifestation of MAP invasion, interaction of bacteria with phagocytes, granuloma formation, shedding, establishment and kinetics of adaptive immune responses in the pathogenesis of the disease. These topics are discussed at the molecular, cellular and tissue levels with special attention to the within host dynamics including the temporal and the spatial context relevant for the various host-pathogen interactions.

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Section: Adaptive Immunity During Paratuberculosis Infectionmentioning

confidence: 99%

The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter

Koets

Eda

Sreevatsan

2015

Vet Res

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“…Johne's disease (JD) or Paratuberculosis (PTBC) is a chronic wasting condition of ruminants and other domestic and wild animals, caused by Mycobacterium avium subspecies paratuberculosis (MAP) characterized by chronic enteritis of the small intestine diminishing an animal's ability to take up adequate nutrients resulting in the subsequent loss in body condition and eventual death (De Silva et al, 2013). PTBC is an economically important disease in sheep global industry due to lower milk production, reduced slaughter value due to profound weight loss of ewes, early culling of infected animals, and eventually death (Nielsen and Toft, 2009).…”

Section: Introductionmentioning

confidence: 99%

First Pathological, Molecular and Serological Investigation of Ovine Johne's Disease (Paratuberculosis) in Northeastern Algeria

Rezig¹,

Bouzid²,

Atia³

et al. 2021

BUASVMCN-VM

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Paratuberculosis (PTCB) or Johne's disease (JD) caused by a slow growing acid fast bacillus Mycobacterium avium subspecies paratuberculosis (MAP), is an infectious disease of many species including humans. The disease is responsible for important economic losses to livestock industry worldwide. Although the disease is widespread, it had not been studied in Algerian sheep. In this study we inspected the presence of the infection in sheep (aged 2 years old or older) using histopathology and IS900-PCR techniques in randomly 378 tissues (ileum, ileoceacale valve and lymph nodes) and fecal samples. Gross lesions were detected in 16 (4%) of samples. Histopathological examination revealed the presence of pathognomonic lesions of JD in 61 (14%) animals. Ziehl-Neelsen (ZN) staining of tissue samples was positive in 28 (7%) cases. MAP-DNA was detected in 34 (9%) fecal samples. 14 (4%) animals were tested positive for antibodies against MAP. This study showed that not only ovine paratuberculosis present in Algeria but infected animals are excreting the bacteria in feces. This could be a significant threat for other ruminants and humans. Other studies should be carried out in order to better understand the prevalence and the molecular epidemiology of MAP in the country.

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Diseases of the Alimentary Tract–Ruminant

2017

Veterinary Medicine

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Apoptosis of lymph node and peripheral blood cells in ovine Johne's disease

Cited by 3 publications

References 21 publications

The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter

The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter

First Pathological, Molecular and Serological Investigation of Ovine Johne's Disease (Paratuberculosis) in Northeastern Algeria

Diseases of the Alimentary Tract–Ruminant

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