Apoptosis-Inducing Effect of Pogostemin A Isolated from the Aerial Parts of<i>Pogostemon auricularius</i>Against the Human Lung Cancer Cells

Tran, Linh Thuy Thi; Ho, Duc Viet; Le, Dung Viet; Phan, Kiem Van; Nguyen, Hoai Thi; Raal, Ain

doi:10.1080/22311866.2019.1687334

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…2α, 3α, 23-trihydroxy-13α, 27-cyclours-11-en-28-oic acid, a triterpene acid isolated from the aerial parts of Glechoma longituba , is responsible for NCI-H460 cell cycle arrest, the induction of ROS-mediated apoptosis, and the nullification of NF-κB activity [ 279 ]. The exposure of human lung cancer cell line SK-LU-1 cells to pogostemin A, a meroterpenoid isolated from the aerial parts of Pogostemon auricularius , triggered apoptosis and caspase-3 activation [ 280 ].…”

Section: The Lamiaceae Family Plantsmentioning

confidence: 99%

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Sitarek

Merecz-Sadowska

Śliwiński

et al. 2020

Cancers

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It is predicted that 1.8 million new cancer cases will be diagnosed worldwide in 2020; of these, the incidence of lung, colon, breast, and prostate cancers will be 22%, 9%, 7%, and 5%, respectively according to the National Cancer Institute. As the global medical cost of cancer in 2020 will exceed about $150 billion, new approaches and novel alternative chemoprevention molecules are needed. Research indicates that the plants of the Lamiaceae family may offer such potential. The present study reviews selected species from the Lamiaceae and their active compounds that may have the potential to inhibit the growth of lung, breast, prostate, and colon cancer cells; it examines the effects of whole extracts, individual compounds, and essential oils, and it discusses their underlying molecular mechanisms of action. The studied members of the Lamiaceae are sources of crucial phytochemicals that may be important modulators of cancer-related molecular targets and can be used as effective factors to support anti-tumor treatment.

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Section: The Lamiaceae Family Plantsmentioning

confidence: 99%

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Sitarek

Merecz-Sadowska

Śliwiński

et al. 2020

Cancers

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“…8 Natural products constitute a substantial repository of potential cancer treatments. [9][10][11] Hence, given the effectiveness and availability of natural products, these resources are regarded 1 as potential antineoplastic candidates. Drug development is a time-consuming and challenging process that begins with target identification and continues through progressive optimization experiments and pre-clinical studies.…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals Derived from Goniothalamus elegans Ast Exhibit Anticancer Activity by Inhibiting Epidermal Growth Factor Receptor

Tran

Pham

Dang

et al. 2022

Natural Product Communications

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Cancer is a major health burden and a leading cause of death worldwide, with numerous new molecules being studied and developed as therapeutic agents. In this study, the cytotoxicity of compounds derived from Goniothalamus elegans was evaluated for possible anticancer activity. It was observed that the crude methanol extract of G. elegans exerted the strongest cytotoxic activity against SW-480, AGS, and SK-LU-1 cell lines. In addition, two isolated alkaloids—namely, lysicamine and liriodenine—also showed strong inhibitory ability against similar cancer cell lines. To further investigate the compounds’ mechanism of action, a molecular docking approach was utilized to evaluate the potential of the two candidates to interact with the epidermal growth factor receptor. This assay estimated that lysicamine and liriodenine acquired protein binding affinities of −8.8 and −9.7 kcal/mol, respectively. Finally, the stabilities of the ligand–protein complexes were evaluated using molecular dynamics simulations of 100 ns each.

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“…18,19 Our previous studies of the biological and phytochemical characteristics of P. auricularius collected in Quang Tri province reported that isolated meroterpenoids, triterpenes, and phloroglucinol derivatives demonstrate moderate or strong inhibition of certain cancer cell lines such as the human colon cancer cell line (SW480), epidermal carcinoma cell line (KB), gastric cancer cell line (AGS), liver tumor cell line (HepG2), and human lung cancer cell line (LU-1). [20][21][22][23][24] In Vietnam, P. auricularius morphology is described in the Flora of Vietnam as having the following characteristics: stem 0.4-2 m tall, prostrate basally; apex branching; petiole rarely to 1.2 cm; leaf blade oblong, yellow strigose, with scattered impressed glands, base rounded; flower continuous or occasionally interrupted at base; calyx long as corolla; stamens exserted sections bearded; nutlets brown, subglobose. [15][16][17] However, little has been anatomically and micromorphologically done on the species P. auricularius except a previous study on the structure and function of glandular trichomes.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morpho-Anatomical Study And Botanical Identification of Pogostemon auricularius (L.) Hassk. (Lamiaceae)

Tran

Nguyen²,

Nguyen

et al. 2022

Science Progress

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Pogostemon Desf . includes a wide range of taxa found in subtropical and tropical areas. Few works, however, have studied microanatomical characteristics of Pogostemon species and as yet identified features of Pogostemon auricularius (L.) Hassk. Thus, in this paper, we examined the taxonomic implications of root, stem and leaf morphology for species P. auricularius collected from Quang Tri Province. Light microscopy was mainly used in our study. Qualitative characters like stem quadrangular, hirsute; leaves opposite, ovate, margin serrulate; calyx campanulate; corolla small with separate equal lobes have been found in P. auricularius. Epidermal anatomy on the aerial parts of the species like epidermal cell shape, anticlinal walls, trichomes types, stomata types and calcium oxalate crystals types were examined as well. Quantitative characters like the length and width of leaf blade and inflorescence; the size of oil droplet, stomata and calcium oxalate crystals measured provided taxonomic significance. Based on identifying morphological characteristics of P. auricularius, we aimed to contribute to the taxonomic investigation into the genus Pogostemon and give relative morphological and microanatomical features compared with other taxa.

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Apoptosis-Inducing Effect of Pogostemin A Isolated from the Aerial Parts ofPogostemon auriculariusAgainst the Human Lung Cancer Cells

Cited by 6 publications

References 28 publications

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines

Phytochemicals Derived from Goniothalamus elegans Ast Exhibit Anticancer Activity by Inhibiting Epidermal Growth Factor Receptor

Morpho-Anatomical Study And Botanical Identification of Pogostemon auricularius (L.) Hassk. (Lamiaceae)

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