Apomorphine potentiates vagal bradycardia

Montastruc, P; Damase‐Michel, Christine; Montastruc, Jean‐Louis

doi:10.1016/0014-2999(89)90365-8

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…can be regulated through activation of presynaptic muscarinic and alpha-adrenergic receptors (Wetzel and Brown, 1985;Mc Gratten et al 1987). however, to our knowledge only a few studies have considered the involvement of dopamine receptors in this regulation (Montastruc et al 1985;1989).…”

Section: Introductionmentioning

confidence: 99%

Effects of quinpirole on autonomic nervous control of heart rate in rats

Roquebert

Morán

Sauvage

et al. 1992

Fundamemntal Clinical Pharma

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The effects of quinpirole, a specific dopamine DA2 receptor agonist, on autonomic nervous control of heart rate, were studied in normotensive pithed rats, by analysing its action on the tachycardia and bradycardia evoked by electrical stimulation of the cardioaccelerator (10 V; 1 ms; 0.5, 1, 3, 6 Hz) and vagus (10 V; 1 ms; 3, 6, 9 Hz) nerves respectively. Quinpirole (10-50-100 micrograms kg-1 iv) reduced the cardioacceleration elicited by electrical stimulation but not that by noradrenaline (3 micrograms kg-1 iv). The effect on electrical stimulation was blocked by domperidone (0.5 mg kg-1 iv) but not by SCH 23390 (0.2 mg kg-1 iv) or idazoxan (0.3 mg kg-1 iv). At 1, 5, 10, 30 micrograms kg-1 iv, quinpirole decreased vagal but not acetylcholine-induced bradycardia. The effect on electrical stimulation was inhibited by domperidone (0.5 mg kg-1 iv) but not by SCH 23390 (0.2 mg kg-1 iv), prazosin (0.1 mg kg-1 iv) or idazoxan (0.3 mg kg-1 iv). The data point to the presence of presynaptic and/or ganglionic dopamine receptors in the sympathetic and parasympathetic innervation of the rat heart, where stimulation inhibits the release of neuromediators.

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Section: Introductionmentioning

confidence: 99%

Effects of quinpirole on autonomic nervous control of heart rate in rats

Roquebert

Morán

Sauvage

et al. 1992

Fundamemntal Clinical Pharma

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“…14 Apomorphine is known to potentiate vagal bradycardia in the dog through stimulation of DA 2 presynaptic receptors located on vagal nerve endings. 13 In our patient, the cardioinhibitory syncope was conceivably due to bradycardia, sinus arrest, atrioventricular block, a combination of these disturbances, or even asystole alone.…”

Section: Commentsmentioning

confidence: 67%

Dopamine Hypersensitivity in Migraine: Role in Apomorphine Syncope

et al. 1995

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There is some evidence supporting a potential role of hypersensitivity of the dopaminergic system in the pathogenesis of migraine. In this case report, we describe a syncopal episode in a patient with migraine without aura after the administration of a very low dose of apomorphine, a classical agonist of dopaminergic receptors. The absence of cardiovascular risk factors in this patient suggests that the clinical event might have been caused by hypersensitivity of the dopaminergic system.

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“…Náuseas e vômitos são alguns dos principais sintomas não dolorosos que ocorrem antes ou durante a migrânea 6,7 . Redução da absorção e da contratilidade gástrica, hipotensão, ocasionalmente síncope podem também ocorrer durante crises de migrânea 8,9 .…”

Section: Discussionunclassified

Mudança no padrão biológico da migrânea com aura após a utilização da tetrabenazina: relato de caso

Piovesan

Lange²,

Teive

et al. 2000

Arq. Neuro-Psiquiatr.

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RESUMO -A participação do sistema dopaminérgico na fisiopatologia da migrânea tem sido proposta a partir de recentes conquistas genéticas. Uma possível hipereatividade dos receptores dopaminérgicos DRD2 tornou as evidências mais contundentes neste sentido. Descrevemos paciente masculino, 31 anos, portador de distonia generalizada, secundária a hipóxia perinatal. Aos 16 anos, começou a ter crises de cefaléia que preenchiam os critérios para migrânea com aura. Três anos após tratamento da distônia com tetrabenazina, observou-se nítida redução da frequência, intensidade e duração das crises. Durante dois períodos, superiores a dois meses, a interrupção do tratamento com tetrabenazina induziu piora nas crises de migrânea. Apresentamos este relato como sendo a primeira descrição na literatura mostrando efeitos benéficos da tetrabenazina, um bloqueador dos receptores dopaminérgicos, sobre o comportamento da migrânea com aura.PALAVRAS CHAVES: dopamina, enxaqueca, profilaxia, tetrabenazina.Change in the biologic pattern of the migraine with aura after the use of tetrabenazine: case report ABSTRACT -The influence of the dopaminergic system on the pathophysiology of migraine has been suggested as a result of recent genetic discoveries. A possible hyper-reactivity of the dopaminergic receptors DRD2 reinforced the evidence regarding this. We describe a 31 years-old male patient affected by a generalized dystonia secondary to perinatal hypoxia. At age 16, the patient started having headache crises that met the criteria for migraine with aura. After three years of treatment for dystonia with tetrabenazine, a clear reduction in the frequency, intensity and duration of the crises was perceived. During two periods longer than two months, the interruption of the treatment with tetrabenazine brought about an aggravation of the migraine crises. We present this case as being the first description in the literature showing the beneficial effects of tetrabenazine, a blocker of dopaminergic receptors, on the behavior of migraine with aura.KEY WORDS: dopamine, migraine, prophylaxis, tetrabenazine. Na migrânea sintomas como náuseas, vômitos e oscilações pressóricas podem ser atribuídos a ativação do sistema dopaminérgico. Em pacientes migranosos tem sido demonstrada hipersensibilidade aos agonistas dopaminérgicos e dos receptores monoaminérgicos 1 . Estudos genéticos em pacientes migranosos mostraram aumento na frequência dos alelos 1, responsáveis

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Apomorphine potentiates vagal bradycardia

Cited by 9 publications

References 7 publications

Effects of quinpirole on autonomic nervous control of heart rate in rats

Effects of quinpirole on autonomic nervous control of heart rate in rats

Dopamine Hypersensitivity in Migraine: Role in Apomorphine Syncope

Mudança no padrão biológico da migrânea com aura após a utilização da tetrabenazina: relato de caso

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