Apoptosis in reproductive biology

Felici, Massimo De

doi:10.1038/sj.cdd.4400237

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The degeneration of developmental germ cells has been known for many years (for a review, see Bartke, 1995;De Felici, 1997). This degeneration has been recently characterized as apoptosis, and the developmental pattern of germ cell apoptosis has been reported in mice Mori et al, 1997;Wang et al, 1998), hamsters (Miething, 1992), and rats (Boulogne et al, 1999a).…”

Section: Apoptosis Of Pgc and Gonocytesmentioning

confidence: 99%

Genetic and Cellular Analysis of Male Germ Cell Development

OLASO,

HABERT

2000

Journal of Andrology

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The evolution of the germline has been studied for many decades. Although the pathway of germ cell primordial migration and the kinetic evolution of the gonocytes are well known, their genetic and cellular controls are poorly understood. Recently, a genetic approach using gene knockout and a cellular investigation using several germ cell culture models has allowed a better understanding of the involvement of several genes and factors in the development of germ cells during fetal and neonatal life. Because of the obvious importance of the development of primordial germ cells and gonocytes in adult fertility and its eventual alteration by toxins or xenobiotics, a better knowledge of these interactions appears as an important research area.

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Section: Apoptosis Of Pgc and Gonocytesmentioning

confidence: 99%

Genetic and Cellular Analysis of Male Germ Cell Development

OLASO,

HABERT

2000

Journal of Andrology

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Role of apoptosis and Fas/FasL system in the oogenesis of the spotted ray Torpedo marmorata

Ricchiari

Barbara

Liguoro

et al. 2003

Molecular Reproduction Devel

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In the present paper we investigated the role played by apoptosis during oogenesis in the cartilagineous fish Torpedo marmorata. TEM, TUNEL and immunohistochemical techniques were employed to specifically reveal morphological and biochemical hallmarks of apoptosis in specimens from birth to sexual maturity. Data obtained demonstrate that apoptosis occurs in prefollicular oocyte selection, in maintaining the homeostasis of granulosa in healthy growing oocyte and in resorbing atretic follicles. In this respect, the involvement of apoptosis in Torpedo marmorata oogenesis closely parallels that found in mammals, thus confirming that strategies of germ cell selection among vertebrates have been evolutively preserved. Mol. Reprod. Dev. 66: 54–59, 2003. © 2003 Wiley‐Liss, Inc.

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